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Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial.
Acta Derm Venereol. 2019 01 01; 99(1):53-57.AD

Abstract

Conventional treatment of cutaneous leishmaniasis often leaves permanent scars with frequent psychosocial sequelae. The aim of this study was to compare the efficacy, safety, associated pain and final cosmetic outcome of fractional carbon dioxide (CO2) laser followed by topical application of sodium stibogluconate vs. sodium stibogluconate injections for the treatment of cutaneous leishmaniasis. A total of 181 lesions (20 patients) were randomly assigned to receive intralesional injections of sodium stibogluconate (control group) or fractional CO2 laser treatment followed by topical application of sodium stibogluconate (study group). The visual analogue scale (VAS) score of the control group was much higher than that of the study group (6.85 vs. 3.5, respectively, p<0.001). Both the patients and 2 blinded dermatologists found the final cosmetic outcome to be superior for laser-treated lesions (p = 0.001 vs. p =0.008 for controls). Fractional CO2 laser treatment followed by topical application of sodium stibogluconate is less painful and leads to a better final cosmetic outcome compared with intralesional injections of sodium stibogluconate.

Authors+Show Affiliations

Department of Dermatology, Tel Aviv Medical Center, Tel Aviv, 6423906, Israel. benofir@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30281141

Citation

Artzi, Ofir, et al. "Fractional Ablative CO2 Laser Followed By Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: a Randomized Controlled Trial." Acta Dermato-venereologica, vol. 99, no. 1, 2019, pp. 53-57.
Artzi O, Sprecher E, Koren A, et al. Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial. Acta Derm Venereol. 2019;99(1):53-57.
Artzi, O., Sprecher, E., Koren, A., Mehrabi, J. N., Katz, O., & Hilerowich, Y. (2019). Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial. Acta Dermato-venereologica, 99(1), 53-57. https://doi.org/10.2340/00015555-3058
Artzi O, et al. Fractional Ablative CO2 Laser Followed By Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: a Randomized Controlled Trial. Acta Derm Venereol. 2019 01 1;99(1):53-57. PubMed PMID: 30281141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fractional Ablative CO2 Laser Followed by Topical Application of Sodium Stibogluconate for Treatment of Active Cutaneous Leishmaniasis: A Randomized Controlled Trial. AU - Artzi,Ofir, AU - Sprecher,Eli, AU - Koren,Amir, AU - Mehrabi,Joseph N, AU - Katz,Oren, AU - Hilerowich,Yuval, PY - 2018/10/4/pubmed PY - 2019/4/23/medline PY - 2018/10/4/entrez KW - cutaneous leishmaniasis KW - carbon dioxide KW - ablative fractional laser KW - drug delivery SP - 53 EP - 57 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 99 IS - 1 N2 - Conventional treatment of cutaneous leishmaniasis often leaves permanent scars with frequent psychosocial sequelae. The aim of this study was to compare the efficacy, safety, associated pain and final cosmetic outcome of fractional carbon dioxide (CO2) laser followed by topical application of sodium stibogluconate vs. sodium stibogluconate injections for the treatment of cutaneous leishmaniasis. A total of 181 lesions (20 patients) were randomly assigned to receive intralesional injections of sodium stibogluconate (control group) or fractional CO2 laser treatment followed by topical application of sodium stibogluconate (study group). The visual analogue scale (VAS) score of the control group was much higher than that of the study group (6.85 vs. 3.5, respectively, p<0.001). Both the patients and 2 blinded dermatologists found the final cosmetic outcome to be superior for laser-treated lesions (p = 0.001 vs. p =0.008 for controls). Fractional CO2 laser treatment followed by topical application of sodium stibogluconate is less painful and leads to a better final cosmetic outcome compared with intralesional injections of sodium stibogluconate. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/30281141/Fractional_Ablative_CO2_Laser_Followed_by_Topical_Application_of_Sodium_Stibogluconate_for_Treatment_of_Active_Cutaneous_Leishmaniasis:_A_Randomized_Controlled_Trial_ DB - PRIME DP - Unbound Medicine ER -