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Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: A population-based cohort study in Taiwan.

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among the women of reproductive age. We conducted a nationwide population-based retrospective cohort study to analyze the association between PCOS and the subsequent development of gynecological cancers, namely endometrial, breast, and ovarian cancer.For this population-based cohort study, we used the Taiwan National Health Insurance Research Database, which contains information on approximately 24.7 million insured individuals. The cohort included women who had received a diagnosis of PCOS between 1998 and 2013. An age-matched systematic random-sampling method with a ratio of 1:4 was used for patient selection for the non-PCOS reference cohort. Multivariate Cox proportional hazard regression analysis was used to determine the effects of PCOS on the risks of gynecologic and breast cancer. The data are presented as hazard ratios (HRs) with 95% confidence intervals (CIs).The PCOS cohort consisted of 8155 patients with PCOS, and the comparison cohort consisted of 32,620 matched patients without PCOS. The incidence of endometrial cancer was 226 and 15 per 100,000 person-years in the PCOS and comparison groups, respectively. A statistically significant higher risk of endometrial cancer was found in the PCOS cohort (adjusted HR [aHR] = 17.7, 95% CI = 4.9-64.2) than in the comparison cohort. However, no association was observed between PCOS and ovarian (aHR = 1.64, 95% CI: 0.63-4.27) or breast cancer (aHR = 0.98, 95% CI: 0.58-1.65).The results of this large population-based cohort study supported the premise that women with PCOS might have an increased risk of endometrial cancer, but no association between PCOS and the risks of ovarian and breast cancer was found.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University. Institute of Medical Sciences, Tzu Chi University, Hualien.

    ,

    Management Office for Health Data, China Medical University Hospital. College of Medicine, China Medical University, Taichung.

    ,

    Department of Research.

    Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, and Tzu Chi University, Hualien, Taiwan.

    Source

    Medicine 97:39 2018 Sep pg e12608

    MeSH

    Adolescent
    Adult
    Breast Neoplasms
    Comorbidity
    Endometrial Neoplasms
    Female
    Humans
    Incidence
    Middle Aged
    Ovarian Neoplasms
    Polycystic Ovary Syndrome
    Retrospective Studies
    Risk Factors
    Taiwan
    Young Adult

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    30278576

    Citation

    Ding, Dah-Ching, et al. "Association Between Polycystic Ovarian Syndrome and Endometrial, Ovarian, and Breast Cancer: a Population-based Cohort Study in Taiwan." Medicine, vol. 97, no. 39, 2018, pp. e12608.
    Ding DC, Chen W, Wang JH, et al. Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: A population-based cohort study in Taiwan. Medicine (Baltimore). 2018;97(39):e12608.
    Ding, D. C., Chen, W., Wang, J. H., & Lin, S. Z. (2018). Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: A population-based cohort study in Taiwan. Medicine, 97(39), pp. e12608. doi:10.1097/MD.0000000000012608.
    Ding DC, et al. Association Between Polycystic Ovarian Syndrome and Endometrial, Ovarian, and Breast Cancer: a Population-based Cohort Study in Taiwan. Medicine (Baltimore). 2018;97(39):e12608. PubMed PMID: 30278576.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between polycystic ovarian syndrome and endometrial, ovarian, and breast cancer: A population-based cohort study in Taiwan. AU - Ding,Dah-Ching, AU - Chen,Weishan, AU - Wang,Jen-Hung, AU - Lin,Shinn-Zong, PY - 2018/10/4/entrez PY - 2018/10/4/pubmed PY - 2018/10/12/medline SP - e12608 EP - e12608 JF - Medicine JO - Medicine (Baltimore) VL - 97 IS - 39 N2 - Polycystic ovary syndrome (PCOS) is a common endocrine disorder among the women of reproductive age. We conducted a nationwide population-based retrospective cohort study to analyze the association between PCOS and the subsequent development of gynecological cancers, namely endometrial, breast, and ovarian cancer.For this population-based cohort study, we used the Taiwan National Health Insurance Research Database, which contains information on approximately 24.7 million insured individuals. The cohort included women who had received a diagnosis of PCOS between 1998 and 2013. An age-matched systematic random-sampling method with a ratio of 1:4 was used for patient selection for the non-PCOS reference cohort. Multivariate Cox proportional hazard regression analysis was used to determine the effects of PCOS on the risks of gynecologic and breast cancer. The data are presented as hazard ratios (HRs) with 95% confidence intervals (CIs).The PCOS cohort consisted of 8155 patients with PCOS, and the comparison cohort consisted of 32,620 matched patients without PCOS. The incidence of endometrial cancer was 226 and 15 per 100,000 person-years in the PCOS and comparison groups, respectively. A statistically significant higher risk of endometrial cancer was found in the PCOS cohort (adjusted HR [aHR] = 17.7, 95% CI = 4.9-64.2) than in the comparison cohort. However, no association was observed between PCOS and ovarian (aHR = 1.64, 95% CI: 0.63-4.27) or breast cancer (aHR = 0.98, 95% CI: 0.58-1.65).The results of this large population-based cohort study supported the premise that women with PCOS might have an increased risk of endometrial cancer, but no association between PCOS and the risks of ovarian and breast cancer was found. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/30278576/Association_between_polycystic_ovarian_syndrome_and_endometrial_ovarian_and_breast_cancer:_A_population_based_cohort_study_in_Taiwan_ L2 - http://Insights.ovid.com/pubmed?pmid=30278576 DB - PRIME DP - Unbound Medicine ER -