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Thermo-activated peroxydisulfate oxidation of indomethacin: Kinetics study and influences of co-existing substances.
Chemosphere. 2018 Dec; 212:1067-1075.C

Abstract

The widespread occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., Indomethacin) in the ambient environment has attracted growing concerns due to their potential threats to ecosystems and human health. Herein, we investigated the degradation of indomethacin (IM) by thermo-activated peroxydisulfate (PDS). The pseudo first-order rate constant (kobs) of degradation of IM was increased significantly with higher temperatures and PDS doses. Moreover, when the initial pH value was raised from 5 to 9 the IM degradation was initially decreased and then increased. Basic conditions were favorable for the removal of IM in the thermo-activated peroxydisulfate system. A response surface methodology based on the Box-Behnken design (BBD) was successfully employed for the optimization of the thermo-activated peroxydisulfate (PDS) system. The presence of chlorine ions manifested a dual effect on the degradation of IM, while bicarbonate and SRFA (as a NOM model) reduced it. Radical scavenging tests and electron spin resonance (ESR) revealed that the dominant oxidizing species were SO4- and OH at pH 9. Furthermore, the TOC removal efficiency attained 28.8% and the release of Cl-was 38.5% at 60 °C within 24min, while the mineralization rate of IM were 85.5% with the PDS concentration up to 20 mM at 2 h oxidation. To summarize, thermo-activated PDS oxidation is a promising technique for the remediation of IM-contaminated water.

Authors+Show Affiliations

School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.School of Environment, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang, 453007, China.School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address: liugg615@163.com.School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30286536

Citation

Li, Ruobai, et al. "Thermo-activated Peroxydisulfate Oxidation of Indomethacin: Kinetics Study and Influences of Co-existing Substances." Chemosphere, vol. 212, 2018, pp. 1067-1075.
Li R, Cai M, Liu H, et al. Thermo-activated peroxydisulfate oxidation of indomethacin: Kinetics study and influences of co-existing substances. Chemosphere. 2018;212:1067-1075.
Li, R., Cai, M., Liu, H., Liu, G., & Lv, W. (2018). Thermo-activated peroxydisulfate oxidation of indomethacin: Kinetics study and influences of co-existing substances. Chemosphere, 212, 1067-1075. https://doi.org/10.1016/j.chemosphere.2018.08.126
Li R, et al. Thermo-activated Peroxydisulfate Oxidation of Indomethacin: Kinetics Study and Influences of Co-existing Substances. Chemosphere. 2018;212:1067-1075. PubMed PMID: 30286536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thermo-activated peroxydisulfate oxidation of indomethacin: Kinetics study and influences of co-existing substances. AU - Li,Ruobai, AU - Cai,Meixuan, AU - Liu,Haijin, AU - Liu,Guoguang, AU - Lv,Wenying, Y1 - 2018/08/29/ PY - 2018/04/21/received PY - 2018/08/02/revised PY - 2018/08/24/accepted PY - 2018/10/6/entrez PY - 2018/10/6/pubmed PY - 2018/11/20/medline KW - Box-behnken design KW - Dechlorination KW - Mineralization KW - Reactive radicals KW - Thermo-activated persulfate SP - 1067 EP - 1075 JF - Chemosphere JO - Chemosphere VL - 212 N2 - The widespread occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., Indomethacin) in the ambient environment has attracted growing concerns due to their potential threats to ecosystems and human health. Herein, we investigated the degradation of indomethacin (IM) by thermo-activated peroxydisulfate (PDS). The pseudo first-order rate constant (kobs) of degradation of IM was increased significantly with higher temperatures and PDS doses. Moreover, when the initial pH value was raised from 5 to 9 the IM degradation was initially decreased and then increased. Basic conditions were favorable for the removal of IM in the thermo-activated peroxydisulfate system. A response surface methodology based on the Box-Behnken design (BBD) was successfully employed for the optimization of the thermo-activated peroxydisulfate (PDS) system. The presence of chlorine ions manifested a dual effect on the degradation of IM, while bicarbonate and SRFA (as a NOM model) reduced it. Radical scavenging tests and electron spin resonance (ESR) revealed that the dominant oxidizing species were SO4- and OH at pH 9. Furthermore, the TOC removal efficiency attained 28.8% and the release of Cl-was 38.5% at 60 °C within 24min, while the mineralization rate of IM were 85.5% with the PDS concentration up to 20 mM at 2 h oxidation. To summarize, thermo-activated PDS oxidation is a promising technique for the remediation of IM-contaminated water. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/30286536/Thermo_activated_peroxydisulfate_oxidation_of_indomethacin:_Kinetics_study_and_influences_of_co_existing_substances_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(18)31601-1 DB - PRIME DP - Unbound Medicine ER -