Tags

Type your tag names separated by a space and hit enter

Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review.
Nutrients 2018; 10(10)N

Abstract

Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A).

Authors+Show Affiliations

Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA. jacob.fulton@chatham.edu.FAME Laboratory, Department of Exercise Science, University of Thessaly, GR42100 Trikala, Greece. petros.cd@gmail.com.Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA. ACarrillo@chatham.edu. FAME Laboratory, Department of Exercise Science, University of Thessaly, GR42100 Trikala, Greece. ACarrillo@chatham.edu.Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA. J.Edsall@chatham.edu.Department of Exercise Physiology, West Virginia University School of Medicine, West Virginia University, Morganton, WV 26506, USA. ejfickes@hsc.wvu.edu.Department of Movement Science, Chatham University, Pittsburgh, PA 15232, USA. ERyan@chatham.edu.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

30257492

Citation

Fulton, Jacob L., et al. "Impact of Genetic Variability On Physiological Responses to Caffeine in Humans: a Systematic Review." Nutrients, vol. 10, no. 10, 2018.
Fulton JL, Dinas PC, Carrillo AE, et al. Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review. Nutrients. 2018;10(10).
Fulton, J. L., Dinas, P. C., Carrillo, A. E., Edsall, J. R., Ryan, E. J., & Ryan, E. J. (2018). Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review. Nutrients, 10(10), doi:10.3390/nu10101373.
Fulton JL, et al. Impact of Genetic Variability On Physiological Responses to Caffeine in Humans: a Systematic Review. Nutrients. 2018 Sep 25;10(10) PubMed PMID: 30257492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review. AU - Fulton,Jacob L, AU - Dinas,Petros C, AU - Carrillo,Andres E, AU - Edsall,Jason R, AU - Ryan,Emily J, AU - Ryan,Edward J, Y1 - 2018/09/25/ PY - 2018/09/01/received PY - 2018/09/21/revised PY - 2018/09/23/accepted PY - 2018/9/28/entrez PY - 2018/9/28/pubmed PY - 2019/1/18/medline KW - adenosine receptor KW - anxiety KW - caffeine KW - cytochrome P450 KW - ergogenic KW - pharmacogenomics KW - polymorphism JF - Nutrients JO - Nutrients VL - 10 IS - 10 N2 - Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A). SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30257492/Impact_of_Genetic_Variability_on_Physiological_Responses_to_Caffeine_in_Humans:_A_Systematic_Review_ L2 - http://www.mdpi.com/resolver?pii=nu10101373 DB - PRIME DP - Unbound Medicine ER -