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DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion.
Nutrients. 2018 Sep 28; 10(10)N

Abstract

Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal uric acid excretion. Furthermore, it inhibited the activity of xanthine oxidase (XOD) in vitro and in the liver in addition to reducing hepatic uric acid production. DKB114 decreased cellular uric acid uptake in oocytes and HEK293 cells expressing human urate transporter (hURAT)1 and decreased the protein expression levels of urate transporters, URAT1, and glucose transporter, GLUT9, associated with the reabsorption of uric acid in the kidney. DKB114 exerts antihyperuricemic effects and uricosuric effects, which are accompanied, partially, by a reduction in the production of uric acid and promotion of uric acid excretion via the inhibition of XOD activity and reabsorption of uric acid. Therefore, it may have potential as a treatment for hyperuricemia and gout.

Authors+Show Affiliations

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea. rheeys04@kiom.re.kr.Institute of Traditional Medicine and Bioscience, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Korea. sksh518@dju.kr.Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea. yukhj@kiom.re.kr.Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea. dskim@kiom.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30274153

Citation

Lee, Young-Sil, et al. "DKB114, a Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia Through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion." Nutrients, vol. 10, no. 10, 2018.
Lee YS, Kim SH, Yuk HJ, et al. DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. Nutrients. 2018;10(10).
Lee, Y. S., Kim, S. H., Yuk, H. J., & Kim, D. S. (2018). DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. Nutrients, 10(10). https://doi.org/10.3390/nu10101381
Lee YS, et al. DKB114, a Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia Through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. Nutrients. 2018 Sep 28;10(10) PubMed PMID: 30274153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. AU - Lee,Young-Sil, AU - Kim,Seung-Hyung, AU - Yuk,Heung Joo, AU - Kim,Dong-Seon, Y1 - 2018/09/28/ PY - 2018/08/30/received PY - 2018/09/18/revised PY - 2018/09/25/accepted PY - 2018/10/3/entrez PY - 2018/10/3/pubmed PY - 2019/1/3/medline KW - Chrysanthemum indicum Linne flower KW - Cinnamomum cassia (L.) J. Presl bark KW - hyperuricemia KW - urate transporters KW - xanthine oxidase JF - Nutrients JO - Nutrients VL - 10 IS - 10 N2 - Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal uric acid excretion. Furthermore, it inhibited the activity of xanthine oxidase (XOD) in vitro and in the liver in addition to reducing hepatic uric acid production. DKB114 decreased cellular uric acid uptake in oocytes and HEK293 cells expressing human urate transporter (hURAT)1 and decreased the protein expression levels of urate transporters, URAT1, and glucose transporter, GLUT9, associated with the reabsorption of uric acid in the kidney. DKB114 exerts antihyperuricemic effects and uricosuric effects, which are accompanied, partially, by a reduction in the production of uric acid and promotion of uric acid excretion via the inhibition of XOD activity and reabsorption of uric acid. Therefore, it may have potential as a treatment for hyperuricemia and gout. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30274153/DKB114_A_Mixture_of_Chrysanthemum_Indicum_Linne_Flower_and_Cinnamomum_Cassia__L___J__Presl_Bark_Extracts_Improves_Hyperuricemia_through_Inhibition_of_Xanthine_Oxidase_Activity_and_Increasing_Urine_Excretion_ L2 - http://www.mdpi.com/resolver?pii=nu10101381 DB - PRIME DP - Unbound Medicine ER -