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The effectiveness of bronchoscopy in the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in acquired immunodeficiency syndrome.
Arch Pathol Lab Med. 1987 Mar; 111(3):238-41.AP

Abstract

We evaluated the sensitivity of bronchoscopy for the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in patients with acquired immunodeficiency syndrome. The antemortem and postmortem diagnoses were compared in 36 patients who underwent fiberoptic bronchoscopy within two weeks of death. In autopsy-proved cases of Pneumocystis carinii pneumonia (PCP), the organism was correctly identified antemortem in 22 (88%) of 25 cases, including 94% of adequate transbronchial bronchoscopic biopsy specimens, 95% and 88% of bronchoalveolar lavage (BAL) cell blocks and smears, respectively, and 79% of brushing. In 11 patients who underwent simultaneous adequate biopsy, BAL, and brushings, the diagnostic sensitivity for PCP was 100%. The negative predictive value of bronchoscopy for PCP was 85%. Bronchoscopy yielded the diagnosis of cytomegalovirus infection in only 55% of autopsy-proved cases. Diagnostic sensitivity was also reduced when an important diagnostic procedure, such as transbronchial biopsy or BAL, was inadequate or not performed.

Authors

Gal AA
No affiliation info available
Klatt EC
No affiliation info available
Koss MN
No affiliation info available
Strigle SM
No affiliation info available
Boylen CT
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultBronchoscopyCytomegalovirus InfectionsFemaleHumansLungMaleMiddle AgedPneumonia, PneumocystisPneumonia, Viral

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3030223

Citation

Gal, A A., et al. "The Effectiveness of Bronchoscopy in the Diagnosis of Pneumocystis Carinii and Cytomegalovirus Pulmonary Infections in Acquired Immunodeficiency Syndrome." Archives of Pathology & Laboratory Medicine, vol. 111, no. 3, 1987, pp. 238-41.
Gal AA, Klatt EC, Koss MN, et al. The effectiveness of bronchoscopy in the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1987;111(3):238-41.
Gal, A. A., Klatt, E. C., Koss, M. N., Strigle, S. M., & Boylen, C. T. (1987). The effectiveness of bronchoscopy in the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in acquired immunodeficiency syndrome. Archives of Pathology & Laboratory Medicine, 111(3), 238-41.
Gal AA, et al. The Effectiveness of Bronchoscopy in the Diagnosis of Pneumocystis Carinii and Cytomegalovirus Pulmonary Infections in Acquired Immunodeficiency Syndrome. Arch Pathol Lab Med. 1987;111(3):238-41. PubMed PMID: 3030223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effectiveness of bronchoscopy in the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in acquired immunodeficiency syndrome. AU - Gal,A A, AU - Klatt,E C, AU - Koss,M N, AU - Strigle,S M, AU - Boylen,C T, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 238 EP - 41 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 111 IS - 3 N2 - We evaluated the sensitivity of bronchoscopy for the diagnosis of Pneumocystis carinii and cytomegalovirus pulmonary infections in patients with acquired immunodeficiency syndrome. The antemortem and postmortem diagnoses were compared in 36 patients who underwent fiberoptic bronchoscopy within two weeks of death. In autopsy-proved cases of Pneumocystis carinii pneumonia (PCP), the organism was correctly identified antemortem in 22 (88%) of 25 cases, including 94% of adequate transbronchial bronchoscopic biopsy specimens, 95% and 88% of bronchoalveolar lavage (BAL) cell blocks and smears, respectively, and 79% of brushing. In 11 patients who underwent simultaneous adequate biopsy, BAL, and brushings, the diagnostic sensitivity for PCP was 100%. The negative predictive value of bronchoscopy for PCP was 85%. Bronchoscopy yielded the diagnosis of cytomegalovirus infection in only 55% of autopsy-proved cases. Diagnostic sensitivity was also reduced when an important diagnostic procedure, such as transbronchial biopsy or BAL, was inadequate or not performed. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/3030223/The_effectiveness_of_bronchoscopy_in_the_diagnosis_of_Pneumocystis_carinii_and_cytomegalovirus_pulmonary_infections_in_acquired_immunodeficiency_syndrome_ DB - PRIME DP - Unbound Medicine ER -