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Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds.
Molecules. 2018 Oct 14; 23(10)M

Abstract

Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced. The importance of genetic parameters on the lignan accumulation was further confirmed by gene expression analysis monitored by RT-qPCR. The corresponding antioxidant activity of these flaxseed extracts was evaluated, both in vitro, using ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and iron chelating assays, as well as in vivo, by monitoring the impact of UV-induced oxidative stress on the lipid membrane peroxidation of yeast cells. Our results, both the in vitro and in vivo studies, confirm that flaxseed extracts are an effective protector against oxidative stress. The results point out that secoisolariciresinol diglucoside, caffeic acid glucoside, and p-coumaric acid glucoside are the main contributors to the antioxidant capacity. Considering the health benefits of these compounds, the present study demonstrates that the flaxseed cultivar type could greatly influence the phytochemical intakes and, therefore, the associated biological activities. We recommend that this crucial parameter be considered in epidemiological studies dealing with flaxseeds.

Authors+Show Affiliations

Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. laurine.garros@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. laurine.garros@univ-orleans.fr. Institut de Chimie Organique et Analytique (ICOA) UMR7311, Université d'Orléans-CNRS, 45067 Orléans CEDEX 2, France. laurine.garros@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. samantha.drouet@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. samantha.drouet@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. cyrielle.corbin@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. cyrielle.corbin@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. cedric.decourtil@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. cedric.decourtil@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. thibaud.fidel@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. thibaud.fidel@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. julie.lebas-de-lacour@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. julie.lebas-de-lacour@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. emilie.leclerc@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. emilie.leclerc@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. sullivan.renouard@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. sullivan.renouard@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. duangjai.tun@mahidol.ac.th. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. duangjai.tun@mahidol.ac.th. Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayuthaya Road, Rajathevi, Bangkok 10400, Thailand. duangjai.tun@mahidol.ac.th.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. joel.doussot@lecnam.net. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. joel.doussot@lecnam.net. Le CNAM, Ecole Sciences Industrielles et Technologies de l'Information (SITI), Chimie Alimentation Santé Environnement Risque (CASER), 75141 Paris Cedex 3, France. joel.doussot@lecnam.net.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. bhabbasi@qau.edu.pk. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. bhabbasi@qau.edu.pk. Department of Biotechnology, Quaid-i-Azam University, 45320 Islamabad, Pakistan. bhabbasi@qau.edu.pk.COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. benoit.maunit@univ-orleans.fr. Institut de Chimie Organique et Analytique (ICOA) UMR7311, Université d'Orléans-CNRS, 45067 Orléans CEDEX 2, France. benoit.maunit@univ-orleans.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. eric.laine@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. eric.laine@univ-orleans.fr.Biologie des Plantes et Innovation (BIOPI) EA 3900, Université de Picardie Jules Verne, 80000 Amiens, France. ophelie.fliniaux@u-picardie.fr.Biologie des Plantes et Innovation (BIOPI) EA 3900, Université de Picardie Jules Verne, 80000 Amiens, France. francois.mesnard@u-picardie.fr.Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC) EA1207 INRA USC1328, Plant LIGNANS Team, Université d'Orléans, 28000 Chartres, France. hano@univ-orleans.fr. COSM'ACTIFS, Bioactifs et Cosmétiques, CNRS GDR3711, 45067 Orléans Cedex 2, France. hano@univ-orleans.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30322184

Citation

Garros, Laurine, et al. "Insight Into the Influence of Cultivar Type, Cultivation Year, and Site On the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum Usitatissimum L.) Seeds." Molecules (Basel, Switzerland), vol. 23, no. 10, 2018.
Garros L, Drouet S, Corbin C, et al. Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds. Molecules. 2018;23(10).
Garros, L., Drouet, S., Corbin, C., Decourtil, C., Fidel, T., Lebas de Lacour, J., Leclerc, E. A., Renouard, S., Tungmunnithum, D., Doussot, J., Abassi, B. H., Maunit, B., Lainé, É., Fliniaux, O., Mesnard, F., & Hano, C. (2018). Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds. Molecules (Basel, Switzerland), 23(10). https://doi.org/10.3390/molecules23102636
Garros L, et al. Insight Into the Influence of Cultivar Type, Cultivation Year, and Site On the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum Usitatissimum L.) Seeds. Molecules. 2018 Oct 14;23(10) PubMed PMID: 30322184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insight into the Influence of Cultivar Type, Cultivation Year, and Site on the Lignans and Related Phenolic Profiles, and the Health-Promoting Antioxidant Potential of Flax (Linum usitatissimum L.) Seeds. AU - Garros,Laurine, AU - Drouet,Samantha, AU - Corbin,Cyrielle, AU - Decourtil,Cédric, AU - Fidel,Thibaud, AU - Lebas de Lacour,Julie, AU - Leclerc,Emilie A, AU - Renouard,Sullivan, AU - Tungmunnithum,Duangjai, AU - Doussot,Joël, AU - Abassi,Bilal Haider, AU - Maunit,Benoit, AU - Lainé,Éric, AU - Fliniaux,Ophélie, AU - Mesnard,François, AU - Hano,Christophe, Y1 - 2018/10/14/ PY - 2018/09/23/received PY - 2018/10/10/revised PY - 2018/10/11/accepted PY - 2018/10/17/entrez PY - 2018/10/17/pubmed PY - 2018/12/19/medline KW - cultivar KW - environment KW - flavonol KW - flax KW - genetic KW - hydroxycinnamic acid KW - lignan KW - seed JF - Molecules (Basel, Switzerland) JO - Molecules VL - 23 IS - 10 N2 - Flaxseeds are a functional food representing, by far, the richest natural grain source of lignans, and accumulate substantial amounts of other health beneficial phenolic compounds (i.e., flavonols, hydroxycinnamic acids). This specific accumulation pattern is related to their numerous beneficial effects on human health. However, to date, little data is available concerning the relative impact of genetic and geographic parameters on the phytochemical yield and composition. Here, the major influence of the cultivar over geographic parameters on the flaxseed phytochemical accumulation yield and composition is evidenced. The importance of genetic parameters on the lignan accumulation was further confirmed by gene expression analysis monitored by RT-qPCR. The corresponding antioxidant activity of these flaxseed extracts was evaluated, both in vitro, using ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), and iron chelating assays, as well as in vivo, by monitoring the impact of UV-induced oxidative stress on the lipid membrane peroxidation of yeast cells. Our results, both the in vitro and in vivo studies, confirm that flaxseed extracts are an effective protector against oxidative stress. The results point out that secoisolariciresinol diglucoside, caffeic acid glucoside, and p-coumaric acid glucoside are the main contributors to the antioxidant capacity. Considering the health benefits of these compounds, the present study demonstrates that the flaxseed cultivar type could greatly influence the phytochemical intakes and, therefore, the associated biological activities. We recommend that this crucial parameter be considered in epidemiological studies dealing with flaxseeds. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/30322184/Insight_into_the_Influence_of_Cultivar_Type_Cultivation_Year_and_Site_on_the_Lignans_and_Related_Phenolic_Profiles_and_the_Health_Promoting_Antioxidant_Potential_of_Flax__Linum_usitatissimum_L___Seeds_ L2 - http://www.mdpi.com/resolver?pii=molecules23102636 DB - PRIME DP - Unbound Medicine ER -