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Relationship between high-sensitivity C-reactive protein and subclinical carotid atherosclerosis stratified by glucose metabolic status in Chinese adults.
Clin Cardiol 2019; 42(1):39-46CC

Abstract

BACKGROUND

Atherosclerosis is an inflammatory disease. Many studies demonstrated that hyperglycemia is not only increased inflammatory response, but also is a cause of atherosclerosis, implying that glucose metabolic status may be an important stratification factor when analyzing the relationship between inflammatory levels and subclinical carotid atherosclerosis. The aim of the present study is to assess the relationship between inflammatory levels and subclinical carotid atherosclerosis, stratified by different glucose metabolic status in a general population.

METHODS

An assessment was performed in 7975 participants living in Tianjin, China. In the present study, we examined subclinical carotid atherosclerosis, as defined by increased carotid intima-media thickness [IMT] and plaques. Measurements were performed using a carotid artery B-mode ultrasound system. The glucose metabolic status was defined by the criteria of the American Diabetes Association, and high-sensitivity C-reactive protein (hs-CRP) as an inflammatory indicator, was measured by immunoturbidimetric assay. Multiple logistic models were used to assess a stratified relationship between hs-CRP levels and subclinical carotid atherosclerosis. Strata were defined according to glucose metabolic status.

RESULTS

The prevalence of increased IMT and plaques were 27.3% and 21.3%, respectively. The adjusted odds ratios (95% confidence interval) for IMT across hs-CRP quartiles were as follows: 1.00 (reference), 1.10(0.88-1.38), 1.08(0.86-1.35) and 1.32(1.06-1.66) in blood glucose-normal subjects; 1.00 (reference), 1.33(0.92-1.91), 1.33(0.93-1.91), and 1.59(1.10-2.30) in prediabetic subjects; 1.00 (reference), 0.94(0.54-1.62), 1.17(0.65-2.12) and 0.98(0.55-1.76) in diabetic subjects, respectively. Similar results were observed for plaques.

CONCLUSIONS

Our results suggest that inflammatory levels are differently related to subclinical carotid atherosclerosis by the different glucose metabolic status.

Authors+Show Affiliations

Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Tianjin Institute of Environmental & Operational Medicine, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China.Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30318598

Citation

Su, Haiyan, et al. "Relationship Between High-sensitivity C-reactive Protein and Subclinical Carotid Atherosclerosis Stratified By Glucose Metabolic Status in Chinese Adults." Clinical Cardiology, vol. 42, no. 1, 2019, pp. 39-46.
Su H, Pei Y, Tian C, et al. Relationship between high-sensitivity C-reactive protein and subclinical carotid atherosclerosis stratified by glucose metabolic status in Chinese adults. Clin Cardiol. 2019;42(1):39-46.
Su, H., Pei, Y., Tian, C., Zhang, Q., Liu, L., Meng, G., ... Niu, K. (2019). Relationship between high-sensitivity C-reactive protein and subclinical carotid atherosclerosis stratified by glucose metabolic status in Chinese adults. Clinical Cardiology, 42(1), pp. 39-46. doi:10.1002/clc.23095.
Su H, et al. Relationship Between High-sensitivity C-reactive Protein and Subclinical Carotid Atherosclerosis Stratified By Glucose Metabolic Status in Chinese Adults. Clin Cardiol. 2019;42(1):39-46. PubMed PMID: 30318598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between high-sensitivity C-reactive protein and subclinical carotid atherosclerosis stratified by glucose metabolic status in Chinese adults. AU - Su,Haiyan, AU - Pei,Yinghua, AU - Tian,Chunling, AU - Zhang,Qing, AU - Liu,Li, AU - Meng,Ge, AU - Yao,Zhanxin, AU - Wu,Hongmei, AU - Xia,Yang, AU - Bao,Xue, AU - Gu,Yeqing, AU - Sun,Shaomei, AU - Wang,Xing, AU - Zhou,Ming, AU - Jia,Qiyu, AU - Song,Kun, AU - Sun,Zhong, AU - Niu,Kaijun, Y1 - 2018/12/10/ PY - 2018/05/20/received PY - 2018/10/10/revised PY - 2018/10/11/accepted PY - 2018/10/16/pubmed PY - 2019/5/2/medline PY - 2018/10/16/entrez KW - glucose metabolic status KW - high sensitivity C-reactive protein KW - subclinical carotid atherosclerosis SP - 39 EP - 46 JF - Clinical cardiology JO - Clin Cardiol VL - 42 IS - 1 N2 - BACKGROUND: Atherosclerosis is an inflammatory disease. Many studies demonstrated that hyperglycemia is not only increased inflammatory response, but also is a cause of atherosclerosis, implying that glucose metabolic status may be an important stratification factor when analyzing the relationship between inflammatory levels and subclinical carotid atherosclerosis. The aim of the present study is to assess the relationship between inflammatory levels and subclinical carotid atherosclerosis, stratified by different glucose metabolic status in a general population. METHODS: An assessment was performed in 7975 participants living in Tianjin, China. In the present study, we examined subclinical carotid atherosclerosis, as defined by increased carotid intima-media thickness [IMT] and plaques. Measurements were performed using a carotid artery B-mode ultrasound system. The glucose metabolic status was defined by the criteria of the American Diabetes Association, and high-sensitivity C-reactive protein (hs-CRP) as an inflammatory indicator, was measured by immunoturbidimetric assay. Multiple logistic models were used to assess a stratified relationship between hs-CRP levels and subclinical carotid atherosclerosis. Strata were defined according to glucose metabolic status. RESULTS: The prevalence of increased IMT and plaques were 27.3% and 21.3%, respectively. The adjusted odds ratios (95% confidence interval) for IMT across hs-CRP quartiles were as follows: 1.00 (reference), 1.10(0.88-1.38), 1.08(0.86-1.35) and 1.32(1.06-1.66) in blood glucose-normal subjects; 1.00 (reference), 1.33(0.92-1.91), 1.33(0.93-1.91), and 1.59(1.10-2.30) in prediabetic subjects; 1.00 (reference), 0.94(0.54-1.62), 1.17(0.65-2.12) and 0.98(0.55-1.76) in diabetic subjects, respectively. Similar results were observed for plaques. CONCLUSIONS: Our results suggest that inflammatory levels are differently related to subclinical carotid atherosclerosis by the different glucose metabolic status. SN - 1932-8737 UR - https://www.unboundmedicine.com/medline/citation/30318598/Relationship_between_high_sensitivity_C_reactive_protein_and_subclinical_carotid_atherosclerosis_stratified_by_glucose_metabolic_status_in_Chinese_adults_ L2 - https://doi.org/10.1002/clc.23095 DB - PRIME DP - Unbound Medicine ER -