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A systematic review and meta-analysis of the effects of soy on serum hs-CRP.
Clin Nutr. 2019 06; 38(3):996-1011.CN

Abstract

BACKGROUND & AIM

The results of studies about the effect of soy products on serum highly sensitive C-reactive protein (hs-CRP) are inconsistent. The aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to investigate the effect of soy products intake on serum hs-CRP concentration.

METHODS

We searched PubMed, EMBASE, Science Direct, ISI Web of Science, Google Scholar and Cochrane Central Register of Controlled Trials up to December 2016 without language restrictions. Random-effect model was used for quantitative data synthesis.

RESULTS

Thirty-six studies were included in our analyses. A meta-analysis revealed a non-significant reduction in serum hs-CRP concentrations following soy products consumption, -0.19 (mg/L) (95% CI: -0.49 to 0.09; I[2] = 95.6%). Subgroup analyses suggested that natural soya products may reduce plasma levels of CRP by -0.18 mg/L (95% CI: -0.28 to -0.08; I[2]: 11.6) in comparison to other source of isoflavones (soya extracts, supplements). Moreover, the effect was stronger among subjects with baseline hs-CRP concentrations of less than 2.52 mg/L, -0.15 (95% CI: -0.27 to -0.02; I[2]: 34.6). A meta-regression analysis revealed that dosage of isoflavones seems to be a strong predictor of the effect of soya on serum hs-CRP levels.

CONCLUSION

Present review of RCTs published up to December 2016 did not provide strong evidence regarding the beneficial effect of soya products consumption on blood hs-CRP concentrations. However, it appears that natural soya products may reduce plasma levels of hs-CRP in comparison to other source of isoflavones. Large and well-designed studies are recommended to confirm this conclusion.

SYSTEMATIC REVIEW REGISTRATION

PROSPERO CRD42018069371.

Authors+Show Affiliations

Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Student Research Committee, Department of Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.Nutritional Sciences Department, Faculty of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.Research Center for Evidence-Based Medicine (RCEBM), Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Abbasalizad_m@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

30314925

Citation

Khodarahmi, Mahdieh, et al. "A Systematic Review and Meta-analysis of the Effects of Soy On Serum Hs-CRP." Clinical Nutrition (Edinburgh, Scotland), vol. 38, no. 3, 2019, pp. 996-1011.
Khodarahmi M, Jafarabadi MA, Moludi J, et al. A systematic review and meta-analysis of the effects of soy on serum hs-CRP. Clin Nutr. 2019;38(3):996-1011.
Khodarahmi, M., Jafarabadi, M. A., Moludi, J., & Abbasalizad Farhangi, M. (2019). A systematic review and meta-analysis of the effects of soy on serum hs-CRP. Clinical Nutrition (Edinburgh, Scotland), 38(3), 996-1011. https://doi.org/10.1016/j.clnu.2018.09.007
Khodarahmi M, et al. A Systematic Review and Meta-analysis of the Effects of Soy On Serum Hs-CRP. Clin Nutr. 2019;38(3):996-1011. PubMed PMID: 30314925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of the effects of soy on serum hs-CRP. AU - Khodarahmi,Mahdieh, AU - Jafarabadi,Mohammad Asghari, AU - Moludi,Jalal, AU - Abbasalizad Farhangi,Mahdieh, Y1 - 2018/09/12/ PY - 2018/05/16/received PY - 2018/08/13/revised PY - 2018/09/06/accepted PY - 2018/10/14/pubmed PY - 2020/5/29/medline PY - 2018/10/14/entrez KW - C-reactive protein KW - Inflammation KW - Isoflavones KW - Meta-analysis KW - Soy SP - 996 EP - 1011 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 38 IS - 3 N2 - BACKGROUND & AIM: The results of studies about the effect of soy products on serum highly sensitive C-reactive protein (hs-CRP) are inconsistent. The aim of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to investigate the effect of soy products intake on serum hs-CRP concentration. METHODS: We searched PubMed, EMBASE, Science Direct, ISI Web of Science, Google Scholar and Cochrane Central Register of Controlled Trials up to December 2016 without language restrictions. Random-effect model was used for quantitative data synthesis. RESULTS: Thirty-six studies were included in our analyses. A meta-analysis revealed a non-significant reduction in serum hs-CRP concentrations following soy products consumption, -0.19 (mg/L) (95% CI: -0.49 to 0.09; I[2] = 95.6%). Subgroup analyses suggested that natural soya products may reduce plasma levels of CRP by -0.18 mg/L (95% CI: -0.28 to -0.08; I[2]: 11.6) in comparison to other source of isoflavones (soya extracts, supplements). Moreover, the effect was stronger among subjects with baseline hs-CRP concentrations of less than 2.52 mg/L, -0.15 (95% CI: -0.27 to -0.02; I[2]: 34.6). A meta-regression analysis revealed that dosage of isoflavones seems to be a strong predictor of the effect of soya on serum hs-CRP levels. CONCLUSION: Present review of RCTs published up to December 2016 did not provide strong evidence regarding the beneficial effect of soya products consumption on blood hs-CRP concentrations. However, it appears that natural soya products may reduce plasma levels of hs-CRP in comparison to other source of isoflavones. Large and well-designed studies are recommended to confirm this conclusion. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018069371. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/30314925/A_systematic_review_and_meta_analysis_of_the_effects_of_soy_on_serum_hs_CRP_ DB - PRIME DP - Unbound Medicine ER -