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Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women.
Osteoporos Int 2019; 30(2):411-421OI

Abstract

An exploratory study in elderly women and men from the Geneva Retirees Cohort indicates that low-frequency quantitative ultrasound measurement at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk.

INTRODUCTION:

The contribution of distal radius bone mineral density (BMD) and cortical microstructure to fracture risk has recently been demonstrated. In this exploratory study, we investigated whether low-frequency quantitative ultrasound measurement at the distal radius may capture the peripheral determinants of bone fragility assessed with dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT).

METHODS

Low-frequency velocity (VLF) was measured at the radius using OsCare Sono®, a portable axial transmission ultrasonometer, in 271 community-dwelling postmenopausal women and men (age 71.5 ± 1.4 years) from the Geneva Retirees Cohort. Cortical (Ct) and trabecular (Tb) volumetric (v) BMD and microstructure at the distal radius were assessed by HR-pQCT, in addition to areal (a) BMD by DXA, at the same time point.

RESULTS

VLF was highly correlated with aBMD at the distal third radius (r = 0.72, p < 0.001). For microstructure parameters, the highest correlation was observed with cortical area (r = 0.59, p < 0.001). VLF also captured bone geometry (total area) and cortical tissue mineral density independently of aBMD. In models adjusted for age and sex, VLF was significantly associated with prevalent low-trauma fractures [OR 95%CI for one SD decrease of VLF 1.50 (1.05, 2.14), p = 0.024], with discrimination performance comparable to femoral neck or distal radius aBMD.

CONCLUSION

Measurement of VLF at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk.

Authors+Show Affiliations

Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland. Emmanuel.Biver@hcuge.ch.Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland. Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Rome, Italy.Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland. Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30306224

Citation

Biver, E, et al. "Associations Between Radius Low-frequency Axial Ultrasound Velocity and Bone Fragility in Elderly Men and Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 30, no. 2, 2019, pp. 411-421.
Biver E, Pepe J, de Sire A, et al. Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women. Osteoporos Int. 2019;30(2):411-421.
Biver, E., Pepe, J., de Sire, A., Chevalley, T., & Ferrari, S. (2019). Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(2), pp. 411-421. doi:10.1007/s00198-018-4725-0.
Biver E, et al. Associations Between Radius Low-frequency Axial Ultrasound Velocity and Bone Fragility in Elderly Men and Women. Osteoporos Int. 2019;30(2):411-421. PubMed PMID: 30306224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between radius low-frequency axial ultrasound velocity and bone fragility in elderly men and women. AU - Biver,E, AU - Pepe,J, AU - de Sire,A, AU - Chevalley,T, AU - Ferrari,S, Y1 - 2018/10/10/ PY - 2018/02/20/received PY - 2018/09/27/accepted PY - 2018/10/12/pubmed PY - 2019/9/4/medline PY - 2018/10/12/entrez KW - Bone microstructure KW - Bone mineral density KW - Fracture KW - Osteoporosis KW - Ultrasonic low-frequency velocity SP - 411 EP - 421 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 30 IS - 2 N2 - : An exploratory study in elderly women and men from the Geneva Retirees Cohort indicates that low-frequency quantitative ultrasound measurement at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk. INTRODUCTION: The contribution of distal radius bone mineral density (BMD) and cortical microstructure to fracture risk has recently been demonstrated. In this exploratory study, we investigated whether low-frequency quantitative ultrasound measurement at the distal radius may capture the peripheral determinants of bone fragility assessed with dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT). METHODS: Low-frequency velocity (VLF) was measured at the radius using OsCare Sono®, a portable axial transmission ultrasonometer, in 271 community-dwelling postmenopausal women and men (age 71.5 ± 1.4 years) from the Geneva Retirees Cohort. Cortical (Ct) and trabecular (Tb) volumetric (v) BMD and microstructure at the distal radius were assessed by HR-pQCT, in addition to areal (a) BMD by DXA, at the same time point. RESULTS: VLF was highly correlated with aBMD at the distal third radius (r = 0.72, p < 0.001). For microstructure parameters, the highest correlation was observed with cortical area (r = 0.59, p < 0.001). VLF also captured bone geometry (total area) and cortical tissue mineral density independently of aBMD. In models adjusted for age and sex, VLF was significantly associated with prevalent low-trauma fractures [OR 95%CI for one SD decrease of VLF 1.50 (1.05, 2.14), p = 0.024], with discrimination performance comparable to femoral neck or distal radius aBMD. CONCLUSION: Measurement of VLF at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/30306224/Associations_between_radius_low_frequency_axial_ultrasound_velocity_and_bone_fragility_in_elderly_men_and_women_ L2 - https://dx.doi.org/10.1007/s00198-018-4725-0 DB - PRIME DP - Unbound Medicine ER -