Tags

Type your tag names separated by a space and hit enter

Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: A Multicenter Retrospective Case Series.
Neuromodulation. 2019 Jan; 22(1):96-100.N

Abstract

BACKGROUND

Peripheral neuropathy is a chronic pain disorder involving physical, chemical, or metabolic damage to peripheral nerves. Its pain can be intense and disabling. Dorsal root ganglion (DRG) stimulation is an effective treatment for neuropathic pain, including cases with the limited regional distributions that often characterize peripheral neuropathy.

METHODS

A retrospective analysis was completed. Patients were included on the basis of having chronic intractable peripheral neuropathy of the legs and/or feet and responding successfully to a trial of DRG stimulation with leads at L4-S1. Visual analog scale pain scores and pain medication usage were collected at the baseline visit and after six weeks of treatment. Eight consecutive patients across two study centers were included (7 male, 1 female; mean age: 64.8 ± 10.2 years). Six cases of neuropathy were bilateral and two were unilateral. One patient presented with chronic radiculopathy, two patients had neuropathy associated with diabetes, and five patients had neuropathy not associated with a diabetes history.

RESULTS

The pain was rated 7.38 ± 0.74 at baseline and decreased to 1.50 ± 1.31 at the 6-week follow-up, a reduction of 79.5 ± 18.8%. For individual patients, pain relief ranged from 42.86% to 100.00%; two patients experienced complete elimination of pain while seven of the eight patients experienced greater than 50% pain relief. In addition, three patients significantly decreased their pain medication use and four were able to discontinue their medications entirely.

CONCLUSION

This small multicenter retrospective case series provides preliminary evidence that the painful symptoms of general peripheral neuropathy in the lower extremities, as well as associated pain medication usage, can be effectively managed by DRG stimulation at the L4-S1 spinal level. Importantly, this treatment appears efficacious for peripheral neuropathy.

Authors+Show Affiliations

St. Luke's University Health Network, Bethlehem, PA, USA.Thrive Clinic LLC, Santa Rosa, CA, USA.Abbott Laboratories, Plano, TX, USA.

Pub Type(s)

Case Reports
Multicenter Study

Language

eng

PubMed ID

30264870

Citation

Falowski, Steven, et al. "Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: a Multicenter Retrospective Case Series." Neuromodulation : Journal of the International Neuromodulation Society, vol. 22, no. 1, 2019, pp. 96-100.
Falowski S, Pope JE, Raza A. Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: A Multicenter Retrospective Case Series. Neuromodulation. 2019;22(1):96-100.
Falowski, S., Pope, J. E., & Raza, A. (2019). Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: A Multicenter Retrospective Case Series. Neuromodulation : Journal of the International Neuromodulation Society, 22(1), 96-100. https://doi.org/10.1111/ner.12860
Falowski S, Pope JE, Raza A. Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: a Multicenter Retrospective Case Series. Neuromodulation. 2019;22(1):96-100. PubMed PMID: 30264870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early US Experience With Stimulation of the Dorsal Root Ganglia for the Treatment of Peripheral Neuropathy in the Lower Extremities: A Multicenter Retrospective Case Series. AU - Falowski,Steven, AU - Pope,Jason E, AU - Raza,Adil, Y1 - 2018/09/28/ PY - 2018/04/09/received PY - 2018/07/10/revised PY - 2018/08/15/accepted PY - 2018/9/29/pubmed PY - 2019/4/6/medline PY - 2018/9/29/entrez KW - Chronic pain KW - DRG stimulation KW - lower limb pain KW - neuromodulation KW - peripheral neuropathy SP - 96 EP - 100 JF - Neuromodulation : journal of the International Neuromodulation Society JO - Neuromodulation VL - 22 IS - 1 N2 - BACKGROUND: Peripheral neuropathy is a chronic pain disorder involving physical, chemical, or metabolic damage to peripheral nerves. Its pain can be intense and disabling. Dorsal root ganglion (DRG) stimulation is an effective treatment for neuropathic pain, including cases with the limited regional distributions that often characterize peripheral neuropathy. METHODS: A retrospective analysis was completed. Patients were included on the basis of having chronic intractable peripheral neuropathy of the legs and/or feet and responding successfully to a trial of DRG stimulation with leads at L4-S1. Visual analog scale pain scores and pain medication usage were collected at the baseline visit and after six weeks of treatment. Eight consecutive patients across two study centers were included (7 male, 1 female; mean age: 64.8 ± 10.2 years). Six cases of neuropathy were bilateral and two were unilateral. One patient presented with chronic radiculopathy, two patients had neuropathy associated with diabetes, and five patients had neuropathy not associated with a diabetes history. RESULTS: The pain was rated 7.38 ± 0.74 at baseline and decreased to 1.50 ± 1.31 at the 6-week follow-up, a reduction of 79.5 ± 18.8%. For individual patients, pain relief ranged from 42.86% to 100.00%; two patients experienced complete elimination of pain while seven of the eight patients experienced greater than 50% pain relief. In addition, three patients significantly decreased their pain medication use and four were able to discontinue their medications entirely. CONCLUSION: This small multicenter retrospective case series provides preliminary evidence that the painful symptoms of general peripheral neuropathy in the lower extremities, as well as associated pain medication usage, can be effectively managed by DRG stimulation at the L4-S1 spinal level. Importantly, this treatment appears efficacious for peripheral neuropathy. SN - 1525-1403 UR - https://www.unboundmedicine.com/medline/citation/30264870/Early_US_Experience_With_Stimulation_of_the_Dorsal_Root_Ganglia_for_the_Treatment_of_Peripheral_Neuropathy_in_the_Lower_Extremities:_A_Multicenter_Retrospective_Case_Series_ L2 - https://doi.org/10.1111/ner.12860 DB - PRIME DP - Unbound Medicine ER -