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A Retrospective Review of Hospital-Based Data on Enteric Fever in India, 2014-2015.
J Infect Dis. 2018 11 10; 218(suppl_4):S206-S213.JI

Abstract

Background

Enteric fever remains a threat to many countries with minimal access to clean water and poor sanitation infrastructure. As part of a multisite surveillance study, we conducted a retrospective review of records in 5 hospitals across India to gather evidence on the burden of enteric fever.

Methods

We examined hospital records (laboratory and surgical registers) from 5 hospitals across India for laboratory-confirmed Salmonella Typhi or Salmonella Paratyphi cases and intestinal perforations from 2014-2015. Clinical data were obtained where available. For laboratory-confirmed infections, we compared differences in disease burden, age, sex, clinical presentation, and antimicrobial resistance.

Results

Of 267536 blood cultures, 1418 (0.53%) were positive for S. Typhi or S. Paratyphi. Clinical data were available for 429 cases (72%); a higher proportion of participants with S. Typhi infection were hospitalized, compared with those with S. Paratyphi infection (44% vs 35%). We observed resistance to quinolones among 82% of isolates, with cases of cephalosporin resistance (1%) and macrolide resistance (9%) detected. Of 94 participants with intestinal perforations, 16 (17%) had a provisional, final, or laboratory-confirmed diagnosis of enteric fever.

Discussion

Data show a moderate burden of enteric fever in India. Enteric fever data should be systematically collected to facilitate evidence-based decision-making by countries for typhoid conjugate vaccines.

Authors+Show Affiliations

Translational Health Science and Technology Institute, Faridabad, India.Sabin Vaccine Institute, Washington, D. C., Georgia.Translational Health Science and Technology Institute, Faridabad, India.Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia.Translational Health Science and Technology Institute, Faridabad, India.Sabin Vaccine Institute, Washington, D. C., Georgia.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30307566

Citation

Sur, Dipika, et al. "A Retrospective Review of Hospital-Based Data On Enteric Fever in India, 2014-2015." The Journal of Infectious Diseases, vol. 218, no. suppl_4, 2018, pp. S206-S213.
Sur D, Barkume C, Mukhopadhyay B, et al. A Retrospective Review of Hospital-Based Data on Enteric Fever in India, 2014-2015. J Infect Dis. 2018;218(suppl_4):S206-S213.
Sur, D., Barkume, C., Mukhopadhyay, B., Date, K., Ganguly, N. K., & Garrett, D. (2018). A Retrospective Review of Hospital-Based Data on Enteric Fever in India, 2014-2015. The Journal of Infectious Diseases, 218(suppl_4), S206-S213. https://doi.org/10.1093/infdis/jiy502
Sur D, et al. A Retrospective Review of Hospital-Based Data On Enteric Fever in India, 2014-2015. J Infect Dis. 2018 11 10;218(suppl_4):S206-S213. PubMed PMID: 30307566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Retrospective Review of Hospital-Based Data on Enteric Fever in India, 2014-2015. AU - Sur,Dipika, AU - Barkume,Caitlin, AU - Mukhopadhyay,Bratati, AU - Date,Kashmira, AU - Ganguly,Nirmal Kumar, AU - Garrett,Denise, PY - 2018/04/30/received PY - 2018/08/21/accepted PY - 2018/10/12/pubmed PY - 2019/9/20/medline PY - 2018/10/12/entrez SP - S206 EP - S213 JF - The Journal of infectious diseases JO - J Infect Dis VL - 218 IS - suppl_4 N2 - Background: Enteric fever remains a threat to many countries with minimal access to clean water and poor sanitation infrastructure. As part of a multisite surveillance study, we conducted a retrospective review of records in 5 hospitals across India to gather evidence on the burden of enteric fever. Methods: We examined hospital records (laboratory and surgical registers) from 5 hospitals across India for laboratory-confirmed Salmonella Typhi or Salmonella Paratyphi cases and intestinal perforations from 2014-2015. Clinical data were obtained where available. For laboratory-confirmed infections, we compared differences in disease burden, age, sex, clinical presentation, and antimicrobial resistance. Results: Of 267536 blood cultures, 1418 (0.53%) were positive for S. Typhi or S. Paratyphi. Clinical data were available for 429 cases (72%); a higher proportion of participants with S. Typhi infection were hospitalized, compared with those with S. Paratyphi infection (44% vs 35%). We observed resistance to quinolones among 82% of isolates, with cases of cephalosporin resistance (1%) and macrolide resistance (9%) detected. Of 94 participants with intestinal perforations, 16 (17%) had a provisional, final, or laboratory-confirmed diagnosis of enteric fever. Discussion: Data show a moderate burden of enteric fever in India. Enteric fever data should be systematically collected to facilitate evidence-based decision-making by countries for typhoid conjugate vaccines. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/30307566/A_Retrospective_Review_of_Hospital_Based_Data_on_Enteric_Fever_in_India_2014_2015_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiy502 DB - PRIME DP - Unbound Medicine ER -