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Cut-off points for height, weight and body mass index adjusted bioimpedance analysis measurements of muscle mass with use of different threshold definitions.
Aging Male. 2018 Sep 29 [Online ahead of print]AM

Abstract

AIM

Low muscle mass (LMM) is a prerequisite to define sarcopenia. We aimed to report muscle-mass reference cut-off points adjusted for height and weight as muscle-mass threshold best discriminating muscle-weakness and adjusted for body mass index (BMI) significantly lower than that of healthy young population.

MATERIAL AND METHOD

We included young adults between 18 and 39 years and community dwelling older adults 60-99 years of age. Bioimpedance analysis (BIA) was used to assess skeletal muscle mass. Skeletal muscle mass index (SMMI) adjusted for height, weight, BMI were calculated [SMMI (height), SMMI (weight), SMMI (BMI)]. Handgrip strength was evaluated with Jamar hydraulic dynamometer for muscle-strength. SMMI (height) and SMMI (weight) cut-offs that predict low muscle-strength were calculated with receiver operator characteristic (ROC) analysis. Low muscle-strength was evaluated by three different thresholds, i.e. 32 kg/22 kg, 30 kg/20 kg, 26 kg/16 kg in males/females. SMMI (BMI) cut-offs were calculated as "mean young SMMI (BMI)-two standard deviation."

RESULTS

The young and older reference groups included 301 and 992 individuals, respectively. LMM cut-points for SMMI (height) were (i) 10.8 vs. 8.9 kg/m2 for 32/22 kg; 10.8 vs. 9.4 kg/m2 for 30/20 kg and 11.1 vs. 8.9 kg/m2 for the 26/16 kg thresholds, in males and females, respectively. LMM cut-points for the SMMI (weight) were 40.6% and 33.2% for the all three studied muscle-strength thresholds for males and females, respectively. For all the analyses sensitivity, specificity and likelihood ratios were not sufficiently high in both genders. The SMMI (BMI) cut-points were 1.049 vs. 0.823 kg/BMI for males and females, respectively.

CONCLUSIONS

We presented the very first cut-off thresholds for muscle-mass adjusted by height and weight that best discriminate muscle-weakness in the older adults and by BMI that is significantly lower than that of healthy young population. This study suggests that correlation between total skeletal muscle mass measured by BIA (either adjusted for height or weight) and muscle strength is low.

Authors+Show Affiliations

a Department of Internal Medicine, Division of Geriatrics , Istanbul Medical School, Istanbul University, Capa , Istanbul , Turkey.b Department of Internal Medicine, Division of Geriatrics , Marmara University Hospital , Pendik, Istanbul , Turkey.a Department of Internal Medicine, Division of Geriatrics , Istanbul Medical School, Istanbul University, Capa , Istanbul , Turkey.c Istanbul Physical Medicine and Rehabilitation Training Hospital , Istanbul , Turkey.d Department of Internal Medicine , Istanbul Medical School, Istanbul University , Capa , Istanbul , Turkey.d Department of Internal Medicine , Istanbul Medical School, Istanbul University , Capa , Istanbul , Turkey.d Department of Internal Medicine , Istanbul Medical School, Istanbul University , Capa , Istanbul , Turkey.a Department of Internal Medicine, Division of Geriatrics , Istanbul Medical School, Istanbul University, Capa , Istanbul , Turkey.e Servicio de Geriatría, Hospital Universitario Ramón y Cajal , Madrid , Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30269625

