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A neural mechanism of direct and observational conditioning for placebo and nocebo responses.
Neuroimage. 2019 01 01; 184:954-963.N

Abstract

Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas the neural mechanism of how expectation modulates placebo and nocebo effects during pain anticipation have been extensively studied, little is known about how experience may change brain networks to produce placebo and nocebo responses. We investigated the neural pathways of direct and observational conditioning for conscious and nonconscious conditioned placebo/nocebo effects using magnetoencephalography and a face visual cue conditioning model. We found that both direct and observational conditioning produced conscious conditioned placebo and nocebo effects and a nonconscious conditioned nocebo effect. Alpha band brain connectivity changes before and after conditioning could predict the magnitude of conditioned placebo and nocebo effects. Particularly, the connectivity between the rostral anterior cingulate cortex and middle temporal gyrus was an important indicator for the manipulation of placebo and nocebo effects. Our study suggests that conditioning can mediate our pain experience by encoding experience and modulating brain networks.

Authors+Show Affiliations

Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Melbourne School of Psychological Sciences, University of Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, Australia.Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. Electronic address: kongj@nmr.mgh.harvard.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30296557

Citation

Tu, Yiheng, et al. "A Neural Mechanism of Direct and Observational Conditioning for Placebo and Nocebo Responses." NeuroImage, vol. 184, 2019, pp. 954-963.
Tu Y, Park J, Ahlfors SP, et al. A neural mechanism of direct and observational conditioning for placebo and nocebo responses. Neuroimage. 2019;184:954-963.
Tu, Y., Park, J., Ahlfors, S. P., Khan, S., Egorova, N., Lang, C., Cao, J., & Kong, J. (2019). A neural mechanism of direct and observational conditioning for placebo and nocebo responses. NeuroImage, 184, 954-963. https://doi.org/10.1016/j.neuroimage.2018.10.020
Tu Y, et al. A Neural Mechanism of Direct and Observational Conditioning for Placebo and Nocebo Responses. Neuroimage. 2019 01 1;184:954-963. PubMed PMID: 30296557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A neural mechanism of direct and observational conditioning for placebo and nocebo responses. AU - Tu,Yiheng, AU - Park,Joel, AU - Ahlfors,Seppo P, AU - Khan,Sheraz, AU - Egorova,Natalia, AU - Lang,Courtney, AU - Cao,Jin, AU - Kong,Jian, Y1 - 2018/10/06/ PY - 2018/06/13/received PY - 2018/09/24/revised PY - 2018/10/05/accepted PY - 2018/10/9/pubmed PY - 2019/2/5/medline PY - 2018/10/9/entrez KW - Alpha band connectivity KW - Conditioning KW - Consciousness KW - Learning KW - Placebo KW - Rostral anterior cingulate cortex SP - 954 EP - 963 JF - NeuroImage JO - Neuroimage VL - 184 N2 - Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas the neural mechanism of how expectation modulates placebo and nocebo effects during pain anticipation have been extensively studied, little is known about how experience may change brain networks to produce placebo and nocebo responses. We investigated the neural pathways of direct and observational conditioning for conscious and nonconscious conditioned placebo/nocebo effects using magnetoencephalography and a face visual cue conditioning model. We found that both direct and observational conditioning produced conscious conditioned placebo and nocebo effects and a nonconscious conditioned nocebo effect. Alpha band brain connectivity changes before and after conditioning could predict the magnitude of conditioned placebo and nocebo effects. Particularly, the connectivity between the rostral anterior cingulate cortex and middle temporal gyrus was an important indicator for the manipulation of placebo and nocebo effects. Our study suggests that conditioning can mediate our pain experience by encoding experience and modulating brain networks. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/30296557/A_neural_mechanism_of_direct_and_observational_conditioning_for_placebo_and_nocebo_responses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(18)31979-7 DB - PRIME DP - Unbound Medicine ER -