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Impact of rotavirus vaccine introduction and genotypic characteristics of rotavirus strains in children less than 5 years of age with gastroenteritis in Ethiopia: 2011-2016.
Vaccine. 2018 11 12; 36(46):7043-7047.V

Abstract

INTRODUCTION

A monovalent rotavirus vaccine was introduced in the Ethiopian Expanded Program on Immunization from November 2013. We compared impact of rotavirus vaccine introduction on rotavirus associated acute diarrhea hospitalizations and genotypic characteristics of rotavirus strains pre-and post-vaccine introduction.

METHODS

Sentinel surveillance for diarrhea among children <5 years of age was conducted at 3 hospitals in Addis Ababa, Ethiopia from 2011 to 2017. Stool specimens were collected from enrolled children and tested using an antigen capture enzyme immunoassay. Rotavirus positive samples (156 from pre- and 141 from post-vaccination periods) were further characterized by rotavirus genotyping methods to identify the predominant G and P types circulating during the surveillance era.

RESULTS

A total of 788 children were enrolled during the pre- (July 2011-June 2013) and 815 children during the post-vaccination (July 2014-June 2017) periods. The proportion of diarrhea hospitalizations due to rotavirus among children <5 years of age declined by 17% from 24% (188/788) in the pre-vaccine period and to 20% (161/185) in post-vaccine introduction era. Similarly, a reduction of 18% in proportion of diarrhea hospitalizations due to rotavirus in children <12 months of age in the post (27%) vs pre-vaccine (33%) periods was observed. Seasonal peaks of rotavirus declined following rotavirus vaccine introduction. The most prevalent circulating strains were G12P[8] in 2011 (36%) and in 2012 (27%), G2P[4] (35%) in 2013, G9P[8] (19%) in 2014, G3P[6] and G2P[4] (19% each) in 2015, and G3P[8] (29%) in 2016.

DISCUSSION

Following rotavirus vaccine introduction in Ethiopia, a reduction in rotavirus associated hospitalizations was seen in all age groups with the greatest burden in children <12 months of age. A wide variety of rotavirus strains circulated in the pre- and post-vaccine introduction periods.

Authors+Show Affiliations

Ethiopian Public Health Institute, Addis Ababa, Ethiopia. Electronic address: almaz_abe1@yahoo.com.Ethiopian Public Health Institute, Addis Ababa, Ethiopia.SAMRC Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, South Africa.Ethiopian Public Health Institute, Addis Ababa, Ethiopia.Ethiopian Public Health Institute, Addis Ababa, Ethiopia.Ethiopian Public Health Institute, Addis Ababa, Ethiopia.Ethiopian Public Health Institute, Addis Ababa, Ethiopia.BeteZata Hospital, Addis Ababa, Ethiopia.Black Lion Hospital, AAU Medical Faculty, Addis Ababa, Ethiopia.Yekatit 12 Hospital, AAU Medical Faculty, Addis Ababa, Ethiopia.SAMRC Diarrhoeal Pathogens Research Unit, Department of Virology, Sefako Makgatho Health Sciences University, Medunsa, Pretoria, South Africa.WHO Country Office, Addis Ababa, Ethiopia.WHO Country Office, Addis Ababa, Ethiopia.Yekatit 12 Hospital, AAU Medical Faculty, Addis Ababa, Ethiopia.WHO Regional Office for Africa (WHO/AFRO), Harare, Zimbabwe.WHO Regional Office for Africa (WHO/AFRO), Brazzaville, People's Republic of Congo.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30301641

