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Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat.
Br J Pharmacol. 1987 Feb; 90(2):431-9.BJ

Abstract

The pressor and vascular permeability effects of leukotrienes B4 (LTB4), C4 and D4 were investigated in conscious unrestrained rats. Leukotrienes C4 and D4 (3.2-51 nmol kg-1 i.v.) caused an acute dose-dependent elevation of the mean arterial pressure, which was maximal after 2 min and returned to control levels within 14 min. Heart rate was significantly reduced by the higher doses of LTC4 and LTD4. LTB4 (up to a dose of 51 nmol kg-1) was essentially inactive. These effects of LTC4 and LTD4 were abolished by FPL 55712, a putative antagonist of sulphidopeptide leukotrienes and by verapamil, a calcium channel blocker. Indomethacin, phentolamine or saralasin pretreatment failed to modify the pressor response to LTC4 and LTD4. LTC4 and LTD4 furthermore caused an increase in haematocrit values, which was significantly attenuated by FPL 55712, indomethacin and verapamil. The present findings show that the pressor effect of LTC4 and LTD4 is not related to prostanoid release and can be reversed by calcium channel blockade; whereas the effect on vascular permeability seems to require the presence of both cyclo-oxygenase product(s) and calcium.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3030486

Citation

Filep, J, et al. "Vascular Responses to Leukotriene B4, C4 and D4 Following FPL 55712, Indomethacin, Saralasin, Phentolamine and Verapamil in the Conscious Rat." British Journal of Pharmacology, vol. 90, no. 2, 1987, pp. 431-9.
Filep J, Földes-Filep E, Frölich JC. Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat. Br J Pharmacol. 1987;90(2):431-9.
Filep, J., Földes-Filep, E., & Frölich, J. C. (1987). Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat. British Journal of Pharmacology, 90(2), 431-9.
Filep J, Földes-Filep E, Frölich JC. Vascular Responses to Leukotriene B4, C4 and D4 Following FPL 55712, Indomethacin, Saralasin, Phentolamine and Verapamil in the Conscious Rat. Br J Pharmacol. 1987;90(2):431-9. PubMed PMID: 3030486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat. AU - Filep,J, AU - Földes-Filep,E, AU - Frölich,J C, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 431 EP - 9 JF - British journal of pharmacology JO - Br J Pharmacol VL - 90 IS - 2 N2 - The pressor and vascular permeability effects of leukotrienes B4 (LTB4), C4 and D4 were investigated in conscious unrestrained rats. Leukotrienes C4 and D4 (3.2-51 nmol kg-1 i.v.) caused an acute dose-dependent elevation of the mean arterial pressure, which was maximal after 2 min and returned to control levels within 14 min. Heart rate was significantly reduced by the higher doses of LTC4 and LTD4. LTB4 (up to a dose of 51 nmol kg-1) was essentially inactive. These effects of LTC4 and LTD4 were abolished by FPL 55712, a putative antagonist of sulphidopeptide leukotrienes and by verapamil, a calcium channel blocker. Indomethacin, phentolamine or saralasin pretreatment failed to modify the pressor response to LTC4 and LTD4. LTC4 and LTD4 furthermore caused an increase in haematocrit values, which was significantly attenuated by FPL 55712, indomethacin and verapamil. The present findings show that the pressor effect of LTC4 and LTD4 is not related to prostanoid release and can be reversed by calcium channel blockade; whereas the effect on vascular permeability seems to require the presence of both cyclo-oxygenase product(s) and calcium. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/3030486/Vascular_responses_to_leukotriene_B4_C4_and_D4_following_FPL_55712_indomethacin_saralasin_phentolamine_and_verapamil_in_the_conscious_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1987&volume=90&issue=2&spage=431 DB - PRIME DP - Unbound Medicine ER -