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Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats.
Pharmacology. 2018; 102(5-6):332-338.P

Abstract

This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Paw withdrawal thresholds (PWT) were mechanically assessed using von Frey filaments. The involvement of 5-HT and α2-adrenergic receptors in antiallodynia was determined using antagonists with the following receptor specificities: nonselective 5-HT (dihydroergocristine), 5-HT7 (SB269970), nonselective α2-adrenoceptor (yohimbine), α-2A (BRL 44408), α-2B (ARC 239), and α-2C (JP 1302). Intrathecal areca nut significantly increased the PWT in both spinal nerve-ligated and chemotherapy-induced NP (‡ p < 0.001). Intrathecal dihydroergocristine, SB269970, yohimbine, BRL 44408, ARC 239, and JP 1302 significantly reversed the antiallodynic effects of areca nut in both NP states (‡ p < 0.001). Collectively, intrathecal areca nut suppressed mechanical allodynia induced by spinal nerve ligation and cisplatin injection. Furthermore, spinal 5-HT7 receptor and α2A, α2B, and α2C-adrenoceptors contributed to the antiallodynic effects of areca nut.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.Korean Medicinal Herbs Research Team, National Development Institute of Korea Medicine, Jangheung, Republic of Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Republic of Koreamhyoon@jnu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30304725

Citation

Lee, Hyung Gon, et al. "Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats." Pharmacology, vol. 102, no. 5-6, 2018, pp. 332-338.
Lee HG, Song JA, Han DS, et al. Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats. Pharmacology. 2018;102(5-6):332-338.
Lee, H. G., Song, J. A., Han, D. S., Woo, K. W., & Yoon, M. H. (2018). Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats. Pharmacology, 102(5-6), 332-338. https://doi.org/10.1159/000492394
Lee HG, et al. Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats. Pharmacology. 2018;102(5-6):332-338. PubMed PMID: 30304725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallodynic Effects of Intrathecal Areca Nut for Spinal Nerve-Ligated and Chemotherapy-Induced Neuropathic Pain in Rats. AU - Lee,Hyung Gon, AU - Song,Ji A, AU - Han,Dong Soo, AU - Woo,Kyeong Wan, AU - Yoon,Myung Ha, Y1 - 2018/10/10/ PY - 2018/01/25/received PY - 2018/07/24/accepted PY - 2018/10/12/pubmed PY - 2018/12/20/medline PY - 2018/10/11/entrez KW - 5-hydroxytryptamine receptors KW - Antiallodynia KW - Areca nut KW - Neuropathic pain KW - Spinal cord KW - α2-adrenoceptors SP - 332 EP - 338 JF - Pharmacology JO - Pharmacology VL - 102 IS - 5-6 N2 - This study examined the effects of intrathecal areca nut on spinal nerve-ligated and chemotherapy-induced neuropathic pain (NP), and investigated the relevance of spinal 5-hydroxytryptamine (5-HT) and α2-adrenergic receptors to those effects. For drug administration, intrathecal catheters were inserted into the subarachnoid space of male Sprague-Dawley rats. NP was induced either by spinal nerve ligation (left spinal nerves L5 and L6) or by chemotherapeutic injection (intraperitoneal cisplatin, 2 mg/kg/day, once daily for 4 days). Paw withdrawal thresholds (PWT) were mechanically assessed using von Frey filaments. The involvement of 5-HT and α2-adrenergic receptors in antiallodynia was determined using antagonists with the following receptor specificities: nonselective 5-HT (dihydroergocristine), 5-HT7 (SB269970), nonselective α2-adrenoceptor (yohimbine), α-2A (BRL 44408), α-2B (ARC 239), and α-2C (JP 1302). Intrathecal areca nut significantly increased the PWT in both spinal nerve-ligated and chemotherapy-induced NP (‡ p < 0.001). Intrathecal dihydroergocristine, SB269970, yohimbine, BRL 44408, ARC 239, and JP 1302 significantly reversed the antiallodynic effects of areca nut in both NP states (‡ p < 0.001). Collectively, intrathecal areca nut suppressed mechanical allodynia induced by spinal nerve ligation and cisplatin injection. Furthermore, spinal 5-HT7 receptor and α2A, α2B, and α2C-adrenoceptors contributed to the antiallodynic effects of areca nut. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/30304725/Antiallodynic_Effects_of_Intrathecal_Areca_Nut_for_Spinal_Nerve_Ligated_and_Chemotherapy_Induced_Neuropathic_Pain_in_Rats_ L2 - https://www.karger.com?DOI=10.1159/000492394 DB - PRIME DP - Unbound Medicine ER -