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Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment.
World J Pediatr 2018; 14(5):498-503WJ

Abstract

BACKGROUND

Limited data are available in relation to the clinical features of PIBO undergoing prolonged nebulization treatment with budesonide, terbutaline and ipratropium bromide. This retrospective study aimed to outline the features of clinical, high-resolution computed tomography (HRCT) and pulmonary function test (PFT) of PIBO, undergoing maintenance therapy utilizing a triple nebulization treatment and to determine the factors associated with prognosis.

METHODS

Children diagnosed with PIBO were followed up between April 2014 and March 2017. The clinical features after maintenance nebulization treatment for 12 months were thereafter summarized.

RESULTS

Thirty patients, 21 boys and 9 girls, were enrolled in the study. The median age of patients was 17.4 months, with a range between 3.0 and 33 months. Persistent coughing and wheezing were detected whilst wheezing and crackles were the common manifestations presented. HRCT scans revealed patchy ground and glass opacity, while PFT showed fixed airway obstruction in all patients. Four patients were lost during follow-up. After treatment, the clinical symptoms were improved greatly in all patients (P < 0.01). The mean increase in the percentage of TPEF%TE and VPEF%VE were improved greatly (P < 0.01). Images of the HRCT scan indicated marked improvements in 18 patients (81.8%) in comparison with scans obtained pre-treatment.

CONCLUSIONS

Our data suggest a potential role of long-term nebulization treatment of budesonide, terbutaline, ipratropium bromide on PIBO, due to its efficacy as indicated in the improved clinical symptoms, pulmonary functions and CT manifestations identified in the children. New prospective and controlled studies are required to confirm this proposition.

Authors+Show Affiliations

Respiratory Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China.Respiratory Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China.Radiology Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China.Respiratory Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China.Respiratory Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China.Respiratory Department, Children's Hospital of Fudan University, 399 Wan Yuan Rd, Shanghai, China. zhangxiaobo0307@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30269305

Citation

Zhang, Xiao-Mei, et al. "Clinical Features of Postinfectious Bronchiolitis Obliterans in Children Undergoing Long-term Nebulization Treatment." World Journal of Pediatrics : WJP, vol. 14, no. 5, 2018, pp. 498-503.
Zhang XM, Lu AZ, Yang HW, et al. Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment. World J Pediatr. 2018;14(5):498-503.
Zhang, X. M., Lu, A. Z., Yang, H. W., Qian, L. L., Wang, L. B., & Zhang, X. B. (2018). Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment. World Journal of Pediatrics : WJP, 14(5), pp. 498-503. doi:10.1007/s12519-018-0193-z.
Zhang XM, et al. Clinical Features of Postinfectious Bronchiolitis Obliterans in Children Undergoing Long-term Nebulization Treatment. World J Pediatr. 2018;14(5):498-503. PubMed PMID: 30269305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of postinfectious bronchiolitis obliterans in children undergoing long-term nebulization treatment. AU - Zhang,Xiao-Mei, AU - Lu,Ai-Zhen, AU - Yang,Hao-Wei, AU - Qian,Li-Ling, AU - Wang,Li-Bo, AU - Zhang,Xiao-Bo, Y1 - 2018/09/29/ PY - 2018/08/22/received PY - 2018/09/20/accepted PY - 2018/10/1/pubmed PY - 2019/2/15/medline PY - 2018/10/1/entrez KW - Clinical features KW - Nebulization treatment KW - Post-infectious bronchiolitis obliterans KW - Prognosis SP - 498 EP - 503 JF - World journal of pediatrics : WJP JO - World J Pediatr VL - 14 IS - 5 N2 - BACKGROUND: Limited data are available in relation to the clinical features of PIBO undergoing prolonged nebulization treatment with budesonide, terbutaline and ipratropium bromide. This retrospective study aimed to outline the features of clinical, high-resolution computed tomography (HRCT) and pulmonary function test (PFT) of PIBO, undergoing maintenance therapy utilizing a triple nebulization treatment and to determine the factors associated with prognosis. METHODS: Children diagnosed with PIBO were followed up between April 2014 and March 2017. The clinical features after maintenance nebulization treatment for 12 months were thereafter summarized. RESULTS: Thirty patients, 21 boys and 9 girls, were enrolled in the study. The median age of patients was 17.4 months, with a range between 3.0 and 33 months. Persistent coughing and wheezing were detected whilst wheezing and crackles were the common manifestations presented. HRCT scans revealed patchy ground and glass opacity, while PFT showed fixed airway obstruction in all patients. Four patients were lost during follow-up. After treatment, the clinical symptoms were improved greatly in all patients (P < 0.01). The mean increase in the percentage of TPEF%TE and VPEF%VE were improved greatly (P < 0.01). Images of the HRCT scan indicated marked improvements in 18 patients (81.8%) in comparison with scans obtained pre-treatment. CONCLUSIONS: Our data suggest a potential role of long-term nebulization treatment of budesonide, terbutaline, ipratropium bromide on PIBO, due to its efficacy as indicated in the improved clinical symptoms, pulmonary functions and CT manifestations identified in the children. New prospective and controlled studies are required to confirm this proposition. SN - 1867-0687 UR - https://www.unboundmedicine.com/medline/citation/30269305/Clinical_features_of_postinfectious_bronchiolitis_obliterans_in_children_undergoing_long_term_nebulization_treatment_ L2 - https://dx.doi.org/10.1007/s12519-018-0193-z DB - PRIME DP - Unbound Medicine ER -