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The association between COPD and outcomes of patients with advanced chronic kidney disease.
Int J Chron Obstruct Pulmon Dis 2018; 13:2899-2905IJ

Abstract

Objective

The aim of this study was to investigate the impact of COPD on the outcomes of patients with advanced chronic kidney disease (CKD).

Patients and methods

All patients with advanced CKD from 2000 to 2010 were identified from the Taiwanese National Health Insurance Research Database. Associations between COPD and the risk of long-term dialysis and all-cause mortality were assessed.

Results

A total of 33,399 advanced CKD patients were enrolled, of whom 31,536 did not have COPD (non-COPD group) and 1,863 had COPD (COPD group). The incidence of end-stage renal disease (ESRD) was higher for those with COPD than those without COPD (744.2 per 1,000 person-years vs 724.6 per 1,000 person-years, adjusted HR [aHR] 1.04; 95% CI 0.96-1.12). The cumulative incidence rates of ESRD were similar between the COPD and non-COPD groups (log-rank test, P=0.356). Overall, the patients with COPD had a higher risk of death than those without COPD (151.7 per 1,000 person-years vs 125.5 per 1,000 person-years, aHR 1.22; 95% CI 1.11-1.33). The cumulative mortality rate was higher in the COPD group than in the non-COPD group (log-rank test, P<0.001).

Conclusion

COPD increased the risk of mortality among the advanced CKD patients in this study, especially the elderly and male patients. In contrast, COPD did not increase the risk of ESRD among the advanced CKD patients.

Authors+Show Affiliations

Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan.Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan. School of Medicine, Tzu Chi University, Hualien, Zhunan, Taiwan.Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, yhwang531@gmail.com; cywang@mospital.com.Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, yhwang531@gmail.com; cywang@mospital.com.Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

30271136

Citation

Lai, Chih-Cheng, et al. "The Association Between COPD and Outcomes of Patients With Advanced Chronic Kidney Disease." International Journal of Chronic Obstructive Pulmonary Disease, vol. 13, 2018, pp. 2899-2905.
Lai CC, Wu CH, Wang YH, et al. The association between COPD and outcomes of patients with advanced chronic kidney disease. Int J Chron Obstruct Pulmon Dis. 2018;13:2899-2905.
Lai, C. C., Wu, C. H., Wang, Y. H., Wang, C. Y., Wu, V. C., & Chen, L. (2018). The association between COPD and outcomes of patients with advanced chronic kidney disease. International Journal of Chronic Obstructive Pulmonary Disease, 13, pp. 2899-2905. doi:10.2147/COPD.S174215.
Lai CC, et al. The Association Between COPD and Outcomes of Patients With Advanced Chronic Kidney Disease. Int J Chron Obstruct Pulmon Dis. 2018;13:2899-2905. PubMed PMID: 30271136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between COPD and outcomes of patients with advanced chronic kidney disease. AU - Lai,Chih-Cheng, AU - Wu,Che-Hsiung, AU - Wang,Ya-Hui, AU - Wang,Cheng-Yi, AU - Wu,Vin-Cent, AU - Chen,Likwang, Y1 - 2018/09/17/ PY - 2018/10/2/entrez PY - 2018/10/3/pubmed PY - 2019/3/9/medline KW - CKD KW - COPD KW - ESRD KW - mortality SP - 2899 EP - 2905 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 13 N2 - Objective: The aim of this study was to investigate the impact of COPD on the outcomes of patients with advanced chronic kidney disease (CKD). Patients and methods: All patients with advanced CKD from 2000 to 2010 were identified from the Taiwanese National Health Insurance Research Database. Associations between COPD and the risk of long-term dialysis and all-cause mortality were assessed. Results: A total of 33,399 advanced CKD patients were enrolled, of whom 31,536 did not have COPD (non-COPD group) and 1,863 had COPD (COPD group). The incidence of end-stage renal disease (ESRD) was higher for those with COPD than those without COPD (744.2 per 1,000 person-years vs 724.6 per 1,000 person-years, adjusted HR [aHR] 1.04; 95% CI 0.96-1.12). The cumulative incidence rates of ESRD were similar between the COPD and non-COPD groups (log-rank test, P=0.356). Overall, the patients with COPD had a higher risk of death than those without COPD (151.7 per 1,000 person-years vs 125.5 per 1,000 person-years, aHR 1.22; 95% CI 1.11-1.33). The cumulative mortality rate was higher in the COPD group than in the non-COPD group (log-rank test, P<0.001). Conclusion: COPD increased the risk of mortality among the advanced CKD patients in this study, especially the elderly and male patients. In contrast, COPD did not increase the risk of ESRD among the advanced CKD patients. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/30271136/The_association_between_COPD_and_outcomes_of_patients_with_advanced_chronic_kidney_disease_ L2 - https://dx.doi.org/10.2147/COPD.S174215 DB - PRIME DP - Unbound Medicine ER -