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Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease.
Circ J. 2018 11 24; 82(12):3069-3075.CJ

Abstract

BACKGROUND

The prognosis of peripheral artery disease (PAD) and comorbid sarcopenia is poor. Some reports indicate that the computed tomography (CT) value of skeletal muscle, which reflects intramuscular fat deposition as well as skeletal muscle mass, is considered a marker of sarcopenia. However, it remains unclear if skeletal muscle area and CT value are associated with poor outcomes in patients with PAD. Methods and Results: Psoas muscle area and CT value were measured by manual trace at the level of the third lumbar vertebral body in 327 consecutive patients with PAD undergoing endovascular therapy (EVT). The endpoint was major adverse cardiovascular and limb events (MACLE). There were 60 MACLE during the follow-up period. Patients with MACLE had lower mean psoas muscle CT value than those without. However, there was no significant difference in total psoas muscle area between patients with and without MACLE. Kaplan-Meier analysis demonstrated that the lowest tertile of psoas muscle CT value was associated with the highest risk of MACLE. Multivariate Cox hazard analysis revealed that psoas muscle CT value was associated with MACLE after adjustment for Fontaine class, previous ischemic heart disease, prevalence of diabetes mellitus, brain natriuretic peptide, and serum albumin.

CONCLUSIONS

Psoas muscle CT value is a feasible predictor of MACLE in patients with PAD.

Authors+Show Affiliations

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

30270315

Citation

Sugai, Takayuki, et al. "Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease." Circulation Journal : Official Journal of the Japanese Circulation Society, vol. 82, no. 12, 2018, pp. 3069-3075.
Sugai T, Watanabe T, Otaki Y, et al. Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease. Circ J. 2018;82(12):3069-3075.
Sugai, T., Watanabe, T., Otaki, Y., Goto, J., Watanabe, K., Toshima, T., Takahashi, T., Yokoyama, M., Tamura, H., Nishiyama, S., Arimoto, T., Takahashi, H., Shishido, T., & Watanabe, M. (2018). Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease. Circulation Journal : Official Journal of the Japanese Circulation Society, 82(12), 3069-3075. https://doi.org/10.1253/circj.CJ-18-0726
Sugai T, et al. Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease. Circ J. 2018 11 24;82(12):3069-3075. PubMed PMID: 30270315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased Psoas Muscle Computed Tomography Value Predicts Poor Outcome in Peripheral Artery Disease. AU - Sugai,Takayuki, AU - Watanabe,Tetsu, AU - Otaki,Yoichiro, AU - Goto,Jun, AU - Watanabe,Ken, AU - Toshima,Taku, AU - Takahashi,Tetsuya, AU - Yokoyama,Miyuki, AU - Tamura,Harutoshi, AU - Nishiyama,Satoshi, AU - Arimoto,Takanori, AU - Takahashi,Hiroki, AU - Shishido,Tetsuro, AU - Watanabe,Masafumi, Y1 - 2018/09/29/ PY - 2018/10/3/pubmed PY - 2019/11/13/medline PY - 2018/10/2/entrez KW - Computed tomography KW - Intramuscular fat deposition KW - Peripheral artery disease KW - Psoas muscle KW - Sarcopenia SP - 3069 EP - 3075 JF - Circulation journal : official journal of the Japanese Circulation Society JO - Circ J VL - 82 IS - 12 N2 - BACKGROUND: The prognosis of peripheral artery disease (PAD) and comorbid sarcopenia is poor. Some reports indicate that the computed tomography (CT) value of skeletal muscle, which reflects intramuscular fat deposition as well as skeletal muscle mass, is considered a marker of sarcopenia. However, it remains unclear if skeletal muscle area and CT value are associated with poor outcomes in patients with PAD. Methods and Results: Psoas muscle area and CT value were measured by manual trace at the level of the third lumbar vertebral body in 327 consecutive patients with PAD undergoing endovascular therapy (EVT). The endpoint was major adverse cardiovascular and limb events (MACLE). There were 60 MACLE during the follow-up period. Patients with MACLE had lower mean psoas muscle CT value than those without. However, there was no significant difference in total psoas muscle area between patients with and without MACLE. Kaplan-Meier analysis demonstrated that the lowest tertile of psoas muscle CT value was associated with the highest risk of MACLE. Multivariate Cox hazard analysis revealed that psoas muscle CT value was associated with MACLE after adjustment for Fontaine class, previous ischemic heart disease, prevalence of diabetes mellitus, brain natriuretic peptide, and serum albumin. CONCLUSIONS: Psoas muscle CT value is a feasible predictor of MACLE in patients with PAD. SN - 1347-4820 UR - https://www.unboundmedicine.com/medline/citation/30270315/Decreased_Psoas_Muscle_Computed_Tomography_Value_Predicts_Poor_Outcome_in_Peripheral_Artery_Disease_ L2 - https://dx.doi.org/10.1253/circj.CJ-18-0726 DB - PRIME DP - Unbound Medicine ER -