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Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats.
Biomed Biochim Acta. 1986; 45(9):1167-72.BB

Abstract

With regard to the still debatable effect of lithium in epilepsy the effect of chronic lithium treatment on the development of pentylenetetrazol(PTZ)-kindling and the anti-convulsive potency of acute lithium administration on PTZ-induced seizure behaviour in PTZ-kindled and non-kindled rats was examined. Lithium significantly suppressed the development of PTZ-kindling. In kindled rats the acute application of lithium reduced seizure susceptibility in a dose-dependent manner. In contrast to kindled rats, in non-kindled animals lithium had very weak anticonvulsive potency. The results suggest that lithium may be of potential interest in the treatment of special forms of epilepsy and epileptic brain disorders.

Authors

Schmidt J
No affiliation info available

MeSH

AnimalsChloridesDisease SusceptibilityFemaleKindling, NeurologicLithiumLithium ChloridePentylenetetrazoleRatsRats, Inbred StrainsSeizures

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3028380

Citation

Schmidt, J. "Lithium Suppresses Seizure Susceptibility in Pentylenetetrazol-kindled Rats." Biomedica Biochimica Acta, vol. 45, no. 9, 1986, pp. 1167-72.
Schmidt J. Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats. Biomed Biochim Acta. 1986;45(9):1167-72.
Schmidt, J. (1986). Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats. Biomedica Biochimica Acta, 45(9), 1167-72.
Schmidt J. Lithium Suppresses Seizure Susceptibility in Pentylenetetrazol-kindled Rats. Biomed Biochim Acta. 1986;45(9):1167-72. PubMed PMID: 3028380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats. A1 - Schmidt,J, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 1167 EP - 72 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 45 IS - 9 N2 - With regard to the still debatable effect of lithium in epilepsy the effect of chronic lithium treatment on the development of pentylenetetrazol(PTZ)-kindling and the anti-convulsive potency of acute lithium administration on PTZ-induced seizure behaviour in PTZ-kindled and non-kindled rats was examined. Lithium significantly suppressed the development of PTZ-kindling. In kindled rats the acute application of lithium reduced seizure susceptibility in a dose-dependent manner. In contrast to kindled rats, in non-kindled animals lithium had very weak anticonvulsive potency. The results suggest that lithium may be of potential interest in the treatment of special forms of epilepsy and epileptic brain disorders. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/3028380/Lithium_suppresses_seizure_susceptibility_in_pentylenetetrazol_kindled_rats_ DB - PRIME DP - Unbound Medicine ER -