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Resting-state network connectivity in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson's disease.
J Neurol Sci. 2018 12 15; 395:147-152.JN

Abstract

BACKGROUND

Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR), tremor-dominant (PDTD) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naïve PDAR patients.

METHOD

Resting-state functional MRI (rs-fMRI) data was collected in 20 cognitively unimpaired early-stage drug-naïve PDAR patients and 20 age-, gender- and cognition- matched healthy controls (HCs). Group-level independent component analysis (ICA) was used to investigate changes in functional connectivity (FC) within the DMN between PDAR and HCs groups, and relationships between the DMN and FPN/DAN were evaluated by seed-based approach.

RESULTS

In PDAR patients, a significantly decreased FC, as compared with HCs, was observed in the left inferior parietal lobule (IPL) within the DMN. And the left IPL had a reduced FC with the left anterior cingulate cortex (ACC), left superior frontal gyrus (SFG), and left precuneus. However, no differences were detected in the FC between the left IPL and FPN/DAN. In addition, cognitive scores on the brief visuospatial memory test revised (BVMT-R), representing for cognitive memory domain, were positively correlated with the FC of the left IPL with bilateral SFG.

CONCLUSIONS

Our study mainly revealed altered within-DMN connectivity in cognitively unimpaired PDAR patients, which could provide further insights into the mechanism underlying cognitive decline evolution in the PD subtype.

Authors+Show Affiliations

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: huaxigong@126.com.Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address: hfshang2002@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30321795

Citation

Hou, Yanbing, et al. "Resting-state Network Connectivity in Cognitively Unimpaired Drug-naïve Patients With Rigidity-dominant Parkinson's Disease." Journal of the Neurological Sciences, vol. 395, 2018, pp. 147-152.
Hou Y, Yang J, Luo C, et al. Resting-state network connectivity in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson's disease. J Neurol Sci. 2018;395:147-152.
Hou, Y., Yang, J., Luo, C., Ou, R., Zou, Y., Song, W., Gong, Q., & Shang, H. (2018). Resting-state network connectivity in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson's disease. Journal of the Neurological Sciences, 395, 147-152. https://doi.org/10.1016/j.jns.2018.10.003
Hou Y, et al. Resting-state Network Connectivity in Cognitively Unimpaired Drug-naïve Patients With Rigidity-dominant Parkinson's Disease. J Neurol Sci. 2018 12 15;395:147-152. PubMed PMID: 30321795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting-state network connectivity in cognitively unimpaired drug-naïve patients with rigidity-dominant Parkinson's disease. AU - Hou,Yanbing, AU - Yang,Jing, AU - Luo,Chunyan, AU - Ou,Ruwei, AU - Zou,Yutong, AU - Song,Wei, AU - Gong,Qiyong, AU - Shang,Huifang, Y1 - 2018/10/03/ PY - 2017/09/13/received PY - 2018/09/02/revised PY - 2018/10/02/accepted PY - 2018/10/16/pubmed PY - 2019/7/25/medline PY - 2018/10/16/entrez KW - Cognition KW - Functional connectivity KW - Independent component analysis (ICA) KW - Parkinson's disease KW - Resting state fMRI KW - Subtype SP - 147 EP - 152 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 395 N2 - BACKGROUND: Parkinson's disease (PD) could be classified into akinetic-rigidity (PDAR), tremor-dominant (PDTD) and mixed subtypes. PDAR patients are more prone to develop cognitive deficits. The default mode network (DMN), fronto-parietal network (FPN) and dorsal attention network (DAN) play important roles in cognitive processing. Our aim was to evaluate changes in connectivity patterns of the DMN, and its interrelation with the FPN and DAN in cognitively unimpaired drug-naïve PDAR patients. METHOD: Resting-state functional MRI (rs-fMRI) data was collected in 20 cognitively unimpaired early-stage drug-naïve PDAR patients and 20 age-, gender- and cognition- matched healthy controls (HCs). Group-level independent component analysis (ICA) was used to investigate changes in functional connectivity (FC) within the DMN between PDAR and HCs groups, and relationships between the DMN and FPN/DAN were evaluated by seed-based approach. RESULTS: In PDAR patients, a significantly decreased FC, as compared with HCs, was observed in the left inferior parietal lobule (IPL) within the DMN. And the left IPL had a reduced FC with the left anterior cingulate cortex (ACC), left superior frontal gyrus (SFG), and left precuneus. However, no differences were detected in the FC between the left IPL and FPN/DAN. In addition, cognitive scores on the brief visuospatial memory test revised (BVMT-R), representing for cognitive memory domain, were positively correlated with the FC of the left IPL with bilateral SFG. CONCLUSIONS: Our study mainly revealed altered within-DMN connectivity in cognitively unimpaired PDAR patients, which could provide further insights into the mechanism underlying cognitive decline evolution in the PD subtype. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/30321795/Resting_state_network_connectivity_in_cognitively_unimpaired_drug_naïve_patients_with_rigidity_dominant_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(18)30411-8 DB - PRIME DP - Unbound Medicine ER -