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Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes.
Acta Sci Pol Technol Aliment. 2018 Jul-Sep; 17(3):219-226.AS

Abstract

BACKGROUND

A. ursinum is found to contain high levels of some beneficial phenolic and poly phenolic compounds were found to be effective in scavenging DPPH radicals and tyroinase inhibition. The aim of this study was to evaluate the anti-tyrosinase and antioxidant activity of three different extracts from the ultrasound-assisted method and their metal complexes from A. ursinum to discover new candidates for food additives, cosmetic and pharmaceutical products.

METHODS

Water, 70% ethanol and absolute ethanol extract of Allium ursinum and their man- ganese and zinc-complexes were characterized by FT-IR and UV-Vis spectra and their antioxidant and anti- tyrosinase activity determined using DPPH radical scavenging and mushroom tyrosinase assay.

RESULTS

The antioxidant activity of the water extract was superior to other samples, while the 70% ethanol extract exhibited the highest anti-tyrosinase activity. Metal complex formation of the extracts led to a signifi- cantly lower antioxidant effect. The tyrosinase inhibition strongly related to the metal ion and extraction sol- vent. All the zinc complexes had lower anti-tyrosinase activity than their extracts, while the manganese com- plex of the water and absolute ethanol extracts exhibited higher anti-tyrosinase activity than related extracts.

CONCLUSIONS

This study shows that Mn complex of A. ursinum extracts, based on the solvent extraction, could increase tyrosinase inhibition activity and could be a good candidate for intended cosmetic applications and food additives.

Authors+Show Affiliations

Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS) Tehran, Iran.Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS) Tehran, Iran.Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Iran.Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Iran.Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30269461

Citation

Nikkhahi, Mohammad, et al. "Evaluation of Anti-tyrosinase Activity of Allium Ursinum Extracts and Their Metal Complexes." Acta Scientiarum Polonorum. Technologia Alimentaria, vol. 17, no. 3, 2018, pp. 219-226.
Nikkhahi M, Souri E, Sarkhail P, et al. Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes. Acta Sci Pol Technol Aliment. 2018;17(3):219-226.
Nikkhahi, M., Souri, E., Sarkhail, P., Baeeri, M., & Mohammadhosseini, N. (2018). Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes. Acta Scientiarum Polonorum. Technologia Alimentaria, 17(3), 219-226. https://doi.org/10.17306/J.AFS.0585
Nikkhahi M, et al. Evaluation of Anti-tyrosinase Activity of Allium Ursinum Extracts and Their Metal Complexes. Acta Sci Pol Technol Aliment. 2018 Jul-Sep;17(3):219-226. PubMed PMID: 30269461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes. AU - Nikkhahi,Mohammad, AU - Souri,Effat, AU - Sarkhail,Parisa, AU - Baeeri,Maryam, AU - Mohammadhosseini,Negar, PY - 2018/10/2/entrez PY - 2018/10/3/pubmed PY - 2019/1/10/medline KW - Allium ursinum KW - anti-tyrosinase KW - antioxidant KW - metal complex KW - phenolic compounds SP - 219 EP - 226 JF - Acta scientiarum polonorum. Technologia alimentaria JO - Acta Sci Pol Technol Aliment VL - 17 IS - 3 N2 - BACKGROUND: A. ursinum is found to contain high levels of some beneficial phenolic and poly phenolic compounds were found to be effective in scavenging DPPH radicals and tyroinase inhibition. The aim of this study was to evaluate the anti-tyrosinase and antioxidant activity of three different extracts from the ultrasound-assisted method and their metal complexes from A. ursinum to discover new candidates for food additives, cosmetic and pharmaceutical products. METHODS: Water, 70% ethanol and absolute ethanol extract of Allium ursinum and their man- ganese and zinc-complexes were characterized by FT-IR and UV-Vis spectra and their antioxidant and anti- tyrosinase activity determined using DPPH radical scavenging and mushroom tyrosinase assay. RESULTS: The antioxidant activity of the water extract was superior to other samples, while the 70% ethanol extract exhibited the highest anti-tyrosinase activity. Metal complex formation of the extracts led to a signifi- cantly lower antioxidant effect. The tyrosinase inhibition strongly related to the metal ion and extraction sol- vent. All the zinc complexes had lower anti-tyrosinase activity than their extracts, while the manganese com- plex of the water and absolute ethanol extracts exhibited higher anti-tyrosinase activity than related extracts. CONCLUSIONS: This study shows that Mn complex of A. ursinum extracts, based on the solvent extraction, could increase tyrosinase inhibition activity and could be a good candidate for intended cosmetic applications and food additives. SN - 1898-9594 UR - https://www.unboundmedicine.com/medline/citation/30269461/Evaluation_of_anti_tyrosinase_activity_of_Allium_ursinum_extracts_and_their_metal_complexes_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -