Tags

Type your tag names separated by a space and hit enter

Unmeasurable small size superficial and deep foveal avascular zone in nanophthalmos: the Collaborative Nanophthalmos OCTA Study.
Br J Ophthalmol. 2019 08; 103(8):1173-1178.BJ

Abstract

AIM

To study the macular structure and vasculature in consecutive nanophthalmic eyes using optical coherence tomography angiography.

METHODS

This is a prospective, multicentre, cross-sectional study of patients with nanophthalmos (one or both eyes). The superficial and deep foveal avascular zones (FAZ) were measured both manually and with the machine's built-in automated measurement tool. Correlations between best corrected visual acuity (BCVA), central macular thickness (CMT) and subfoveolar choroidal thickness (SFCT) were calculated.

RESULTS

Sixty-five eyes of 35 subjects (16 men and 19 women) with a mean age of 37.4 years were analysed. The mean±SD of refractive error was 14.3±3.2 dioptres, axial length was 16.4±1.6 mm, CMT was 410.2±128.3 µm and SFCT was 450.1±108.3 µm. FAZ was unmeasurable small size in both the superficial and deep capillary plexus in all eyes, along with tortuosity of the superficial foveal capillaries and large vessels. Foveal folds were present in 29 eyes. Disc drusen was detected in 27 eyes and was absent in 31 eyes, while fundus autofluorescence was positive in 17 and negative in 24 eyes. BCVA varied from 20/20 to 20/800, with a mean of 20/76. Using Spearman's correlation, logarithm of the minimum angle of resolution BCVA correlated negatively with axial length (r=-0.30; p=0.015).

CONCLUSIONS

FAZ attenuation, capillary tortuosity, foveal folds and thickened subfoveal choroid characterise the nanophthalmic macula. These findings may result from a redundant retina and the absence of apoptotic foveolar retraction because of developmental arrest of the optic vesicle after closure of the embryonic fissure.

Authors+Show Affiliations

Department of Ophthalmology, American University of Beirut, Beirut, Lebanon ammansourmd@gmail.com. Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon.Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida, USA.Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.Department of Ophthalmology, Universidade Estadual de Londrina, Londrina, Brazil.Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.Vitreoretinal Service, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.Department of Ophthalmology and Visual Sciences, Federal University of Sao Paulo, Sao Paulo, Brazil.Division of Ophthalmology, Department of Visual Science, Nihon University School of Medicine, Tokyo, Japan.Division of Ophthalmology, Department of Visual Science, Nihon University School of Medicine, Tokyo, Japan.Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.Vitreoretinal Service, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.Department of Ophthalmology, Ekol Eye Hospital, Izmir, Turkey.Department of Ophthalmology, Dokuz Eylul University, School of Medicine, Izmir, Turkey.Vitreoretinal Service, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India.Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

30322954

Citation

Mansour, Ahmad M., et al. "Unmeasurable Small Size Superficial and Deep Foveal Avascular Zone in Nanophthalmos: the Collaborative Nanophthalmos OCTA Study." The British Journal of Ophthalmology, vol. 103, no. 8, 2019, pp. 1173-1178.
Mansour AM, Stewart MW, Yassine SW, et al. Unmeasurable small size superficial and deep foveal avascular zone in nanophthalmos: the Collaborative Nanophthalmos OCTA Study. Br J Ophthalmol. 2019;103(8):1173-1178.
Mansour, A. M., Stewart, M. W., Yassine, S. W., Mehanna, C. Z., Casella, A. M. B., Hamam, R. N., Chhablani, J., Lima, L. H., Shinojima, A., Kaneko, H., Younis, M. H., Shahin, H. K., Jalali, S., Kucukerdonmez, C., Saatci, A. O., Chakurkar, R., & Shields, C. L. (2019). Unmeasurable small size superficial and deep foveal avascular zone in nanophthalmos: the Collaborative Nanophthalmos OCTA Study. The British Journal of Ophthalmology, 103(8), 1173-1178. https://doi.org/10.1136/bjophthalmol-2018-312781
Mansour AM, et al. Unmeasurable Small Size Superficial and Deep Foveal Avascular Zone in Nanophthalmos: the Collaborative Nanophthalmos OCTA Study. Br J Ophthalmol. 2019;103(8):1173-1178. PubMed PMID: 30322954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unmeasurable small size superficial and deep foveal avascular zone in nanophthalmos: the Collaborative Nanophthalmos OCTA Study. AU - Mansour,Ahmad M, AU - Stewart,Michael W, AU - Yassine,Salma W, AU - Mehanna,Carl-Joe Z, AU - Casella,Antonio Marcelo B, AU - Hamam,Rola N, AU - Chhablani,Jay, AU - Lima,Luiz H, AU - Shinojima,Ari, AU - Kaneko,Hiroyuki, AU - Younis,Muhammad H, AU - Shahin,Hasan K, AU - Jalali,Subhadra, AU - Kucukerdonmez,Cem, AU - Saatci,Ali O, AU - Chakurkar,Renuka, AU - Shields,Carol L, Y1 - 2018/10/15/ PY - 2018/06/24/received PY - 2018/08/09/revised PY - 2018/10/01/accepted PY - 2018/10/17/pubmed PY - 2020/2/14/medline PY - 2018/10/17/entrez KW - angiogenesis KW - embryology and development KW - imaging KW - macula KW - sclera and episclera SP - 1173 EP - 1178 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 103 IS - 8 N2 - AIM: To study the macular structure and vasculature in consecutive nanophthalmic eyes using optical coherence tomography angiography. METHODS: This is a prospective, multicentre, cross-sectional study of patients with nanophthalmos (one or both eyes). The superficial and deep foveal avascular zones (FAZ) were measured both manually and with the machine's built-in automated measurement tool. Correlations between best corrected visual acuity (BCVA), central macular thickness (CMT) and subfoveolar choroidal thickness (SFCT) were calculated. RESULTS: Sixty-five eyes of 35 subjects (16 men and 19 women) with a mean age of 37.4 years were analysed. The mean±SD of refractive error was 14.3±3.2 dioptres, axial length was 16.4±1.6 mm, CMT was 410.2±128.3 µm and SFCT was 450.1±108.3 µm. FAZ was unmeasurable small size in both the superficial and deep capillary plexus in all eyes, along with tortuosity of the superficial foveal capillaries and large vessels. Foveal folds were present in 29 eyes. Disc drusen was detected in 27 eyes and was absent in 31 eyes, while fundus autofluorescence was positive in 17 and negative in 24 eyes. BCVA varied from 20/20 to 20/800, with a mean of 20/76. Using Spearman's correlation, logarithm of the minimum angle of resolution BCVA correlated negatively with axial length (r=-0.30; p=0.015). CONCLUSIONS: FAZ attenuation, capillary tortuosity, foveal folds and thickened subfoveal choroid characterise the nanophthalmic macula. These findings may result from a redundant retina and the absence of apoptotic foveolar retraction because of developmental arrest of the optic vesicle after closure of the embryonic fissure. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/30322954/Unmeasurable_small_size_superficial_and_deep_foveal_avascular_zone_in_nanophthalmos:_the_Collaborative_Nanophthalmos_OCTA_Study_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&pmid=30322954 DB - PRIME DP - Unbound Medicine ER -