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Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age.
Front Immunol. 2018; 9:2009.FI

Abstract

Background:

Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana.

Objectives:

The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry.

Methods:

A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers.

Results:

CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson. Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings.

Authors+Show Affiliations

Department of Neurosciences and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. National Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, Brazil.National Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, Brazil. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.National Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, Brazil. Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.Department of Neurosciences and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. National Institute for Translational Medicine (INCT-TM; CNPq), São Paulo, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

30298064

Citation

Crippa, José A., et al. "Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age." Frontiers in Immunology, vol. 9, 2018, p. 2009.
Crippa JA, Guimarães FS, Campos AC, et al. Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Front Immunol. 2018;9:2009.
Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in Immunology, 9, 2009. https://doi.org/10.3389/fimmu.2018.02009
Crippa JA, et al. Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Front Immunol. 2018;9:2009. PubMed PMID: 30298064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. AU - Crippa,José A, AU - Guimarães,Francisco S, AU - Campos,Alline C, AU - Zuardi,Antonio W, Y1 - 2018/09/21/ PY - 2017/10/09/received PY - 2018/08/14/accepted PY - 2018/10/10/entrez PY - 2018/10/10/pubmed PY - 2019/10/1/medline KW - CBD KW - Cannabis sativa KW - antiepileptic KW - anxiolytic KW - cannabidiol KW - neuroprotection SP - 2009 EP - 2009 JF - Frontiers in immunology JO - Front Immunol VL - 9 N2 - Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a compound that does not produce the typical subjective effects of marijuana. Objectives: The aim of the present review is to describe the main advances in the development of the experimental and clinical use of cannabidiol CBD in neuropsychiatry. Methods: A non-systematic search was performed for studies dealing with therapeutic applications of CBD, especially performed by Brazilian researchers. Results: CBD was shown to have anxiolytic, antipsychotic and neuroprotective properties. In addition, basic and clinical investigations on the effects of CBD have been carried out in the context of many other health conditions, including its potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders, and Parkinson. Discussion: CBD is an useful and promising molecule that may help patients with a number of clinical conditions. Controlled clinical trials with different neuropsychiatric populations that are currently under investigation should bring important answers in the near future and support the translation of research findings to clinical settings. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/30298064/Translational_Investigation_of_the_Therapeutic_Potential_of_Cannabidiol__CBD_:_Toward_a_New_Age_ L2 - https://doi.org/10.3389/fimmu.2018.02009 DB - PRIME DP - Unbound Medicine ER -