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Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial.
J Nutr Health Aging. 2018; 22(8):944-951.JN

Abstract

BACKGROUND

Cognitive frailty is defined as the presence of both physical frailty and cognitive impairment (clinical dementia rating score = 0.5), in the absence of dementia. It is characterized by concurrent physical frailty and potentially reversible cognitive impairment. In this study, we sought to elucidate the effects of high-speed resistance exercise training on cognitive function and physical performance in older adults with cognitive frailty.

METHODS

We conducted a parallel-group, randomized controlled trial involving community-living older adults with cognitive frailty. The participants' mean age was 73.9 (± 4.3 SD) years, and 69.8% (n=30) were female. Two different 4-month interventions included high-speed resistance exercise training group (n=22) and a control group (balance and band stretching, n=23). Frailty score, cognitive function (memory, processing speed, cognitive flexibility, working memory, executive function), physical function (SPPB, TUG, gait speed), and muscle strength (grip strength, knee extension strength) were assessed at baseline, 8 weeks, and 16 weeks.

RESULTS

Statistical analysis showed that exercise improved performance significantly in the tests for cognitive function (processing speed and executive function, both p < 0.05), physical function (SPPB, TUG, gait speed, both p < 0.05), and muscle strength (grip strength, knee extension strength, both p < 0.05). However, no significant changes in frailty score were observed between intervention and either control group (p < 0.05).

CONCLUSION

In conclusion, our findings indicate that high-speed resistance exercise training approaches are effective in improving cognitive function and physical performance in older adults with cognitive frailty. This study shows that it is feasible to identify older adults with cognitive frailty in the community and primary care setting for effective intervention to reduce their level of frailty and cognitive impairment.

Authors+Show Affiliations

Jun-Young Lee, M.D., Ph.D, Associate Professor, Department of Psychiatry and Neuroscience Research Institute, Seoul National University College of Medicine. SMG-SNU Boramae Medical Center, 5-20, Boramae-Ro, Dongjak-gu, Seoul 07061, Korea, E-mail: benji@snu.ac.kr, Phone: 82-2-870-2462.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30272098

Citation

Yoon, D H., et al. "Effects of Resistance Exercise Training On Cognitive Function and Physical Performance in Cognitive Frailty: a Randomized Controlled Trial." The Journal of Nutrition, Health & Aging, vol. 22, no. 8, 2018, pp. 944-951.
Yoon DH, Lee JY, Song W. Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial. J Nutr Health Aging. 2018;22(8):944-951.
Yoon, D. H., Lee, J. Y., & Song, W. (2018). Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial. The Journal of Nutrition, Health & Aging, 22(8), 944-951. https://doi.org/10.1007/s12603-018-1090-9
Yoon DH, Lee JY, Song W. Effects of Resistance Exercise Training On Cognitive Function and Physical Performance in Cognitive Frailty: a Randomized Controlled Trial. J Nutr Health Aging. 2018;22(8):944-951. PubMed PMID: 30272098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial. AU - Yoon,D H, AU - Lee,J-Y, AU - Song,W, PY - 2018/10/2/entrez PY - 2018/10/3/pubmed PY - 2019/10/9/medline KW - Cognitive frailty KW - mild cognitive impairment KW - physical frailty KW - randomized clinical trials KW - resistance training SP - 944 EP - 951 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 22 IS - 8 N2 - BACKGROUND: Cognitive frailty is defined as the presence of both physical frailty and cognitive impairment (clinical dementia rating score = 0.5), in the absence of dementia. It is characterized by concurrent physical frailty and potentially reversible cognitive impairment. In this study, we sought to elucidate the effects of high-speed resistance exercise training on cognitive function and physical performance in older adults with cognitive frailty. METHODS: We conducted a parallel-group, randomized controlled trial involving community-living older adults with cognitive frailty. The participants' mean age was 73.9 (± 4.3 SD) years, and 69.8% (n=30) were female. Two different 4-month interventions included high-speed resistance exercise training group (n=22) and a control group (balance and band stretching, n=23). Frailty score, cognitive function (memory, processing speed, cognitive flexibility, working memory, executive function), physical function (SPPB, TUG, gait speed), and muscle strength (grip strength, knee extension strength) were assessed at baseline, 8 weeks, and 16 weeks. RESULTS: Statistical analysis showed that exercise improved performance significantly in the tests for cognitive function (processing speed and executive function, both p < 0.05), physical function (SPPB, TUG, gait speed, both p < 0.05), and muscle strength (grip strength, knee extension strength, both p < 0.05). However, no significant changes in frailty score were observed between intervention and either control group (p < 0.05). CONCLUSION: In conclusion, our findings indicate that high-speed resistance exercise training approaches are effective in improving cognitive function and physical performance in older adults with cognitive frailty. This study shows that it is feasible to identify older adults with cognitive frailty in the community and primary care setting for effective intervention to reduce their level of frailty and cognitive impairment. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/30272098/Effects_of_Resistance_Exercise_Training_on_Cognitive_Function_and_Physical_Performance_in_Cognitive_Frailty:_A_Randomized_Controlled_Trial_ L2 - https://doi.org/10.1007/s12603-018-1090-9 DB - PRIME DP - Unbound Medicine ER -