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Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases.
Ocul Immunol Inflamm. 2019; 27(2):211-218.OI

Abstract

PURPOSE

To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy.

METHODS

Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR).

RESULTS

The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05).

CONCLUSION

Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease.

Authors+Show Affiliations

a Private Inflammatory Eye Disease Clinic , Tel-Aviv , Israel.b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.c Department of Ophthalmology , Hadassah Medical Center, The Hebrew University Hadassah Medical School , Jerusalem , Israel.d Department of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Israel Institute of Technology , Haifa , Israel.e Department of Ophthalmology, Faculty of Medicine in the Galilee , Galilee Medical Center, Bar Ilan University , Naharia , Israel.f The Goldschleger Eye Institute, Department of Ophthalmology, Sheba Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Ramat Gan , Israel.g Department of Ophthalmology , Barzilai University Medical Center, Ben-Gurion University , Ashkelon , Israel.h Department of Ophthalmology, Wolfson Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Holon , Israel.b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.c Department of Ophthalmology , Hadassah Medical Center, The Hebrew University Hadassah Medical School , Jerusalem , Israel.d Department of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Israel Institute of Technology , Haifa , Israel.b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30311824

Citation

Neumann, Ron, et al. "Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases." Ocular Immunology and Inflammation, vol. 27, no. 2, 2019, pp. 211-218.
Neumann R, Barequet D, Rosenblatt A, et al. Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. Ocul Immunol Inflamm. 2019;27(2):211-218.
Neumann, R., Barequet, D., Rosenblatt, A., Amer, R., Ben-Arie-Weintrob, Y., Hareuveni-Blum, T., Vishnevskia-Dai, V., Raskin, E., Blumenfeld, O., Shulman, S., Sanchez, J. M., Flores, V., & Habot-Wilner, Z. (2019). Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. Ocular Immunology and Inflammation, 27(2), 211-218. https://doi.org/10.1080/09273948.2018.1483521
Neumann R, et al. Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. Ocul Immunol Inflamm. 2019;27(2):211-218. PubMed PMID: 30311824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herpetic Anterior Uveitis - Analysis of Presumed and PCR Proven Cases. AU - Neumann,Ron, AU - Barequet,Dana, AU - Rosenblatt,Amir, AU - Amer,Radgonde, AU - Ben-Arie-Weintrob,Yael, AU - Hareuveni-Blum,Tamar, AU - Vishnevskia-Dai,Vicktoria, AU - Raskin,Eyal, AU - Blumenfeld,Oren, AU - Shulman,Shiri, AU - Sanchez,Juan M, AU - Flores,Victor, AU - Habot-Wilner,Zohar, Y1 - 2018/10/12/ PY - 2018/10/13/pubmed PY - 2020/1/7/medline PY - 2018/10/13/entrez KW - Anterior uveitis KW - CMV KW - HSV KW - PCR KW - VZV KW - cytomegalovirus KW - herpes simplex virus KW - herpetic anterior uveitis KW - polymerase chain reaction KW - varicella zoster virus SP - 211 EP - 218 JF - Ocular immunology and inflammation JO - Ocul. Immunol. Inflamm. VL - 27 IS - 2 N2 - PURPOSE: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. METHODS: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). RESULTS: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05). CONCLUSION: Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/30311824/Herpetic_Anterior_Uveitis___Analysis_of_Presumed_and_PCR_Proven_Cases_ L2 - http://www.tandfonline.com/doi/full/10.1080/09273948.2018.1483521 DB - PRIME DP - Unbound Medicine ER -