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The impact of volume loading-induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats.
Physiol Rep. 2018 09; 6(19):e13887.PR

Abstract

Although low pressure baroreflex (LPB) has been shown to elicit various cardiovascular responses, its impact on sympathetic nerve activity (SNA) and arterial baroreflex (ABR) function has not been fully elucidated. The aim of this study was to clarify how volume loading-induced acute LPB activation impacts on SNA and ABR function in normal rats. In 20 anesthetized Sprague-Dawley rats, we isolated bilateral carotid sinuses, controlled carotid sinus pressure (CSP), and measured central venous pressure (CVP), splanchnic SNA, and arterial pressure (AP). We infused blood stepwise (3 mL/kg/step) to activate volume loading-induced LPB. Under the ABR open-loop condition, stepwise volume loading markedly increased SNA by 76.8 ± 21.6% at CVP of 3.6 ± 0.2 mmHg. In contrast, further volume loading suppressed SNA toward the baseline condition. Bilateral vagotomy totally abolished the changes in SNA by volume loading. To assess the impact of LPB on ABR function, we changed CSP stepwise. Low volume loading (CVP = 3.6 ± 0.4 mmHg) significantly shifted the sigmoidal CSP-SNA relationship (central arc) upward from baseline, whereas high volume loading (CVP = 5.4 ± 0.4 mmHg) returned it to the baseline level. Volume loading shifted the linear SNA-AP relationship (peripheral arc) upward without significant changes in slope. In conclusions, volume loading-induced acute LPB activation evoked two-phase changes, an initial increase followed by decline from baseline value, in SNA via resetting of the ABR central arc. LPB may contribute greatly to stabilize AP in response to volume status.

Authors+Show Affiliations

Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30307125

Citation

Oga, Yasuhiro, et al. "The Impact of Volume Loading-induced Low Pressure Baroreflex Activation On Arterial Baroreflex-controlled Sympathetic Arterial Pressure Regulation in Normal Rats." Physiological Reports, vol. 6, no. 19, 2018, pp. e13887.
Oga Y, Saku K, Nishikawa T, et al. The impact of volume loading-induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats. Physiol Rep. 2018;6(19):e13887.
Oga, Y., Saku, K., Nishikawa, T., Kishi, T., Tobushi, T., Hosokawa, K., Tohyama, T., Sakamoto, T., Sunagawa, K., & Tsutsui, H. (2018). The impact of volume loading-induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats. Physiological Reports, 6(19), e13887. https://doi.org/10.14814/phy2.13887
Oga Y, et al. The Impact of Volume Loading-induced Low Pressure Baroreflex Activation On Arterial Baroreflex-controlled Sympathetic Arterial Pressure Regulation in Normal Rats. Physiol Rep. 2018;6(19):e13887. PubMed PMID: 30307125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of volume loading-induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats. AU - Oga,Yasuhiro, AU - Saku,Keita, AU - Nishikawa,Takuya, AU - Kishi,Takuya, AU - Tobushi,Tomoyuki, AU - Hosokawa,Kazuya, AU - Tohyama,Takeshi, AU - Sakamoto,Takafumi, AU - Sunagawa,Kenji, AU - Tsutsui,Hiroyuki, PY - 2018/05/16/received PY - 2018/09/14/revised PY - 2018/09/19/accepted PY - 2018/10/12/entrez PY - 2018/10/12/pubmed PY - 2019/9/24/medline KW - Arterial baroreflex KW - circulatory homeostasis KW - low pressure baroreflex KW - sympathetic nerve activity SP - e13887 EP - e13887 JF - Physiological reports JO - Physiol Rep VL - 6 IS - 19 N2 - Although low pressure baroreflex (LPB) has been shown to elicit various cardiovascular responses, its impact on sympathetic nerve activity (SNA) and arterial baroreflex (ABR) function has not been fully elucidated. The aim of this study was to clarify how volume loading-induced acute LPB activation impacts on SNA and ABR function in normal rats. In 20 anesthetized Sprague-Dawley rats, we isolated bilateral carotid sinuses, controlled carotid sinus pressure (CSP), and measured central venous pressure (CVP), splanchnic SNA, and arterial pressure (AP). We infused blood stepwise (3 mL/kg/step) to activate volume loading-induced LPB. Under the ABR open-loop condition, stepwise volume loading markedly increased SNA by 76.8 ± 21.6% at CVP of 3.6 ± 0.2 mmHg. In contrast, further volume loading suppressed SNA toward the baseline condition. Bilateral vagotomy totally abolished the changes in SNA by volume loading. To assess the impact of LPB on ABR function, we changed CSP stepwise. Low volume loading (CVP = 3.6 ± 0.4 mmHg) significantly shifted the sigmoidal CSP-SNA relationship (central arc) upward from baseline, whereas high volume loading (CVP = 5.4 ± 0.4 mmHg) returned it to the baseline level. Volume loading shifted the linear SNA-AP relationship (peripheral arc) upward without significant changes in slope. In conclusions, volume loading-induced acute LPB activation evoked two-phase changes, an initial increase followed by decline from baseline value, in SNA via resetting of the ABR central arc. LPB may contribute greatly to stabilize AP in response to volume status. SN - 2051-817X UR - https://www.unboundmedicine.com/medline/citation/30307125/The_impact_of_volume_loading_induced_low_pressure_baroreflex_activation_on_arterial_baroreflex_controlled_sympathetic_arterial_pressure_regulation_in_normal_rats_ L2 - https://doi.org/10.14814/phy2.13887 DB - PRIME DP - Unbound Medicine ER -