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Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets.
J Pharm Sci. 2019 02; 108(2):907-913.JP

Abstract

The production of three-dimensional (3D)-printed drugs holds promise for future personalized medicine. Here, we prepared tablets containing naftopidil as a model drug using a semisolid extrusion-type 3D bioprinter applicable for tissue engineering. A hydrogel is typically used as the printer ink for 3D bioprinters, and we incorporated various amounts of hydroxypropyl methylcellulose hydrogel (30%, 40%, and 50% gel) into the printer ink. The resulting 3D-printed gel product was dried to obtain tablets. The rheological properties of the printer ink changed as its composition was changed, and tablets were prepared successfully from several formulations. Increasing the amount of hydroxypropyl methylcellulose hydrogel in the printer ink led to delayed drug dissolution, decreased weight, and decreased hardness of the tablets. Delayed drug dissolution was also observed when the amount of disintegrating agent typically used in powder compression tablets was increased in the ink, and increasing the incorporated amount of the disintegrating agent crospovidone increased the hardness of the tablets. Our results will provide useful information for the preparation of tablets using semisolid extrusion-type 3D printers.

Authors+Show Affiliations

Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. Electronic address: ozekit@phar.nagoya-cu.ac.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30267782

Citation

Tagami, Tatsuaki, et al. "Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets." Journal of Pharmaceutical Sciences, vol. 108, no. 2, 2019, pp. 907-913.
Tagami T, Ando M, Nagata N, et al. Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets. J Pharm Sci. 2019;108(2):907-913.
Tagami, T., Ando, M., Nagata, N., Goto, E., Yoshimura, N., Takeuchi, T., Noda, T., & Ozeki, T. (2019). Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets. Journal of Pharmaceutical Sciences, 108(2), 907-913. https://doi.org/10.1016/j.xphs.2018.08.026
Tagami T, et al. Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets. J Pharm Sci. 2019;108(2):907-913. PubMed PMID: 30267782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication of Naftopidil-Loaded Tablets Using a Semisolid Extrusion-Type 3D Printer and the Characteristics of the Printed Hydrogel and Resulting Tablets. AU - Tagami,Tatsuaki, AU - Ando,Mutsumi, AU - Nagata,Noriko, AU - Goto,Eiichi, AU - Yoshimura,Natsumi, AU - Takeuchi,Takao, AU - Noda,Takehiro, AU - Ozeki,Tetsuya, Y1 - 2018/09/26/ PY - 2018/03/02/received PY - 2018/08/15/revised PY - 2018/08/23/accepted PY - 2018/9/30/pubmed PY - 2020/5/14/medline PY - 2018/9/30/entrez KW - excipient KW - hydrogel KW - physical characterization KW - rheology KW - tablet SP - 907 EP - 913 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 108 IS - 2 N2 - The production of three-dimensional (3D)-printed drugs holds promise for future personalized medicine. Here, we prepared tablets containing naftopidil as a model drug using a semisolid extrusion-type 3D bioprinter applicable for tissue engineering. A hydrogel is typically used as the printer ink for 3D bioprinters, and we incorporated various amounts of hydroxypropyl methylcellulose hydrogel (30%, 40%, and 50% gel) into the printer ink. The resulting 3D-printed gel product was dried to obtain tablets. The rheological properties of the printer ink changed as its composition was changed, and tablets were prepared successfully from several formulations. Increasing the amount of hydroxypropyl methylcellulose hydrogel in the printer ink led to delayed drug dissolution, decreased weight, and decreased hardness of the tablets. Delayed drug dissolution was also observed when the amount of disintegrating agent typically used in powder compression tablets was increased in the ink, and increasing the incorporated amount of the disintegrating agent crospovidone increased the hardness of the tablets. Our results will provide useful information for the preparation of tablets using semisolid extrusion-type 3D printers. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/30267782/Fabrication_of_Naftopidil_Loaded_Tablets_Using_a_Semisolid_Extrusion_Type_3D_Printer_and_the_Characteristics_of_the_Printed_Hydrogel_and_Resulting_Tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(18)30548-3 DB - PRIME DP - Unbound Medicine ER -