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Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis.
Biomed Res Int. 2018; 2018:8251097.BR

Abstract

Aim of the Study

The aim of the study was to conduct an ultrasound (US) assessment of changes in fingernails in psoriatic patients with nail involvement.

Material

A total of 69 patients with psoriatic changes in nails participated in the study, including 38 patients with psoriasis (Ps) and 31 with psoriatic arthritis (PsA) and 30 people in the control group. A total of 988 nails were examined.

Results

The thickness of the nail plate, nail bed, and matrix as shown in an ultrasound examination increased with the mNAPSI index (r=0.328, p=0.021; r=0.219, p=0.036; and r=0.422, p=0.011, respectively). The thickness of nail plate, bed, and matrix in patients with onycholysis and hyperkeratosis-type changes (concomitant or present separately) was significantly greater than when only pitting-type changes occurred (p=0.007, p=0.035, and p=0.023, respectively). An examination of nails with only pitting-type changes showed an increase in the matrix thickness compared to the control group (p=0.018). The focal hyperechoic involvement of the dorsal plate (80%) was the change most often observed in an US examination in Ps patients, whereas loosening of the borders of the ventral plate was most often observed in PsA patients. The thickness of nail bed in PsA patients increased with the duration of arthritis (r=0.399, p=0.022) and was correlated with the number of swollen digits (r=0.278, p=0.041).

Conclusions

The findings of this study may indicate an association of an inflammation in the nail bed with PsA development. Apart from a direct assessment of the described morphological changes of nails, a US examination could prove useful in an assessment of intensity of a local inflammation as a prognostic factor for PsA development.

Authors+Show Affiliations

Department of Rheumatology, Municipal Hospital in Olsztyn, 10-900 Olsztyn, Poland. Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland. Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.Faculty of Earth Sciences, Department of Geomatics and Cartography Nicolaus Copernicus University, Torun, Poland. DRAMIŃSKI S.A. Ultrasound Scanners, Olsztyn, Poland.DRAMIŃSKI S.A. Ultrasound Scanners, Olsztyn, Poland.Department of Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland. Laboratory for Regenerative Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-900 Olsztyn, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30271786

Citation

Krajewska-Włodarczyk, Magdalena, et al. "Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis." BioMed Research International, vol. 2018, 2018, p. 8251097.
Krajewska-Włodarczyk M, Owczarczyk-Saczonek A, Placek W, et al. Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis. Biomed Res Int. 2018;2018:8251097.
Krajewska-Włodarczyk, M., Owczarczyk-Saczonek, A., Placek, W., Wojtkiewicz, M., Wiktorowicz, A., & Wojtkiewicz, J. (2018). Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis. BioMed Research International, 2018, 8251097. https://doi.org/10.1155/2018/8251097
Krajewska-Włodarczyk M, et al. Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis. Biomed Res Int. 2018;2018:8251097. PubMed PMID: 30271786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrasound Assessment of Changes in Nails in Psoriasis and Psoriatic Arthritis. AU - Krajewska-Włodarczyk,Magdalena, AU - Owczarczyk-Saczonek,Agnieszka, AU - Placek,Waldemar, AU - Wojtkiewicz,Maja, AU - Wiktorowicz,Andrzej, AU - Wojtkiewicz,Joanna, Y1 - 2018/09/09/ PY - 2018/05/20/received PY - 2018/08/16/accepted PY - 2018/10/2/entrez PY - 2018/10/3/pubmed PY - 2019/1/8/medline SP - 8251097 EP - 8251097 JF - BioMed research international JO - Biomed Res Int VL - 2018 N2 - Aim of the Study: The aim of the study was to conduct an ultrasound (US) assessment of changes in fingernails in psoriatic patients with nail involvement. Material: A total of 69 patients with psoriatic changes in nails participated in the study, including 38 patients with psoriasis (Ps) and 31 with psoriatic arthritis (PsA) and 30 people in the control group. A total of 988 nails were examined. Results: The thickness of the nail plate, nail bed, and matrix as shown in an ultrasound examination increased with the mNAPSI index (r=0.328, p=0.021; r=0.219, p=0.036; and r=0.422, p=0.011, respectively). The thickness of nail plate, bed, and matrix in patients with onycholysis and hyperkeratosis-type changes (concomitant or present separately) was significantly greater than when only pitting-type changes occurred (p=0.007, p=0.035, and p=0.023, respectively). An examination of nails with only pitting-type changes showed an increase in the matrix thickness compared to the control group (p=0.018). The focal hyperechoic involvement of the dorsal plate (80%) was the change most often observed in an US examination in Ps patients, whereas loosening of the borders of the ventral plate was most often observed in PsA patients. The thickness of nail bed in PsA patients increased with the duration of arthritis (r=0.399, p=0.022) and was correlated with the number of swollen digits (r=0.278, p=0.041). Conclusions: The findings of this study may indicate an association of an inflammation in the nail bed with PsA development. Apart from a direct assessment of the described morphological changes of nails, a US examination could prove useful in an assessment of intensity of a local inflammation as a prognostic factor for PsA development. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/30271786/Ultrasound_Assessment_of_Changes_in_Nails_in_Psoriasis_and_Psoriatic_Arthritis_ L2 - https://dx.doi.org/10.1155/2018/8251097 DB - PRIME DP - Unbound Medicine ER -