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Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children.
Dig Dis Sci 2019; 64(1):173-181DD

Abstract

BACKGROUND/AIMS

The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus.

METHODS

This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies. Subjects with selective IgA deficiency were further tested for IgG-tTG. Small intestinal biopsies were performed on all subjects with tTG antibody positivity. Risk factors and symptoms related to CD were evaluated using questionnaires in both the CD and control groups.

RESULTS

Of the 3792 subjects, 39 were antibody positive (IgA-tTG was positive only in 14 subjects, IgA-tTG plus IgA-EMA in 21 subjects, and IgG-tTG in 4 subjects). IgA deficiency was detected in 11 subjects (0.29%). IgG-tTG was positive in 4 subjects with IgA deficiency (36.3%). Intestinal biopsies were performed on 28 of the 39 seropositive subjects. The biopsy findings of 15 children were consistent with CD (IgA-tTG positive in 3, IgA-tTG and IgA-EMA positive in 10, and IgG-tTG positive in 2). Thus, biopsies confirmed CD in 1:256 children (0.39%).

CONCLUSIONS

Our study, which is the first study of school-aged children from the northern region of Cyprus, revealed that CD is a prevalent disease in this region.

Authors+Show Affiliations

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Health Sciences, Okmeydani Education and Training Hospital, Istanbul, Turkey. ofbeser@gmail.com.Director of Basic Health Care Office, Northern Cyprus Ministry of Health, Nicosia, Cyprus.Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Ege University Medical Faculty, Izmir, Turkey.Department of Pediatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.Cyprus Turkish Pediatric Association, Nicosia, Cyprus.Department of Pathology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.Department of Medical Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30311156

Citation

Beser, Omer Faruk, et al. "Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children." Digestive Diseases and Sciences, vol. 64, no. 1, 2019, pp. 173-181.
Beser OF, Gulluelli E, Cullu Cokugras F, et al. Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children. Dig Dis Sci. 2019;64(1):173-181.
Beser, O. F., Gulluelli, E., Cullu Cokugras, F., Erkan, T., Kutlu, T., Yagci, R. V., ... Kucur, M. (2019). Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children. Digestive Diseases and Sciences, 64(1), pp. 173-181. doi:10.1007/s10620-018-5320-0.
Beser OF, et al. Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children. Dig Dis Sci. 2019;64(1):173-181. PubMed PMID: 30311156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and Clinical Features of Celiac Disease in Healthy School-Aged Children. AU - Beser,Omer Faruk, AU - Gulluelli,Emine, AU - Cullu Cokugras,Fugen, AU - Erkan,Tulay, AU - Kutlu,Tufan, AU - Yagci,Rasit Vural, AU - Erbek Alp,Firuze, AU - Ercal,Gulten, AU - Kepil,Nuray, AU - Kucur,Mine, AU - ,, Y1 - 2018/10/12/ PY - 2018/05/02/received PY - 2018/10/03/accepted PY - 2018/10/13/pubmed PY - 2019/2/5/medline PY - 2018/10/13/entrez KW - Celiac disease KW - Children KW - IgA anti-tissue transglutaminase KW - Prevalence SP - 173 EP - 181 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 64 IS - 1 N2 - BACKGROUND/AIMS: The aim of this study was to determine the prevalence of celiac disease (CD) in healthy school-aged children in the northern region of Cyprus and to investigate the existence of potential markers that may accompany CD. This is the first study to measure the prevalence of CD in the northern region of Cyprus. METHODS: This study included 3792 school-aged children who were between the ages of 6 and 10 years between January 2015 and October 2016. CD was screened using total serum IgA, IgA anti-tissue transglutaminase (tTG), and IgA antiendomysial (EMA) antibodies. Subjects with selective IgA deficiency were further tested for IgG-tTG. Small intestinal biopsies were performed on all subjects with tTG antibody positivity. Risk factors and symptoms related to CD were evaluated using questionnaires in both the CD and control groups. RESULTS: Of the 3792 subjects, 39 were antibody positive (IgA-tTG was positive only in 14 subjects, IgA-tTG plus IgA-EMA in 21 subjects, and IgG-tTG in 4 subjects). IgA deficiency was detected in 11 subjects (0.29%). IgG-tTG was positive in 4 subjects with IgA deficiency (36.3%). Intestinal biopsies were performed on 28 of the 39 seropositive subjects. The biopsy findings of 15 children were consistent with CD (IgA-tTG positive in 3, IgA-tTG and IgA-EMA positive in 10, and IgG-tTG positive in 2). Thus, biopsies confirmed CD in 1:256 children (0.39%). CONCLUSIONS: Our study, which is the first study of school-aged children from the northern region of Cyprus, revealed that CD is a prevalent disease in this region. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/30311156/Prevalence_and_Clinical_Features_of_Celiac_Disease_in_Healthy_School_Aged_Children_ L2 - https://doi.org/10.1007/s10620-018-5320-0 DB - PRIME DP - Unbound Medicine ER -