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Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress-related damage in an experimental model of ethanol-induced hepatotoxicity.
Appl Physiol Nutr Metab 2019; 44(5):521-527AP

Abstract

Ethanol is the most widely abused drug in the world and its long-term use induces oxidative stress in the liver tissue. The aim of this study was to evaluate protective effect of Viola odorata against ethanol-induced hepatotoxicity in Wistar rat. Animals were divided into 9 groups as follows: control (normal saline), ethanol (10 mg/kg, intraperitoneally), ethanol with 3 doses (125, 250, and 500 mg/kg) of ethyl acetate flower and leaf extracts, and positive control (vitamin E 80 mg/kg). Animals were gavaged 30 min before ethanol injection for 28 days. Then, animals were killed and the livers were separated. Oxidative stress parameters, including reactive oxygen species, lipid peroxidation, and protein carbonyl as well as glutathione content, were evaluated. Also, histopathological examination was performed and assessment of blood alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total antioxidant capacity were evaluated. Ethanol significantly increased oxidative stress markers in liver. Interestingly, administration of both extracts significantly decreased oxidative stress markers in liver tissue and biochemical parameters in the plasma. In addition, abnormal pathological features were improved after treatment with flower and leaf extracts. These results suggested that V. odorata can be considered a candidate for improving conditions due to ethanol-induced tissue oxidative damage because of its antioxidant activity.

Authors+Show Affiliations

a Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. b Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.a Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. c Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.a Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. b Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.d Faculty of Medicine, Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran.a Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. c Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30308125

Citation

Habibi, Emran, et al. "Modulatory Effects of Viola Odorata Flower and Leaf Extracts Upon Oxidative Stress-related Damage in an Experimental Model of Ethanol-induced Hepatotoxicity." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 44, no. 5, 2019, pp. 521-527.
Habibi E, Arab-Nozari M, Elahi P, et al. Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress-related damage in an experimental model of ethanol-induced hepatotoxicity. Appl Physiol Nutr Metab. 2019;44(5):521-527.
Habibi, E., Arab-Nozari, M., Elahi, P., Ghasemi, M., & Shaki, F. (2019). Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress-related damage in an experimental model of ethanol-induced hepatotoxicity. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 44(5), pp. 521-527. doi:10.1139/apnm-2018-0559.
Habibi E, et al. Modulatory Effects of Viola Odorata Flower and Leaf Extracts Upon Oxidative Stress-related Damage in an Experimental Model of Ethanol-induced Hepatotoxicity. Appl Physiol Nutr Metab. 2019;44(5):521-527. PubMed PMID: 30308125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress-related damage in an experimental model of ethanol-induced hepatotoxicity. AU - Habibi,Emran, AU - Arab-Nozari,Milad, AU - Elahi,Pedram, AU - Ghasemi,Maryam, AU - Shaki,Fatemeh, Y1 - 2018/10/11/ PY - 2018/10/12/pubmed PY - 2019/9/7/medline PY - 2018/10/12/entrez KW - KW - antioxidant KW - antioxydant KW - ethanol KW - foie KW - liver KW - oxidative stress KW - stress oxydatif KW - toxicity KW - toxicité KW - éthanol SP - 521 EP - 527 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 44 IS - 5 N2 - Ethanol is the most widely abused drug in the world and its long-term use induces oxidative stress in the liver tissue. The aim of this study was to evaluate protective effect of Viola odorata against ethanol-induced hepatotoxicity in Wistar rat. Animals were divided into 9 groups as follows: control (normal saline), ethanol (10 mg/kg, intraperitoneally), ethanol with 3 doses (125, 250, and 500 mg/kg) of ethyl acetate flower and leaf extracts, and positive control (vitamin E 80 mg/kg). Animals were gavaged 30 min before ethanol injection for 28 days. Then, animals were killed and the livers were separated. Oxidative stress parameters, including reactive oxygen species, lipid peroxidation, and protein carbonyl as well as glutathione content, were evaluated. Also, histopathological examination was performed and assessment of blood alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total antioxidant capacity were evaluated. Ethanol significantly increased oxidative stress markers in liver. Interestingly, administration of both extracts significantly decreased oxidative stress markers in liver tissue and biochemical parameters in the plasma. In addition, abnormal pathological features were improved after treatment with flower and leaf extracts. These results suggested that V. odorata can be considered a candidate for improving conditions due to ethanol-induced tissue oxidative damage because of its antioxidant activity. SN - 1715-5320 UR - https://www.unboundmedicine.com/medline/citation/30308125/Modulatory_effects_of_Viola_odorata_flower_and_leaf_extracts_upon_oxidative_stress_related_damage_in_an_experimental_model_of_ethanol_induced_hepatotoxicity_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/apnm-2018-0559?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -