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Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment.
Curr Top Med Chem. 2018; 18(15):1333-1348.CT

Abstract

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. They usually are geographically restricted and have natural habitats in soil or in plants, and when fungal propagules invade mammalian host by inhalation, they initiate an inflammatory reaction that can result in self-resolution of the infection or cause an acute or chronic disease. In the setting of the AIDS pandemic and the developments in modern medicine, such as immunosuppressive therapy in cancer surgery patients and in transplantation and autoimmune diseases, the incidence of endemic mycoses has progressively increased. Another important factor of the increased incidence of systemic mycoses in certain regions is the progressive devastation of tropical and subtropical forests. In this review, we focus on two of the most important systemic mycoses: paracoccidioidomycosis and histoplasmosis, and their major characteristics in epidemiology, clinical aspects and laboratorial diagnosis.

Authors+Show Affiliations

Institute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, SP, Brazil. Laboratory of Medical Mycology, Tropical Medicine Institute USP-LIM53/Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.Laboratory of Medical Mycology, Tropical Medicine Institute USP-LIM53/Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.Laboratory of Medical Mycology, Tropical Medicine Institute USP-LIM53/Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.Pathology Department, Medical School, University of Sao Paulo,Sao Paulo, SP, Brazil.Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30277157

Citation

Taborda, C P., et al. "Paracoccidioides Spp. and Histoplasma Capsulatum: Current and New Perspectives for Diagnosis and Treatment." Current Topics in Medicinal Chemistry, vol. 18, no. 15, 2018, pp. 1333-1348.
Taborda CP, Buccheri R, Benard G, et al. Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment. Curr Top Med Chem. 2018;18(15):1333-1348.
Taborda, C. P., Buccheri, R., Benard, G., Duarte-Neto, A. N., Nosanchuk, J. D., & Travassos, L. R. (2018). Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment. Current Topics in Medicinal Chemistry, 18(15), 1333-1348. https://doi.org/10.2174/1568026618666181002112231
Taborda CP, et al. Paracoccidioides Spp. and Histoplasma Capsulatum: Current and New Perspectives for Diagnosis and Treatment. Curr Top Med Chem. 2018;18(15):1333-1348. PubMed PMID: 30277157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment. AU - Taborda,C P, AU - Buccheri,R, AU - Benard,G, AU - Duarte-Neto,A N, AU - Nosanchuk,J D, AU - Travassos,L R, PY - 2018/07/04/received PY - 2018/08/09/revised PY - 2018/09/26/accepted PY - 2018/10/3/pubmed PY - 2019/2/23/medline PY - 2018/10/3/entrez KW - AIDs KW - Chronic disease KW - Histoplasmosis KW - Infection KW - Paracoccidioidomycosis KW - Penicillium. SP - 1333 EP - 1348 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 18 IS - 15 N2 - The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitides, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. They usually are geographically restricted and have natural habitats in soil or in plants, and when fungal propagules invade mammalian host by inhalation, they initiate an inflammatory reaction that can result in self-resolution of the infection or cause an acute or chronic disease. In the setting of the AIDS pandemic and the developments in modern medicine, such as immunosuppressive therapy in cancer surgery patients and in transplantation and autoimmune diseases, the incidence of endemic mycoses has progressively increased. Another important factor of the increased incidence of systemic mycoses in certain regions is the progressive devastation of tropical and subtropical forests. In this review, we focus on two of the most important systemic mycoses: paracoccidioidomycosis and histoplasmosis, and their major characteristics in epidemiology, clinical aspects and laboratorial diagnosis. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/30277157/Paracoccidioides_spp__and_Histoplasma_capsulatum:_Current_and_New_Perspectives_for_Diagnosis_and_Treatment_ L2 - http://www.eurekaselect.com/165829/article DB - PRIME DP - Unbound Medicine ER -