Citation

Abebe, Almaz, et al. "Impact of Rotavirus Vaccine Introduction and Genotypic Characteristics of Rotavirus Strains in Children Less Than 5 Years of Age With Gastroenteritis in Ethiopia: 2011-2016." Vaccine, vol. 36, no. 46, 2018, pp. 7043-7047.
Abebe A, Getahun M, Mapaseka SL, et al. Impact of rotavirus vaccine introduction and genotypic characteristics of rotavirus strains in children less than 5 years of age with gastroenteritis in Ethiopia: 2011-2016. Vaccine. 2018;36(46):7043-7047.
Abebe, A., Getahun, M., Mapaseka, S. L., Beyene, B., Assefa, E., Teshome, B., Tefera, M., Kebede, F., Habtamu, A., Haile-Mariam, T., Jeffrey Mphahlele, M., Teshager, F., Ademe, A., Teka, T., Weldegebriel, G. G., & Mwenda, J. M. (2018). Impact of rotavirus vaccine introduction and genotypic characteristics of rotavirus strains in children less than 5 years of age with gastroenteritis in Ethiopia: 2011-2016. Vaccine, 36(46), 7043-7047. https://doi.org/10.1016/j.vaccine.2018.09.048
Abebe A, et al. Impact of Rotavirus Vaccine Introduction and Genotypic Characteristics of Rotavirus Strains in Children Less Than 5 Years of Age With Gastroenteritis in Ethiopia: 2011-2016. Vaccine. 2018 11 12;36(46):7043-7047. PubMed PMID: 30301641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of rotavirus vaccine introduction and genotypic characteristics of rotavirus strains in children less than 5 years of age with gastroenteritis in Ethiopia: 2011-2016. AU - Abebe,Almaz, AU - Getahun,Mekonen, AU - Mapaseka,Seheri L, AU - Beyene,Berhane, AU - Assefa,Essete, AU - Teshome,Birke, AU - Tefera,Mesfin, AU - Kebede,Ferehiwot, AU - Habtamu,Abebe, AU - Haile-Mariam,Tewodros, AU - Jeffrey Mphahlele,M, AU - Teshager,Fasil, AU - Ademe,Ayesheshem, AU - Teka,Telahun, AU - Weldegebriel,Goitom G, AU - Mwenda,Jason M, Y1 - 2018/10/06/ PY - 2018/05/25/received PY - 2018/09/05/revised PY - 2018/09/21/accepted PY - 2018/10/12/pubmed PY - 2019/1/22/medline PY - 2018/10/11/entrez KW - Ethiopian children KW - Impact KW - Monovalent rotavirus vaccine KW - Rotavirus SP - 7043 EP - 7047 JF - Vaccine JO - Vaccine VL - 36 IS - 46 N2 - INTRODUCTION: A monovalent rotavirus vaccine was introduced in the Ethiopian Expanded Program on Immunization from November 2013. We compared impact of rotavirus vaccine introduction on rotavirus associated acute diarrhea hospitalizations and genotypic characteristics of rotavirus strains pre-and post-vaccine introduction. METHODS: Sentinel surveillance for diarrhea among children <5 years of age was conducted at 3 hospitals in Addis Ababa, Ethiopia from 2011 to 2017. Stool specimens were collected from enrolled children and tested using an antigen capture enzyme immunoassay. Rotavirus positive samples (156 from pre- and 141 from post-vaccination periods) were further characterized by rotavirus genotyping methods to identify the predominant G and P types circulating during the surveillance era. RESULTS: A total of 788 children were enrolled during the pre- (July 2011-June 2013) and 815 children during the post-vaccination (July 2014-June 2017) periods. The proportion of diarrhea hospitalizations due to rotavirus among children <5 years of age declined by 17% from 24% (188/788) in the pre-vaccine period and to 20% (161/185) in post-vaccine introduction era. Similarly, a reduction of 18% in proportion of diarrhea hospitalizations due to rotavirus in children <12 months of age in the post (27%) vs pre-vaccine (33%) periods was observed. Seasonal peaks of rotavirus declined following rotavirus vaccine introduction. The most prevalent circulating strains were G12P[8] in 2011 (36%) and in 2012 (27%), G2P[4] (35%) in 2013, G9P[8] (19%) in 2014, G3P[6] and G2P[4] (19% each) in 2015, and G3P[8] (29%) in 2016. DISCUSSION: Following rotavirus vaccine introduction in Ethiopia, a reduction in rotavirus associated hospitalizations was seen in all age groups with the greatest burden in children <12 months of age. A wide variety of rotavirus strains circulated in the pre- and post-vaccine introduction periods. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/30301641/Impact_of_rotavirus_vaccine_introduction_and_genotypic_characteristics_of_rotavirus_strains_in_children_less_than_5_years_of_age_with_gastroenteritis_in_Ethiopia:_2011_2016_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(18)31317-3 DB - PRIME DP - Unbound Medicine ER -