Citation

Bahat, Gulistan, et al. "Cut-off Points for Height, Weight and Body Mass Index Adjusted Bioimpedance Analysis Measurements of Muscle Mass With Use of Different Threshold Definitions." The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 2018, pp. 1-6.
Bahat G, Tufan A, Kilic C, et al. Cut-off points for height, weight and body mass index adjusted bioimpedance analysis measurements of muscle mass with use of different threshold definitions. Aging Male. 2018.
Bahat, G., Tufan, A., Kilic, C., Aydın, T., Akpinar, T. S., Kose, M., Erten, N., Karan, M. A., & Cruz-Jentoft, A. J. (2018). Cut-off points for height, weight and body mass index adjusted bioimpedance analysis measurements of muscle mass with use of different threshold definitions. The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 1-6. https://doi.org/10.1080/13685538.2018.1499081
Bahat G, et al. Cut-off Points for Height, Weight and Body Mass Index Adjusted Bioimpedance Analysis Measurements of Muscle Mass With Use of Different Threshold Definitions. Aging Male. 2018 Sep 29;1-6. PubMed PMID: 30269625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cut-off points for height, weight and body mass index adjusted bioimpedance analysis measurements of muscle mass with use of different threshold definitions. AU - Bahat,Gulistan, AU - Tufan,Asli, AU - Kilic,Cihan, AU - Aydın,Tugba, AU - Akpinar,Timur Selçuk, AU - Kose,Murat, AU - Erten,Nilgun, AU - Karan,Mehmet Akif, AU - Cruz-Jentoft,Alfonso J, Y1 - 2018/09/29/ PY - 2018/10/2/entrez PY - 2018/10/3/pubmed PY - 2018/10/3/medline KW - Body mass index KW - sarcopenia KW - skeletal muscle mass index SP - 1 EP - 6 JF - The aging male : the official journal of the International Society for the Study of the Aging Male JO - Aging Male N2 - AIM: Low muscle mass (LMM) is a prerequisite to define sarcopenia. We aimed to report muscle-mass reference cut-off points adjusted for height and weight as muscle-mass threshold best discriminating muscle-weakness and adjusted for body mass index (BMI) significantly lower than that of healthy young population. MATERIAL AND METHOD: We included young adults between 18 and 39 years and community dwelling older adults 60-99 years of age. Bioimpedance analysis (BIA) was used to assess skeletal muscle mass. Skeletal muscle mass index (SMMI) adjusted for height, weight, BMI were calculated [SMMI (height), SMMI (weight), SMMI (BMI)]. Handgrip strength was evaluated with Jamar hydraulic dynamometer for muscle-strength. SMMI (height) and SMMI (weight) cut-offs that predict low muscle-strength were calculated with receiver operator characteristic (ROC) analysis. Low muscle-strength was evaluated by three different thresholds, i.e. 32 kg/22 kg, 30 kg/20 kg, 26 kg/16 kg in males/females. SMMI (BMI) cut-offs were calculated as "mean young SMMI (BMI)-two standard deviation." RESULTS: The young and older reference groups included 301 and 992 individuals, respectively. LMM cut-points for SMMI (height) were (i) 10.8 vs. 8.9 kg/m2 for 32/22 kg; 10.8 vs. 9.4 kg/m2 for 30/20 kg and 11.1 vs. 8.9 kg/m2 for the 26/16 kg thresholds, in males and females, respectively. LMM cut-points for the SMMI (weight) were 40.6% and 33.2% for the all three studied muscle-strength thresholds for males and females, respectively. For all the analyses sensitivity, specificity and likelihood ratios were not sufficiently high in both genders. The SMMI (BMI) cut-points were 1.049 vs. 0.823 kg/BMI for males and females, respectively. CONCLUSIONS: We presented the very first cut-off thresholds for muscle-mass adjusted by height and weight that best discriminate muscle-weakness in the older adults and by BMI that is significantly lower than that of healthy young population. This study suggests that correlation between total skeletal muscle mass measured by BIA (either adjusted for height or weight) and muscle strength is low. SN - 1473-0790 UR - https://www.unboundmedicine.com/medline/citation/30269625/Cut_off_points_for_height_weight_and_body_mass_index_adjusted_bioimpedance_analysis_measurements_of_muscle_mass_with_use_of_different_threshold_definitions_ L2 - http://www.tandfonline.com/doi/full/10.1080/13685538.2018.1499081 DB - PRIME DP - Unbound Medicine ER -
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