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Beneficial effects of anodal transcranial direct current stimulation (tDCS) on spatial working memory in patients with schizophrenia.
Eur Neuropsychopharmacol 2018; 28(12):1339-1350EN

Abstract

Schizophrenia is a severe and often detrimental psychiatric disorder. The individual patients' level of functioning is essentially determined by cognitive, particularly working memory (WM), deficits that are critically linked to dysfunctional activity of the dorsolateral prefrontal cortex (dlPFC). Transcranial direct current stimulation (tDCS) can transiently modulate activity of the dlPFC and remote areas and has been shown to improve WM functions. It may therefore provide a new, targeted treatment option. For this aim, the present study investigated the effect of anodal tDCS of different intensities on spatial WM in patients with schizophrenia. In two experiments, 32 patients performed a spatial n-back task with increasing WM load (1-, 2-, and 3-back) at baseline and in two sessions with anodal or sham tDCS (EXP I [n = 16]: 1 mA; EXP II [n = 16]: 2 mA) to the right dlPFC (cathode: left m. deltoideus). With 1 mA anodal tDCS, no effect on WM performance could be detected. However, 2 mA anodal tDCS increased accuracy (measured by d') of the task with the highest WM load (3-back). This effect was larger in patients with a lower level of general neurocognitive functioning. These results demonstrate a beneficial effect of 2 mA anodal tDCS on deficient WM accuracy in patients with schizophrenia particularly under challenging conditions and in subjects with higher cognitive impairments. This data will inform future clinical trials on tDCS-enhanced cognitive training to improve treatment of schizophrenia.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Calwerstrasse 14, 72076 Tübingen, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians University Munich, Nuβbaumstraβe 7, 80336 Munich, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians University Munich, Nuβbaumstraβe 7, 80336 Munich, Germany.Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Calwerstrasse 14, 72076 Tübingen, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians University Munich, Nuβbaumstraβe 7, 80336 Munich, Germany.Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Calwerstrasse 14, 72076 Tübingen, Germany. Electronic address: christian.plewnia@uni-tuebingen.de.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30292415

Citation

Schwippel, T, et al. "Beneficial Effects of Anodal Transcranial Direct Current Stimulation (tDCS) On Spatial Working Memory in Patients With Schizophrenia." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 28, no. 12, 2018, pp. 1339-1350.
Schwippel T, Papazova I, Strube W, et al. Beneficial effects of anodal transcranial direct current stimulation (tDCS) on spatial working memory in patients with schizophrenia. Eur Neuropsychopharmacol. 2018;28(12):1339-1350.
Schwippel, T., Papazova, I., Strube, W., Fallgatter, A. J., Hasan, A., & Plewnia, C. (2018). Beneficial effects of anodal transcranial direct current stimulation (tDCS) on spatial working memory in patients with schizophrenia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 28(12), pp. 1339-1350. doi:10.1016/j.euroneuro.2018.09.009.
Schwippel T, et al. Beneficial Effects of Anodal Transcranial Direct Current Stimulation (tDCS) On Spatial Working Memory in Patients With Schizophrenia. Eur Neuropsychopharmacol. 2018;28(12):1339-1350. PubMed PMID: 30292415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of anodal transcranial direct current stimulation (tDCS) on spatial working memory in patients with schizophrenia. AU - Schwippel,T, AU - Papazova,I, AU - Strube,W, AU - Fallgatter,A J, AU - Hasan,A, AU - Plewnia,C, Y1 - 2018/10/03/ PY - 2017/12/01/received PY - 2018/03/23/revised PY - 2018/09/21/accepted PY - 2018/10/8/pubmed PY - 2019/6/14/medline PY - 2018/10/8/entrez KW - Brain stimulation KW - Cognition KW - Schizophrenia KW - Therapy KW - Transcranial direct current stimulation KW - Working memory SP - 1339 EP - 1350 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 28 IS - 12 N2 - Schizophrenia is a severe and often detrimental psychiatric disorder. The individual patients' level of functioning is essentially determined by cognitive, particularly working memory (WM), deficits that are critically linked to dysfunctional activity of the dorsolateral prefrontal cortex (dlPFC). Transcranial direct current stimulation (tDCS) can transiently modulate activity of the dlPFC and remote areas and has been shown to improve WM functions. It may therefore provide a new, targeted treatment option. For this aim, the present study investigated the effect of anodal tDCS of different intensities on spatial WM in patients with schizophrenia. In two experiments, 32 patients performed a spatial n-back task with increasing WM load (1-, 2-, and 3-back) at baseline and in two sessions with anodal or sham tDCS (EXP I [n = 16]: 1 mA; EXP II [n = 16]: 2 mA) to the right dlPFC (cathode: left m. deltoideus). With 1 mA anodal tDCS, no effect on WM performance could be detected. However, 2 mA anodal tDCS increased accuracy (measured by d') of the task with the highest WM load (3-back). This effect was larger in patients with a lower level of general neurocognitive functioning. These results demonstrate a beneficial effect of 2 mA anodal tDCS on deficient WM accuracy in patients with schizophrenia particularly under challenging conditions and in subjects with higher cognitive impairments. This data will inform future clinical trials on tDCS-enhanced cognitive training to improve treatment of schizophrenia. SN - 1873-7862 UR - https://www.unboundmedicine.com/medline/citation/30292415/Beneficial_effects_of_anodal_transcranial_direct_current_stimulation__tDCS__on_spatial_working_memory_in_patients_with_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0924-977X(18)30835-6 DB - PRIME DP - Unbound Medicine ER -