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Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis.
J Basic Clin Physiol Pharmacol. 2018 Oct 02; 30(2):153-162.JB

Abstract

Wernicke encephalopathy (WE) and Korsakoff psychosis (KP), together termed Wernicke-Korsakoff syndrome (WKS), are distinct yet overlapping neuropsychiatric disorders associated with thiamine deficiency. Thiamine pyrophosphate, the biologically active form of thiamine, is essential for multiple biochemical pathways involved in carbohydrate utilization. Both genetic susceptibilities and acquired deficiencies as a result of alcoholic and non-alcoholic factors are associated with thiamine deficiency or its impaired utilization. WKS is underdiagnosed because of the inconsistent clinical presentation and overlapping of symptoms with other neurological conditions. The identification and individualized treatment of WE based on the etiology is vital to prevent the development of the amnestic state associated with KP in genetically predisposed individuals. Through this review, we bring together the existing data from animal and human models to expound the etiopathogenesis, diagnosis, and therapeutic interventions for WE and KP.

Authors+Show Affiliations

Clinical Research Unit, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.Clinical Research Unit, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada.Clinical Research Unit, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada. Department of Pediatrics, University of Manitoba, Winnipeg, Canada, Phone: +1 204 480 1328, Fax: +1 204 789 3907.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30281514

Citation

Chandrakumar, Abin, et al. "Review of Thiamine Deficiency Disorders: Wernicke Encephalopathy and Korsakoff Psychosis." Journal of Basic and Clinical Physiology and Pharmacology, vol. 30, no. 2, 2018, pp. 153-162.
Chandrakumar A, Bhardwaj A, 't Jong GW. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol. 2018;30(2):153-162.
Chandrakumar, A., Bhardwaj, A., & 't Jong, G. W. (2018). Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. Journal of Basic and Clinical Physiology and Pharmacology, 30(2), 153-162. https://doi.org/10.1515/jbcpp-2018-0075
Chandrakumar A, Bhardwaj A, 't Jong GW. Review of Thiamine Deficiency Disorders: Wernicke Encephalopathy and Korsakoff Psychosis. J Basic Clin Physiol Pharmacol. 2018 Oct 2;30(2):153-162. PubMed PMID: 30281514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. AU - Chandrakumar,Abin, AU - Bhardwaj,Aseem, AU - 't Jong,Geert W, Y1 - 2018/10/02/ PY - 2018/04/20/received PY - 2018/07/09/accepted PY - 2018/10/4/pubmed PY - 2019/7/25/medline PY - 2018/10/4/entrez KW - alcohol-related brain disorders KW - alcoholism KW - memory KW - neurodegeneration KW - thiamine SP - 153 EP - 162 JF - Journal of basic and clinical physiology and pharmacology JO - J Basic Clin Physiol Pharmacol VL - 30 IS - 2 N2 - Wernicke encephalopathy (WE) and Korsakoff psychosis (KP), together termed Wernicke-Korsakoff syndrome (WKS), are distinct yet overlapping neuropsychiatric disorders associated with thiamine deficiency. Thiamine pyrophosphate, the biologically active form of thiamine, is essential for multiple biochemical pathways involved in carbohydrate utilization. Both genetic susceptibilities and acquired deficiencies as a result of alcoholic and non-alcoholic factors are associated with thiamine deficiency or its impaired utilization. WKS is underdiagnosed because of the inconsistent clinical presentation and overlapping of symptoms with other neurological conditions. The identification and individualized treatment of WE based on the etiology is vital to prevent the development of the amnestic state associated with KP in genetically predisposed individuals. Through this review, we bring together the existing data from animal and human models to expound the etiopathogenesis, diagnosis, and therapeutic interventions for WE and KP. SN - 2191-0286 UR - https://www.unboundmedicine.com/medline/citation/30281514/Review_of_thiamine_deficiency_disorders:_Wernicke_encephalopathy_and_Korsakoff_psychosis_ L2 - https://www.degruyter.com/document/doi/10.1515/jbcpp-2018-0075 DB - PRIME DP - Unbound Medicine ER -