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"Tupanvirus", a new genus in the family Mimiviridae.
Arch Virol. 2019 Jan; 164(1):325-331.AV

Abstract

The genus "Tupanvirus" is a new proposed taxon to be included in the family Mimiviridae. The two known tupanvirus isolates were isolated from soda lake and oceanic sediments samples collected in Brazil and were named "tupanvirus soda lake" and "tupanvirus deep ocean", respectively. These viruses exhibit similarities to amoeba-infecting mimiviruses, but there are also several differences that place them in a separate group within the family Mimiviridae. Their virions have a mean size of 1.2 µm, which include a mimivirus-like capsid and a large cylindrical tail, both covered by fibrils. The linear double-stranded DNA genomes of up to 1,516,267 base pairs encode over 1,200 genes, among which ~ 30% have no homologs in any database, including in other mimivirus genomes. Compared to other mimiviruses, tupanviruses exhibit a broader host range and cause a cytotoxic effect in host and non-host organisms, a phenotype that is not observed for other mimiviruses. Remarkably, these viruses possess the most complete gene set related to the protein synthesis process, including 20 aminoacyl-tRNA synthetases, 67-70 tRNAs, many translation factors, and genes involved in maturation and modification of tRNA and mRNA, among others. Moreover, diverse phylogenomic analyses put tupanviruses in a distinct group within the family Mimiviridae. In light of the set of different features observed for these giant viruses, we propose establishment of a new genus to allow proper classification of two known tupanviruses and possibly many more similar viruses yet to be characterized.

Authors+Show Affiliations

Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France. Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.Aix-Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France.Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. jonatas.abrahao@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30291500

Citation

Rodrigues, Rodrigo Araújo Lima, et al. ""Tupanvirus", a New Genus in the Family Mimiviridae." Archives of Virology, vol. 164, no. 1, 2019, pp. 325-331.
Rodrigues RAL, Mougari S, Colson P, et al. "Tupanvirus", a new genus in the family Mimiviridae. Arch Virol. 2019;164(1):325-331.
Rodrigues, R. A. L., Mougari, S., Colson, P., La Scola, B., & Abrahão, J. S. (2019). "Tupanvirus", a new genus in the family Mimiviridae. Archives of Virology, 164(1), 325-331. https://doi.org/10.1007/s00705-018-4067-4
Rodrigues RAL, et al. "Tupanvirus", a New Genus in the Family Mimiviridae. Arch Virol. 2019;164(1):325-331. PubMed PMID: 30291500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - "Tupanvirus", a new genus in the family Mimiviridae. AU - Rodrigues,Rodrigo Araújo Lima, AU - Mougari,Said, AU - Colson,Phillipe, AU - La Scola,Bernard, AU - Abrahão,Jônatas Santos, Y1 - 2018/10/05/ PY - 2018/07/06/received PY - 2018/09/30/accepted PY - 2018/10/7/pubmed PY - 2019/2/6/medline PY - 2018/10/7/entrez SP - 325 EP - 331 JF - Archives of virology JO - Arch Virol VL - 164 IS - 1 N2 - The genus "Tupanvirus" is a new proposed taxon to be included in the family Mimiviridae. The two known tupanvirus isolates were isolated from soda lake and oceanic sediments samples collected in Brazil and were named "tupanvirus soda lake" and "tupanvirus deep ocean", respectively. These viruses exhibit similarities to amoeba-infecting mimiviruses, but there are also several differences that place them in a separate group within the family Mimiviridae. Their virions have a mean size of 1.2 µm, which include a mimivirus-like capsid and a large cylindrical tail, both covered by fibrils. The linear double-stranded DNA genomes of up to 1,516,267 base pairs encode over 1,200 genes, among which ~ 30% have no homologs in any database, including in other mimivirus genomes. Compared to other mimiviruses, tupanviruses exhibit a broader host range and cause a cytotoxic effect in host and non-host organisms, a phenotype that is not observed for other mimiviruses. Remarkably, these viruses possess the most complete gene set related to the protein synthesis process, including 20 aminoacyl-tRNA synthetases, 67-70 tRNAs, many translation factors, and genes involved in maturation and modification of tRNA and mRNA, among others. Moreover, diverse phylogenomic analyses put tupanviruses in a distinct group within the family Mimiviridae. In light of the set of different features observed for these giant viruses, we propose establishment of a new genus to allow proper classification of two known tupanviruses and possibly many more similar viruses yet to be characterized. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/30291500/"Tupanvirus"_a_new_genus_in_the_family_Mimiviridae_ L2 - https://dx.doi.org/10.1007/s00705-018-4067-4 DB - PRIME DP - Unbound Medicine ER -