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The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma.
Obstet Gynecol. 2018 11; 132(5):1116-1119.OG

Abstract

BACKGROUND

The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses.

CASE

A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium.

CONCLUSION

The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

West L
Departments of Dermatology and Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, and the Department of Dermatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Carlson M
No affiliation info available
Wallis L
No affiliation info available
Goff HW
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaAgedEndometrial NeoplasmsFallopian Tube NeoplasmsFemaleHumansKeratosis, SeborrheicNeoplasms, Cystic, Mucinous, and SerousNeoplasms, Multiple PrimaryParaneoplastic Syndromes

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30303917

Citation

West, Lindsey, et al. "The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma." Obstetrics and Gynecology, vol. 132, no. 5, 2018, pp. 1116-1119.
West L, Carlson M, Wallis L, et al. The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma. Obstet Gynecol. 2018;132(5):1116-1119.
West, L., Carlson, M., Wallis, L., & Goff, H. W. (2018). The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma. Obstetrics and Gynecology, 132(5), 1116-1119. https://doi.org/10.1097/AOG.0000000000002920
West L, et al. The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma. Obstet Gynecol. 2018;132(5):1116-1119. PubMed PMID: 30303917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma. AU - West,Lindsey, AU - Carlson,Matthew, AU - Wallis,Luke, AU - Goff,Heather W, PY - 2018/10/12/pubmed PY - 2019/9/26/medline PY - 2018/10/11/entrez SP - 1116 EP - 1119 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 132 IS - 5 N2 - BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy. SN - 1873-233X UR - https://www.unboundmedicine.com/medline/citation/30303917/The_Sign_of_Leser_Trel��t_and_Malignant_Acanthosis_Nigricans_Associated_With_Fallopian_Tube_Carcinoma_ DB - PRIME DP - Unbound Medicine ER -