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Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat.
Int J Mol Sci. 2018 Oct 02; 19(10)IJ

Abstract

Synthetic hexaploid wheat (SHW; 2n = 6x = 42, AABBDD, Triticum aestivum L.) is produced from an interspecific cross between durum wheat (2n = 4x = 28, AABB, T. turgidum L.) and goat grass (2n = 2x = 14, DD, Aegilops tauschii Coss.) and is reported to have significant novel alleles-controlling biotic and abiotic stresses resistance. A genome-wide association study (GWAS) was conducted to unravel these loci [marker⁻trait associations (MTAs)] using 35,648 genotyping-by-sequencing-derived single nucleotide polymorphisms in 123 SHWs. We identified 90 novel MTAs (45, 11, and 34 on the A, B, and D genomes, respectively) and haplotype blocks associated with grain yield and yield-related traits including root traits under drought stress. The phenotypic variance explained by the MTAs ranged from 1.1% to 32.3%. Most of the MTAs (120 out of 194) identified were found in genes, and of these 45 MTAs were in genes annotated as having a potential role in drought stress. This result provides further evidence for the reliability of MTAs identified. The large number of MTAs (53) identified especially on the D-genome demonstrate the potential of SHWs for elucidating the genetic architecture of complex traits and provide an opportunity for further improvement of wheat under rapidly changing climatic conditions.

Authors+Show Affiliations

Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. madhav.bhatta@huskers.unl.edu.International Maize and Wheat Improvement Center (CIMMYT), 06511 Emek, Ankara, Turkey. a.morgounov@cgiar.org.Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. vikas.belamkar@unl.edu.Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. pbaenziger1@unl.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30279375

Citation

Bhatta, Madhav, et al. "Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat." International Journal of Molecular Sciences, vol. 19, no. 10, 2018.
Bhatta M, Morgounov A, Belamkar V, et al. Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat. Int J Mol Sci. 2018;19(10).
Bhatta, M., Morgounov, A., Belamkar, V., & Baenziger, P. S. (2018). Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat. International Journal of Molecular Sciences, 19(10). https://doi.org/10.3390/ijms19103011
Bhatta M, et al. Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat. Int J Mol Sci. 2018 Oct 2;19(10) PubMed PMID: 30279375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-Wide Association Study Reveals Novel Genomic Regions for Grain Yield and Yield-Related Traits in Drought-Stressed Synthetic Hexaploid Wheat. AU - Bhatta,Madhav, AU - Morgounov,Alexey, AU - Belamkar,Vikas, AU - Baenziger,P Stephen, Y1 - 2018/10/02/ PY - 2018/08/20/received PY - 2018/09/27/revised PY - 2018/09/29/accepted PY - 2018/10/4/entrez PY - 2018/10/4/pubmed PY - 2019/1/23/medline KW - D-genome KW - bread wheat KW - complex traits KW - durum wheat KW - genes KW - genotyping-by-sequencing KW - haplotype block KW - marker–trait association KW - root traits KW - single nucleotide polymorphism JF - International journal of molecular sciences JO - Int J Mol Sci VL - 19 IS - 10 N2 - Synthetic hexaploid wheat (SHW; 2n = 6x = 42, AABBDD, Triticum aestivum L.) is produced from an interspecific cross between durum wheat (2n = 4x = 28, AABB, T. turgidum L.) and goat grass (2n = 2x = 14, DD, Aegilops tauschii Coss.) and is reported to have significant novel alleles-controlling biotic and abiotic stresses resistance. A genome-wide association study (GWAS) was conducted to unravel these loci [marker⁻trait associations (MTAs)] using 35,648 genotyping-by-sequencing-derived single nucleotide polymorphisms in 123 SHWs. We identified 90 novel MTAs (45, 11, and 34 on the A, B, and D genomes, respectively) and haplotype blocks associated with grain yield and yield-related traits including root traits under drought stress. The phenotypic variance explained by the MTAs ranged from 1.1% to 32.3%. Most of the MTAs (120 out of 194) identified were found in genes, and of these 45 MTAs were in genes annotated as having a potential role in drought stress. This result provides further evidence for the reliability of MTAs identified. The large number of MTAs (53) identified especially on the D-genome demonstrate the potential of SHWs for elucidating the genetic architecture of complex traits and provide an opportunity for further improvement of wheat under rapidly changing climatic conditions. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/30279375/Genome_Wide_Association_Study_Reveals_Novel_Genomic_Regions_for_Grain_Yield_and_Yield_Related_Traits_in_Drought_Stressed_Synthetic_Hexaploid_Wheat_ L2 - https://www.mdpi.com/resolver?pii=ijms19103011 DB - PRIME DP - Unbound Medicine ER -