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Prognostic role of baseline 18 F-FDG PET/CT parameters in MALT lymphoma.
Hematol Oncol. 2019 Feb; 37(1):39-46.HO

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent lymphoma with good prognosis and variable fluorine-18 fluorodeoxyglucose (18 F-FDG) avidity. Many possible prognostic factors have been investigated with controversial results, but the possible prognostic role of 18 F-FDG positron emission tomography/computed tomography (PET/CT) remains unclear. Our aim was to evaluate the prognostic impact of qualitative and semiquantitative baseline PET/CT parameters on outcome of MALT lymphoma. We retrospectively enrolled 161 patients with histologically confirmed MALT lymphoma who underwent 18 F-FDG PET/CT before any treatment. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). The Kaplan-Meier method was used to estimate the progression-free survival (PFS) and overall survival (OS) times. Cox regression models were performed to determine the relation between PET/CT features and OS and PFS. Ninety-eight patients had positive 18 F-FDG PET/CT showing 18 F-FDG uptake (mean SUVbw, 10.1; SUVlbm, 7.2; SUVbsa, 2.7; MTV, 88.8; and TLG, 526); the remaining 63 were not 18 F-FDG avid. 18 F-FDG avidity was significantly correlated with tumor size and Ki-67 score. Relapse/progression of disease occurred in 47 patients with an average time of 40.2 months; death occurred in 12 patients with an average of 59 months. At a median follow-up of 62 months, median PFS and OS were 52 and 62 months, respectively. Advanced tumor stage and extragastric site were demonstrated to be independent prognostic factors for PFS, while only tumor stage for OS. Instead, PET/CT parameters were not related to survival, despite positive correlation at univariate analysis between MTV and TLG with PFS and positive PET/CT with PFS and OS. In conclusion, a 61% rate of PET avidity in biopsy-confirmed MALT lymphoma was found, and it was correlated with tumor size and Ki-67 score. Only tumor stage and localization were independently correlated with PFS and OS.

Authors+Show Affiliations

Department of Nuclear Medicine, Spedali Civili di Brescia, Brescia, Italy.Department of Nuclear Medicine, Spedali Civili di Brescia, Brescia, Italy.Department of Nuclear Medicine, Spedali Civili di Brescia, Brescia, Italy.Division of Hematology, Spedali Civili di Brescia, Brescia, Italy.Division of Hematology, Spedali Civili di Brescia, Brescia, Italy.Division of Hematology, Spedali Civili di Brescia, Brescia, Italy.Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy.Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, Brescia, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30299563

Citation

Albano, Domenico, et al. "Prognostic Role of Baseline 18 F-FDG PET/CT Parameters in MALT Lymphoma." Hematological Oncology, vol. 37, no. 1, 2019, pp. 39-46.
Albano D, Bosio G, Camoni L, et al. Prognostic role of baseline 18 F-FDG PET/CT parameters in MALT lymphoma. Hematol Oncol. 2019;37(1):39-46.
Albano, D., Bosio, G., Camoni, L., Farina, M., Re, A., Tucci, A., Giubbini, R., & Bertagna, F. (2019). Prognostic role of baseline 18 F-FDG PET/CT parameters in MALT lymphoma. Hematological Oncology, 37(1), 39-46. https://doi.org/10.1002/hon.2563
Albano D, et al. Prognostic Role of Baseline 18 F-FDG PET/CT Parameters in MALT Lymphoma. Hematol Oncol. 2019;37(1):39-46. PubMed PMID: 30299563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic role of baseline 18 F-FDG PET/CT parameters in MALT lymphoma. AU - Albano,Domenico, AU - Bosio,Giovanni, AU - Camoni,Luca, AU - Farina,Mirko, AU - Re,Alessandro, AU - Tucci,Alessandra, AU - Giubbini,Raffaele, AU - Bertagna,Francesco, Y1 - 2018/11/08/ PY - 2018/08/07/received PY - 2018/09/24/revised PY - 2018/09/28/accepted PY - 2018/10/10/pubmed PY - 2019/3/6/medline PY - 2018/10/10/entrez KW - 18F-FDG PET/CT KW - MALT lymphoma KW - MTV KW - TLG KW - prognosis SP - 39 EP - 46 JF - Hematological oncology JO - Hematol Oncol VL - 37 IS - 1 N2 - Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent lymphoma with good prognosis and variable fluorine-18 fluorodeoxyglucose (18 F-FDG) avidity. Many possible prognostic factors have been investigated with controversial results, but the possible prognostic role of 18 F-FDG positron emission tomography/computed tomography (PET/CT) remains unclear. Our aim was to evaluate the prognostic impact of qualitative and semiquantitative baseline PET/CT parameters on outcome of MALT lymphoma. We retrospectively enrolled 161 patients with histologically confirmed MALT lymphoma who underwent 18 F-FDG PET/CT before any treatment. PET images were qualitatively and semiquantitatively analyzed by measuring the maximum standardized uptake value body weight (SUVbw), lean body mass (SUVlbm), body surface area (SUVbsa), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). The Kaplan-Meier method was used to estimate the progression-free survival (PFS) and overall survival (OS) times. Cox regression models were performed to determine the relation between PET/CT features and OS and PFS. Ninety-eight patients had positive 18 F-FDG PET/CT showing 18 F-FDG uptake (mean SUVbw, 10.1; SUVlbm, 7.2; SUVbsa, 2.7; MTV, 88.8; and TLG, 526); the remaining 63 were not 18 F-FDG avid. 18 F-FDG avidity was significantly correlated with tumor size and Ki-67 score. Relapse/progression of disease occurred in 47 patients with an average time of 40.2 months; death occurred in 12 patients with an average of 59 months. At a median follow-up of 62 months, median PFS and OS were 52 and 62 months, respectively. Advanced tumor stage and extragastric site were demonstrated to be independent prognostic factors for PFS, while only tumor stage for OS. Instead, PET/CT parameters were not related to survival, despite positive correlation at univariate analysis between MTV and TLG with PFS and positive PET/CT with PFS and OS. In conclusion, a 61% rate of PET avidity in biopsy-confirmed MALT lymphoma was found, and it was correlated with tumor size and Ki-67 score. Only tumor stage and localization were independently correlated with PFS and OS. SN - 1099-1069 UR - https://www.unboundmedicine.com/medline/citation/30299563/Prognostic_role_of_baseline_18_F_FDG_PET/CT_parameters_in_MALT_lymphoma_ L2 - https://doi.org/10.1002/hon.2563 DB - PRIME DP - Unbound Medicine ER -