Citation
Sharma, Vijay K., et al. "Rationale and Design of a Randomized Trial of Early Intensive Blood Pressure Lowering On Cerebral Perfusion Parameters in Thrombolysed Acute Ischemic Stroke Patients." Medicine, vol. 97, no. 40, 2018, pp. e12721.
Sharma VK, Tan BYQ, Sim MY, et al. Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients. Medicine (Baltimore). 2018;97(40):e12721.
Sharma, V. K., Tan, B. Y. Q., Sim, M. Y., Kulkarni, A., Seow, P. A., Hong, C. S., Du, Z., Wong, L. Y. H., Chen, J., Chee, E. Y. H., Ng, B. S. M., Low, Y., Ngiam, N. J. H., Yeo, L. L. L., Teoh, H. L., Paliwal, P. R., Rathakrishnan, R., Sinha, A. K., Chan, B. P. L., ... Anderson, C. S. (2018). Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients. Medicine, 97(40), e12721. https://doi.org/10.1097/MD.0000000000012721
Sharma VK, et al. Rationale and Design of a Randomized Trial of Early Intensive Blood Pressure Lowering On Cerebral Perfusion Parameters in Thrombolysed Acute Ischemic Stroke Patients. Medicine (Baltimore). 2018;97(40):e12721. PubMed PMID: 30290680.
TY - JOUR
T1 - Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.
AU - Sharma,Vijay K,
AU - Tan,Benjamin Y Q,
AU - Sim,M Ying,
AU - Kulkarni,Amit,
AU - Seow,Philip A,
AU - Hong,Chiew S,
AU - Du,Zhengdao,
AU - Wong,Lily Y H,
AU - Chen,Jintao,
AU - Chee,Elaine Y H,
AU - Ng,Bridget S M,
AU - Low,Yingliang,
AU - Ngiam,Nicholas J H,
AU - Yeo,Leonard L L,
AU - Teoh,Hock L,
AU - Paliwal,Prakash R,
AU - Rathakrishnan,Rahul,
AU - Sinha,Arvind K,
AU - Chan,Bernard P L,
AU - Butcher,Kenneth,
AU - Anderson,Craig S,
PY - 2018/10/7/entrez
PY - 2018/10/7/pubmed
PY - 2018/10/13/medline
SP - e12721
EP - e12721
JF - Medicine
JO - Medicine (Baltimore)
VL - 97
IS - 40
N2 - BACKGROUND AND RATIONALE: Uncertainty persists over the optimal management of blood pressure (BP) in the early phase of acute ischemic stroke (AIS). This study aims to determine the safety and effects of intensive BP lowering on cerebral blood flow (CBF) and functional in AIS patients treated with intravenous thrombolysis. METHODS: In a randomized controlled trial, 54 thrombolysed AIS patients with a systolic BP of 160 to 180 mm Hg will be randomized to early intensive BP lowering (systolic target range 140-160 mm Hg) or guideline-based BP management (systolic range 160-180 mm Hg) during first 72-hours using primarily intravenous labetalol. We hypothesize that early intensive BP lowering will not reduce CBF by 20% and/or increase the volume of hypoperfused tissue by >20% on computed tomographic perfusion. Clinical outcome will be assessed using a dichotomized modified Rankin scale (scores 0-1 as excellent outcome vs scores 2-6 as dead or dependent) at 90 days. Other outcome would be symptomatic intracerebral hemorrhage. The trial is registered at ClinicalTrials.gov, NCT03443596. CONCLUSION: This randomized study will provide important information about the physiological effects of BP reduction on cerebral perfusion after intravenous thrombolysis in AIS.
SN - 1536-5964
UR - https://www.unboundmedicine.com/medline/citation/30290680/Rationale_and_design_of_a_randomized_trial_of_early_intensive_blood_pressure_lowering_on_cerebral_perfusion_parameters_in_thrombolysed_acute_ischemic_stroke_patients_
DB - PRIME
DP - Unbound Medicine
ER -
