TY - JOUR T1 - Radiologic and Pathologic Features Associated With Upgrade of Atypical Ductal Hyperplasia at Surgical Excision. AU - Williams,Kristin E, AU - Amin,Amanda, AU - Hill,Jacqueline, AU - Walter,Carissa, AU - Inciardi,Marc, AU - Gatewood,Jason, AU - Redick,Mark, AU - Wick,Jo, AU - Hunt,Suzanne, AU - Winblad,Onalisa, Y1 - 2018/10/12/ PY - 2018/06/04/received PY - 2018/09/07/revised PY - 2018/09/12/accepted PY - 2018/10/16/pubmed PY - 2020/5/7/medline PY - 2018/10/16/entrez KW - atypical ductal hyperplasia KW - breast cancer KW - ductal carcinoma in situ SP - 893 EP - 899 JF - Academic radiology JO - Acad Radiol VL - 26 IS - 7 N2 - RATIONALE AND OBJECTIVES: To evaluate radiologic and pathologic features associated with upgrade of atypical ductal hyperplasia (ADH) to ductal carcinoma in situ or invasive breast cancer at surgical excision, in order to identify patients who may consider alternatives to excision. MATERIALS AND METHODS: This retrospective analysis examined patients who underwent surgical excision of biopsy-proven ADH at our institution. Imaging and pathology from biopsy were reviewed to determine radiologic (lesion size, radiologic abnormality, biopsy type, needle gauge, number of cores, percent of lesion removed) and pathologic features (histologic calcifications, presence of necrosis, micropapillary features, extent of ADH) associated with ADH upgrade. RESULTS: One hundred twenty four cases of percutaneous biopsy-proven ADH with subsequent excision were included. The overall upgrade rate was 17.7% (n = 22), with 17 cases to ductal carcinoma in situ and five to invasive cancer. Radiologic features associated with a lower upgrade rate were smaller lesion size (p = 0.032) and larger percent of lesion removed at biopsy (p = 0.047). Larger needle gauge at biopsy (p = 0.070), absence of necrosis (p = 0.051) and focal ADH (<3 foci, p = 0.12) were nearly associated with a lower rate of upgrade and were included for the purpose of multi parameter analyses. CONCLUSION: For women with ADH identified on percutaneous biopsy, the risk of upgrade may in part be determined by lesion size, percent of lesion removed at biopsy, presence of necrosis, and extent of ADH. Using a combination of these radiographic and pathologic features to stratify patients with biopsy-proven ADH may help identify women who could be considered for alternative treatment options. SN - 1878-4046 UR - https://www.unboundmedicine.com/medline/citation/30318287/Radiologic_and_Pathologic_Features_Associated_With_Upgrade_of_Atypical_Ductal_Hyperplasia_at_Surgical_Excision_ DB - PRIME DP - Unbound Medicine ER -