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Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose⁻Response Randomized Placebo-Controlled Trial.
Nutrients 2018; 10(10)N

Abstract

Omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation has been shown to improve plasma lipid profiles in men and post-menopausal women, however, data for pre-menopausal women are lacking. The benefits of intakes less than 1 g/day have not been well studied, and dose⁻response data is limited. The aim of this study was to determine the effect of low doses of docosahexaenoic acid (DHA)-rich tuna oil on plasma triglyceride (TG) lowering in pre-menopausal women, and investigate if low dose DHA-rich tuna oil supplementation would increase the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle sizes. A randomized, double-blind, placebo-controlled trial was conducted, in which 53 healthy pre-menopausal women with mildly elevated plasma TG levels consumed 0, 0.35, 0.7, or 1 g/day n-3 LCPUFA as HiDHA™ tuna oil or placebo (Sunola oil) capsules for 8 weeks. Supplementation with 1 g/day n-3 LCPUFA, but not lower doses, reduced plasma TG by 23% in pre-menopausal women. This was reflected in a dose-dependent reduction in very-low-density lipoprotein (VLDL)-TG (R² = 0.20, p = 0.003). A weak dose-dependent shift in HDL (but not LDL) particle size was identified (R² = 0.05, p = 0.04). The results of this study indicate that DHA-rich n-3 LCPUFA supplementation at a dose of 1 g/day is an effective TG-lowering agent and increases HDL particle size in pre-menopausal women.

Authors+Show Affiliations

School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia. sparkesc@gmail.com. Illawarra Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia. sparkesc@gmail.com.University of Adelaide, Adelaide, SA 5005, Australia. robert.gibson@adelaide.edu.au.Faculty of Health, Deakin University, Geelong, VIC 3220, Australia. Andrew.sinclair@deakin.edu.au. Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC 3168, Australia. Andrew.sinclair@deakin.edu.au.School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia. pelse@uow.edu.au. Illawarra Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia. pelse@uow.edu.au.School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia. bmeyer@uow.edu.au. Illawarra Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia. bmeyer@uow.edu.au.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

30297663

Citation

Sparkes, Cassandra, et al. "Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil On Plasma Lipids and Lipoproteins in Pre-Menopausal Women: a Dose⁻Response Randomized Placebo-Controlled Trial." Nutrients, vol. 10, no. 10, 2018.
Sparkes C, Gibson R, Sinclair A, et al. Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose⁻Response Randomized Placebo-Controlled Trial. Nutrients. 2018;10(10).
Sparkes, C., Gibson, R., Sinclair, A., Else, P. L., & Meyer, B. J. (2018). Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose⁻Response Randomized Placebo-Controlled Trial. Nutrients, 10(10), doi:10.3390/nu10101460.
Sparkes C, et al. Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil On Plasma Lipids and Lipoproteins in Pre-Menopausal Women: a Dose⁻Response Randomized Placebo-Controlled Trial. Nutrients. 2018 Oct 8;10(10) PubMed PMID: 30297663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Low Dose Docosahexaenoic Acid-Rich Fish Oil on Plasma Lipids and Lipoproteins in Pre-Menopausal Women: A Dose⁻Response Randomized Placebo-Controlled Trial. AU - Sparkes,Cassandra, AU - Gibson,Robert, AU - Sinclair,Andrew, AU - Else,Paul L, AU - Meyer,Barbara J, Y1 - 2018/10/08/ PY - 2018/08/27/received PY - 2018/09/14/revised PY - 2018/09/21/accepted PY - 2018/10/10/entrez PY - 2018/10/10/pubmed PY - 2019/1/3/medline KW - DHA KW - lipoproteins KW - plasma lipids KW - premenopausal women JF - Nutrients JO - Nutrients VL - 10 IS - 10 N2 - Omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation has been shown to improve plasma lipid profiles in men and post-menopausal women, however, data for pre-menopausal women are lacking. The benefits of intakes less than 1 g/day have not been well studied, and dose⁻response data is limited. The aim of this study was to determine the effect of low doses of docosahexaenoic acid (DHA)-rich tuna oil on plasma triglyceride (TG) lowering in pre-menopausal women, and investigate if low dose DHA-rich tuna oil supplementation would increase the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle sizes. A randomized, double-blind, placebo-controlled trial was conducted, in which 53 healthy pre-menopausal women with mildly elevated plasma TG levels consumed 0, 0.35, 0.7, or 1 g/day n-3 LCPUFA as HiDHA™ tuna oil or placebo (Sunola oil) capsules for 8 weeks. Supplementation with 1 g/day n-3 LCPUFA, but not lower doses, reduced plasma TG by 23% in pre-menopausal women. This was reflected in a dose-dependent reduction in very-low-density lipoprotein (VLDL)-TG (R² = 0.20, p = 0.003). A weak dose-dependent shift in HDL (but not LDL) particle size was identified (R² = 0.05, p = 0.04). The results of this study indicate that DHA-rich n-3 LCPUFA supplementation at a dose of 1 g/day is an effective TG-lowering agent and increases HDL particle size in pre-menopausal women. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30297663/Effect_of_Low_Dose_Docosahexaenoic_Acid_Rich_Fish_Oil_on_Plasma_Lipids_and_Lipoproteins_in_Pre_Menopausal_Women:_A_Dose⁻Response_Randomized_Placebo_Controlled_Trial_ L2 - http://www.mdpi.com/resolver?pii=nu10101460 DB - PRIME DP - Unbound Medicine ER -