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Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length.
Acta Ophthalmol. 2019 May; 97(3):e454-e459.AO

Abstract

PURPOSE

To investigate changes in subfoveal choroidal thickness (SFChT) during orthokeratology (Ortho-K) lens wear and after its cessation and the association of short-term change in SFChT with the long-term eye elongation in Ortho-K subjects.

DESIGN

A prospective clinical trial.

METHODS

Fifty myopic children aged between 9 and 14 years were enrolled. Twenty-nine subjects continuously wore Ortho-K lens for 12 months and discontinued for 1 month. Twenty-one subjects wearing single vision distance spectacles for 12 months were included as the control group. SFChT was assessed using optical coherence tomography. Ocular parameters, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and apical corneal power (ACP), were also measured.

RESULTS

After 12 months of follow-up, AL elongation was larger and SFChT change was smaller in the control group compared to the Ortho-K group (both p < 0.001). In the Ortho-K group, SFChT increased by 16 μm from baseline at the 1-month visit (p < 0.001), and the magnitude of choroidal thickening remained unchanged at the 6- and 12-month visit (p = 0.289). One month after discontinuation of Ortho-K lens, SFChT and ocular parameters of the anterior segment, including ACP, CCT and ACD recovered to baseline level (All p > 0.05), and AL increased by 0.23 ± 0.18 mm compared to baseline (p = 0.018). SFChT change at 1-month was negatively associated with AL change at 13-month (standard β, -0.581, p = 0.001) after adjusting for other influencing factors, including baseline age and the ocular parameters.

CONCLUSION

Subfoveal ChT (SFChT) significantly increased after short-term Ortho-K lens treatment and the increase maintained throughout the period of treatment. One month after Ortho-K lens cessation, SFChT, ACP, CCT and ACD returned to baseline. Short-term response in SFChT is associated with long-term change in AL in children undergoing Ortho-K lens and may be a predictor for the effectiveness of the treatment.

Authors+Show Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VIC, Australia.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

30288939

Citation

Li, Zhouyue, et al. "Change in Subfoveal Choroidal Thickness Secondary to Orthokeratology and Its Cessation: a Predictor for the Change in Axial Length." Acta Ophthalmologica, vol. 97, no. 3, 2019, pp. e454-e459.
Li Z, Hu Y, Cui D, et al. Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length. Acta Ophthalmol. 2019;97(3):e454-e459.
Li, Z., Hu, Y., Cui, D., Long, W., He, M., & Yang, X. (2019). Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length. Acta Ophthalmologica, 97(3), e454-e459. https://doi.org/10.1111/aos.13866
Li Z, et al. Change in Subfoveal Choroidal Thickness Secondary to Orthokeratology and Its Cessation: a Predictor for the Change in Axial Length. Acta Ophthalmol. 2019;97(3):e454-e459. PubMed PMID: 30288939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Change in subfoveal choroidal thickness secondary to orthokeratology and its cessation: a predictor for the change in axial length. AU - Li,Zhouyue, AU - Hu,Yin, AU - Cui,Dongmei, AU - Long,Wen, AU - He,Mingguang, AU - Yang,Xiao, Y1 - 2018/10/04/ PY - 2017/12/06/received PY - 2018/06/01/accepted PY - 2018/10/6/pubmed PY - 2019/4/25/medline PY - 2018/10/6/entrez KW - SD-OCT KW - choroidal thickness KW - myopia KW - orthokeratology SP - e454 EP - e459 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 97 IS - 3 N2 - PURPOSE: To investigate changes in subfoveal choroidal thickness (SFChT) during orthokeratology (Ortho-K) lens wear and after its cessation and the association of short-term change in SFChT with the long-term eye elongation in Ortho-K subjects. DESIGN: A prospective clinical trial. METHODS: Fifty myopic children aged between 9 and 14 years were enrolled. Twenty-nine subjects continuously wore Ortho-K lens for 12 months and discontinued for 1 month. Twenty-one subjects wearing single vision distance spectacles for 12 months were included as the control group. SFChT was assessed using optical coherence tomography. Ocular parameters, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and apical corneal power (ACP), were also measured. RESULTS: After 12 months of follow-up, AL elongation was larger and SFChT change was smaller in the control group compared to the Ortho-K group (both p < 0.001). In the Ortho-K group, SFChT increased by 16 μm from baseline at the 1-month visit (p < 0.001), and the magnitude of choroidal thickening remained unchanged at the 6- and 12-month visit (p = 0.289). One month after discontinuation of Ortho-K lens, SFChT and ocular parameters of the anterior segment, including ACP, CCT and ACD recovered to baseline level (All p > 0.05), and AL increased by 0.23 ± 0.18 mm compared to baseline (p = 0.018). SFChT change at 1-month was negatively associated with AL change at 13-month (standard β, -0.581, p = 0.001) after adjusting for other influencing factors, including baseline age and the ocular parameters. CONCLUSION: Subfoveal ChT (SFChT) significantly increased after short-term Ortho-K lens treatment and the increase maintained throughout the period of treatment. One month after Ortho-K lens cessation, SFChT, ACP, CCT and ACD returned to baseline. Short-term response in SFChT is associated with long-term change in AL in children undergoing Ortho-K lens and may be a predictor for the effectiveness of the treatment. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/30288939/Change_in_subfoveal_choroidal_thickness_secondary_to_orthokeratology_and_its_cessation:_a_predictor_for_the_change_in_axial_length_ L2 - https://doi.org/10.1111/aos.13866 DB - PRIME DP - Unbound Medicine ER -