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End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography.
J Cardiovasc Imaging. 2018 Sep; 26(3):155-164.JC

Abstract

BACKGROUND

Arterial stiffening is a major contributing factor in the development of cardiovascular disease in patients with end-stage renal disease (ESRD). However, there is no gold standard for evaluating arterial stiffness. This study aimed to evaluate the newly developed speckle-tracking carotid strain imaging method in assessing arterial stiffness in patients with ESRD.

METHODS

In total, 85 patients with normal renal function (controls) and 36 with ESRD were enrolled in this single-center study. Carotid B-mode ultrasonography was performed for all patients. Arterial stiffness indices and strain parameters of the common carotid arteries were analyzed. Values were compared between the groups, and multivariate linear regression analysis was performed to assess the impact of ESRD on carotid strain.

RESULTS

There were no differences in the intima-media thickness, β stiffness index, and arterial compliance, but arterial distensibility was lower, and the elastic modulus and pulse wave velocity β (PWV) were higher among patients with ESRD (all p < 0.05), whether assessed in the longitudinal or transverse plane. Both longitudinal and transverse strain rates were reduced in patients with ESRD (all p < 0.05). In multivariate analyses, ESRD independently reduced both transverse radial strain and strain rate (all p < 0.05), and the transverse circumferential strain and strain rate (p < 0.05). However, all conventional aortic stiffness indices and longitudinal strain parameters were not associated with ESRD.

CONCLUSIONS

Speckle-tracking carotid strain ultrasonography was successfully performed in both normal subjects and patients with ESRD. Multidirectional carotid strain analyses may provide more value than conventional aortic stiffness indices for risk stratification in patients with ESRD.

Authors+Show Affiliations

Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.Medical Imaging Research Group, Samsung Medison, Seoul, Korea.Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea. Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30310883

Citation

Lee, Sang-Eun, et al. "End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography." Journal of Cardiovascular Imaging, vol. 26, no. 3, 2018, pp. 155-164.
Lee SE, Lee J, Yoo TH, et al. End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography. J Cardiovasc Imaging. 2018;26(3):155-164.
Lee, S. E., Lee, J., Yoo, T. H., Cho, I. J., & Chang, H. J. (2018). End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography. Journal of Cardiovascular Imaging, 26(3), 155-164. https://doi.org/10.4250/jcvi.2018.26.e16
Lee SE, et al. End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography. J Cardiovasc Imaging. 2018;26(3):155-164. PubMed PMID: 30310883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - End-Stage Renal Disease Impairs the Multidirectional Movements of the Common Carotid Artery: Assessment Using Dimensional Speckle-Tracking Carotid Strain Ultrasonography. AU - Lee,Sang-Eun, AU - Lee,Jinyong, AU - Yoo,Tae-Hyun, AU - Cho,In-Jeong, AU - Chang,Hyuk-Jae, Y1 - 2018/09/17/ PY - 2018/07/23/received PY - 2018/09/03/revised PY - 2018/09/04/accepted PY - 2018/10/13/entrez PY - 2018/10/13/pubmed PY - 2018/10/13/medline KW - Atherosclerosis KW - Common carotid artery KW - End stage renal disease KW - Strain KW - Ultrasonography SP - 155 EP - 164 JF - Journal of cardiovascular imaging JO - J Cardiovasc Imaging VL - 26 IS - 3 N2 - BACKGROUND: Arterial stiffening is a major contributing factor in the development of cardiovascular disease in patients with end-stage renal disease (ESRD). However, there is no gold standard for evaluating arterial stiffness. This study aimed to evaluate the newly developed speckle-tracking carotid strain imaging method in assessing arterial stiffness in patients with ESRD. METHODS: In total, 85 patients with normal renal function (controls) and 36 with ESRD were enrolled in this single-center study. Carotid B-mode ultrasonography was performed for all patients. Arterial stiffness indices and strain parameters of the common carotid arteries were analyzed. Values were compared between the groups, and multivariate linear regression analysis was performed to assess the impact of ESRD on carotid strain. RESULTS: There were no differences in the intima-media thickness, β stiffness index, and arterial compliance, but arterial distensibility was lower, and the elastic modulus and pulse wave velocity β (PWV) were higher among patients with ESRD (all p < 0.05), whether assessed in the longitudinal or transverse plane. Both longitudinal and transverse strain rates were reduced in patients with ESRD (all p < 0.05). In multivariate analyses, ESRD independently reduced both transverse radial strain and strain rate (all p < 0.05), and the transverse circumferential strain and strain rate (p < 0.05). However, all conventional aortic stiffness indices and longitudinal strain parameters were not associated with ESRD. CONCLUSIONS: Speckle-tracking carotid strain ultrasonography was successfully performed in both normal subjects and patients with ESRD. Multidirectional carotid strain analyses may provide more value than conventional aortic stiffness indices for risk stratification in patients with ESRD. SN - 2586-7296 UR - https://www.unboundmedicine.com/medline/citation/30310883/End_Stage_Renal_Disease_Impairs_the_Multidirectional_Movements_of_the_Common_Carotid_Artery:_Assessment_Using_Dimensional_Speckle_Tracking_Carotid_Strain_Ultrasonography_ L2 - https://e-jcvi.org/DOIx.php?id=10.4250/jcvi.2018.26.e16 DB - PRIME DP - Unbound Medicine ER -
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