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Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic.
Brain Res. 2019 02 01; 1704:161-163.BR

Abstract

Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability to reduce infarct sizes and preclude functional impairments in rats subjected to ischemic stroke. This commentary highlights Nestorone's properties as a progestin, its neuroprotective capabilities in animal studies, and how the Tanaka team's findings and previous clinical trials contribute to Nestorone's translation into a therapeutic agent for stroke and other neurological diseases.

Authors+Show Affiliations

Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA.Population Council, Center for Biomedical Research, 1230 York Avenue, New York, NY 10065, USA.Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA. Electronic address: cborlong@health.usf.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

30321495

Citation

Tuazon, Julian P., et al. "Beyond Contraception and Hormone Replacement Therapy: Advancing Nestorone to a Neuroprotective Drug in the Clinic." Brain Research, vol. 1704, 2019, pp. 161-163.
Tuazon JP, Sitruk-Ware R, Borlongan CV. Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic. Brain Res. 2019;1704:161-163.
Tuazon, J. P., Sitruk-Ware, R., & Borlongan, C. V. (2019). Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic. Brain Research, 1704, 161-163. https://doi.org/10.1016/j.brainres.2018.10.014
Tuazon JP, Sitruk-Ware R, Borlongan CV. Beyond Contraception and Hormone Replacement Therapy: Advancing Nestorone to a Neuroprotective Drug in the Clinic. Brain Res. 2019 02 1;1704:161-163. PubMed PMID: 30321495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beyond contraception and hormone replacement therapy: Advancing Nestorone to a neuroprotective drug in the clinic. AU - Tuazon,Julian P, AU - Sitruk-Ware,Regine, AU - Borlongan,Cesario V, Y1 - 2018/10/12/ PY - 2018/09/19/received PY - 2018/10/11/accepted PY - 2018/10/16/pubmed PY - 2020/2/12/medline PY - 2018/10/16/entrez KW - Central nervous system KW - Nestorone KW - Neurological disease KW - Neuroprotection KW - Progestin KW - Stroke SP - 161 EP - 163 JF - Brain research JO - Brain Res. VL - 1704 N2 - Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's ability to reduce infarct sizes and preclude functional impairments in rats subjected to ischemic stroke. This commentary highlights Nestorone's properties as a progestin, its neuroprotective capabilities in animal studies, and how the Tanaka team's findings and previous clinical trials contribute to Nestorone's translation into a therapeutic agent for stroke and other neurological diseases. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/30321495/Beyond_contraception_and_hormone_replacement_therapy:_Advancing_Nestorone_to_a_neuroprotective_drug_in_the_clinic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(18)30526-2 DB - PRIME DP - Unbound Medicine ER -