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Anti-NMDAR encephalitis complicating pregnancy.
Pract Neurol. 2019 Apr; 19(2):131-135.PN

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was first reported in 2005 in four patients with ovarian teratomas; there have been many further cases reported since the antigen for the NMDAR antibody was confirmed in 2007. Patients characteristically have a well-defined set of features, characterised by psychiatric disturbance, seizures and cognitive disturbance, followed by movement disorders, disorders of consciousness and dysautonomia. To date, 14 cases of NMDAR encephalitis have been described in the context of pregnancy. We report a case of NMDAR encephalitis in a 34-year-old woman at 8 weeks' gestation. She had a turbulent clinical course and was initially admitted to a psychiatric unit. She was successfully treated with first-line immunomodulatory therapies and surgical resection of an ovarian teratoma. Following discharge she delivered a healthy baby and made a complete clinical recovery.

Authors+Show Affiliations

Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK.Department of Neurology, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK v.singh-curry@nhs.net.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

30305377

Citation

Kalam, Sabrina, et al. "Anti-NMDAR Encephalitis Complicating Pregnancy." Practical Neurology, vol. 19, no. 2, 2019, pp. 131-135.
Kalam S, Baheerathan A, McNamara C, et al. Anti-NMDAR encephalitis complicating pregnancy. Pract Neurol. 2019;19(2):131-135.
Kalam, S., Baheerathan, A., McNamara, C., & Singh-Curry, V. (2019). Anti-NMDAR encephalitis complicating pregnancy. Practical Neurology, 19(2), 131-135. https://doi.org/10.1136/practneurol-2018-002042
Kalam S, et al. Anti-NMDAR Encephalitis Complicating Pregnancy. Pract Neurol. 2019;19(2):131-135. PubMed PMID: 30305377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-NMDAR encephalitis complicating pregnancy. AU - Kalam,Sabrina, AU - Baheerathan,Aravindhan, AU - McNamara,Cillian, AU - Singh-Curry,Victoria, Y1 - 2018/10/10/ PY - 2018/09/09/accepted PY - 2018/10/12/pubmed PY - 2019/4/13/medline PY - 2018/10/12/entrez KW - NMDA KW - epilepsy KW - neuroimmunology KW - obstetrics KW - psychiatry SP - 131 EP - 135 JF - Practical neurology JO - Pract Neurol VL - 19 IS - 2 N2 - Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was first reported in 2005 in four patients with ovarian teratomas; there have been many further cases reported since the antigen for the NMDAR antibody was confirmed in 2007. Patients characteristically have a well-defined set of features, characterised by psychiatric disturbance, seizures and cognitive disturbance, followed by movement disorders, disorders of consciousness and dysautonomia. To date, 14 cases of NMDAR encephalitis have been described in the context of pregnancy. We report a case of NMDAR encephalitis in a 34-year-old woman at 8 weeks' gestation. She had a turbulent clinical course and was initially admitted to a psychiatric unit. She was successfully treated with first-line immunomodulatory therapies and surgical resection of an ovarian teratoma. Following discharge she delivered a healthy baby and made a complete clinical recovery. SN - 1474-7766 UR - https://www.unboundmedicine.com/medline/citation/30305377/Anti_NMDAR_encephalitis_complicating_pregnancy_ L2 - https://pn.bmj.com/lookup/pmidlookup?view=long&pmid=30305377 DB - PRIME DP - Unbound Medicine ER -