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The combination measles, mumps, rubella and varicella vaccine in healthy children.
Dev Biol Stand. 1986; 65:89-93.DB

Abstract

A clinical trial was conducted to compare the combination measles, mumps, rubella, varicella vaccine (MMRV) and the standard measles, mumps, rubella vaccine and subsequent varicella vaccine (MMR + V) in 15 to 17 month old healthy children. Both the MMRV and MMR + V schedules stimulated virtually 100% seroconversion for all component viruses. Mean antibody titers were similar for each virus component in the two vaccine groups. Clinical reactivity post immunization was also similar with 25-29% morbilliform rashes, 12-25% mild papulovesicular (varicella) rashes, and 12.5-18% temperature elevations above 101 degrees F. Antibodies to measles, mumps, and rubella viruses were persistent in 8/10 originally seronegative MMRV vaccinees and 5/5 MMR + V recipients tested. On MMRV recipient had a household exposure to chickenpox during the year postvaccination that resulted in a subclinical boost in varicella antibody titer. Two children in the MMR + V group had close varicella exposures: one developed mild varicella (20 lesions). There were no known exposures to natural measles, mumps, or rubella. Three of four MMRV vaccinees with low titer antibody to varicella prior to immunization had greater than four-fold rises in antibodies. The combination measles, mumps, rubella, varicella vaccine is an immunogenic, safe and cost effective approach to varicella immunization of healthy children.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3030864

Citation

Arbeter, A M., et al. "The Combination Measles, Mumps, Rubella and Varicella Vaccine in Healthy Children." Developments in Biological Standardization, vol. 65, 1986, pp. 89-93.
Arbeter AM, Baker L, Starr SE, et al. The combination measles, mumps, rubella and varicella vaccine in healthy children. Dev Biol Stand. 1986;65:89-93.
Arbeter, A. M., Baker, L., Starr, S. E., & Plotkin, S. A. (1986). The combination measles, mumps, rubella and varicella vaccine in healthy children. Developments in Biological Standardization, 65, 89-93.
Arbeter AM, et al. The Combination Measles, Mumps, Rubella and Varicella Vaccine in Healthy Children. Dev Biol Stand. 1986;65:89-93. PubMed PMID: 3030864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The combination measles, mumps, rubella and varicella vaccine in healthy children. AU - Arbeter,A M, AU - Baker,L, AU - Starr,S E, AU - Plotkin,S A, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 89 EP - 93 JF - Developments in biological standardization JO - Dev Biol Stand VL - 65 N2 - A clinical trial was conducted to compare the combination measles, mumps, rubella, varicella vaccine (MMRV) and the standard measles, mumps, rubella vaccine and subsequent varicella vaccine (MMR + V) in 15 to 17 month old healthy children. Both the MMRV and MMR + V schedules stimulated virtually 100% seroconversion for all component viruses. Mean antibody titers were similar for each virus component in the two vaccine groups. Clinical reactivity post immunization was also similar with 25-29% morbilliform rashes, 12-25% mild papulovesicular (varicella) rashes, and 12.5-18% temperature elevations above 101 degrees F. Antibodies to measles, mumps, and rubella viruses were persistent in 8/10 originally seronegative MMRV vaccinees and 5/5 MMR + V recipients tested. On MMRV recipient had a household exposure to chickenpox during the year postvaccination that resulted in a subclinical boost in varicella antibody titer. Two children in the MMR + V group had close varicella exposures: one developed mild varicella (20 lesions). There were no known exposures to natural measles, mumps, or rubella. Three of four MMRV vaccinees with low titer antibody to varicella prior to immunization had greater than four-fold rises in antibodies. The combination measles, mumps, rubella, varicella vaccine is an immunogenic, safe and cost effective approach to varicella immunization of healthy children. SN - 0301-5149 UR - https://www.unboundmedicine.com/medline/citation/3030864/The_combination_measles_mumps_rubella_and_varicella_vaccine_in_healthy_children_ L2 - https://www.diseaseinfosearch.org/result/6369 DB - PRIME DP - Unbound Medicine ER -