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A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis.
Curr Pharm Biotechnol. 2018; 19(10):827-838.CP

Abstract

Atopic dermatitis is a chronic inflammatory skin disease that commonly occurs in early childhood. To date, the pharmacological treatment of atopic dermatitis is far from ideal, poses several limitations, and constantly requires novel approaches. The theory that appropriate colonization of gut bacteria during infancy influences the development of the immune system has prompted numerous clinical trials that have evaluated the effectiveness of probiotic supplementation for the prevention and treatment of atopic eczema in children. In addition, topical application of probiotics has been demonstrated to improve the skin's barrier function, which might contribute to reduce the severity of atopic dermatitis. In this article, we review the literature and data regarding the use of probiotics, both by oral administration and topical application, for the treatment of atopic dermatitis. We also summarize the knowledge on the potential mechanisms by which probiotics influence the gut and exert their skin effects. Probiotic supplementation seems to be an attractive strategy to prevent and treat pediatric atopic dermatitis. However, to enable the treatment to be fully effective, the period of supplementation should be considered. Moreover, in future studies, a combination of probiotic supplementation and simultaneous topical application of creams containing probiotics might also be considered.

Authors+Show Affiliations

Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30317995

Citation

Marcinkowska, Monika, et al. "A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis." Current Pharmaceutical Biotechnology, vol. 19, no. 10, 2018, pp. 827-838.
Marcinkowska M, Zagórska A, Fajkis N, et al. A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis. Curr Pharm Biotechnol. 2018;19(10):827-838.
Marcinkowska, M., Zagórska, A., Fajkis, N., Kołaczkowski, M., & Paśko, P. (2018). A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis. Current Pharmaceutical Biotechnology, 19(10), 827-838. https://doi.org/10.2174/1389201019666181008113149
Marcinkowska M, et al. A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis. Curr Pharm Biotechnol. 2018;19(10):827-838. PubMed PMID: 30317995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Review of Probiotic Supplementation and Feasibility of Topical Application for the Treatment of Pediatric Atopic Dermatitis. AU - Marcinkowska,Monika, AU - Zagórska,Agnieszka, AU - Fajkis,Nikola, AU - Kołaczkowski,Marcin, AU - Paśko,Paweł, PY - 2018/07/03/received PY - 2018/08/31/revised PY - 2018/09/27/accepted PY - 2018/10/16/pubmed PY - 2019/3/21/medline PY - 2018/10/16/entrez KW - Atopic eczema KW - immunomodulation KW - pediatric atopic dermatitis KW - probiotic supplementation KW - topical application of probiotics. SP - 827 EP - 838 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 19 IS - 10 N2 - Atopic dermatitis is a chronic inflammatory skin disease that commonly occurs in early childhood. To date, the pharmacological treatment of atopic dermatitis is far from ideal, poses several limitations, and constantly requires novel approaches. The theory that appropriate colonization of gut bacteria during infancy influences the development of the immune system has prompted numerous clinical trials that have evaluated the effectiveness of probiotic supplementation for the prevention and treatment of atopic eczema in children. In addition, topical application of probiotics has been demonstrated to improve the skin's barrier function, which might contribute to reduce the severity of atopic dermatitis. In this article, we review the literature and data regarding the use of probiotics, both by oral administration and topical application, for the treatment of atopic dermatitis. We also summarize the knowledge on the potential mechanisms by which probiotics influence the gut and exert their skin effects. Probiotic supplementation seems to be an attractive strategy to prevent and treat pediatric atopic dermatitis. However, to enable the treatment to be fully effective, the period of supplementation should be considered. Moreover, in future studies, a combination of probiotic supplementation and simultaneous topical application of creams containing probiotics might also be considered. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/30317995/A_Review_of_Probiotic_Supplementation_and_Feasibility_of_Topical_Application_for_the_Treatment_of_Pediatric_Atopic_Dermatitis_ L2 - http://www.eurekaselect.com/166012/article DB - PRIME DP - Unbound Medicine ER -