TY - JOUR T1 - In situ reduction of silver nanoparticles by gelatin to obtain porous silver nanoparticle/chitosan composites with enhanced antimicrobial and wound-healing activity. AU - Ye,Hongli, AU - Cheng,Junwen, AU - Yu,Kun, Y1 - 2018/10/13/ PY - 2018/07/12/received PY - 2018/09/29/revised PY - 2018/10/12/accepted PY - 2018/10/17/pubmed PY - 2019/2/15/medline PY - 2018/10/17/entrez KW - Gelatin KW - Silver nanoparticle KW - Wound healing SP - 633 EP - 642 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 121 N2 - The identification of materials with beneficial properties for wound healing is a major research goal. In this study, gelatin was used as a reducing agent and stabilizer to restore silver nanoparticles (AgNPs) in situ, which were mixed with chitosan (CS), crosslinked with tannic acid, and then freeze-dried to obtain a new composite Gelatin/CS/Ag. Gelatin/CS/Ag has a dense pore structure with a pore size of about 100-250 μm. The pores were interconnected. The existence of AgNPs was proven by UV visible spectrophotometry, XRD, and electron microscopy. Gelatin/CS/Ag exhibited good mechanical properties, water absorption, and moisture retention. The material was evaluated in antibacterial experiments, and a good inhibitory effect of Gelatin/CS/Ag was observed. Gelatin/CS/Ag co-cultured with L929 cells did not show cytotoxicity. Finally, Gelatin/CS/Ag promoted wound healing and showed good biocompatibility. In summary, Gelatin/CS/Ag has promising antibacterial and wound healing properties. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/30326224/In_situ_reduction_of_silver_nanoparticles_by_gelatin_to_obtain_porous_silver_nanoparticle/chitosan_composites_with_enhanced_antimicrobial_and_wound_healing_activity_ DB - PRIME DP - Unbound Medicine ER -