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Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test.
Braz J Psychiatry. 2019 Jan-Feb; 41(1):9-14.BJ

Abstract

OBJECTIVE

Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped dose-response curves. No study, however, has investigated whether increasing doses of this drug would also cause similar curves in humans. The objective of this study was to compare the acute effects of different doses of CBD and placebo in healthy volunteers performing a simulated public speaking test (SPST), a well-tested anxiety-inducing method.

METHOD

A total of 57 healthy male subjects were allocated to receive oral CBD at doses of 150 mg (n=15), 300 mg (n=15), 600 mg (n=12) or placebo (n=15) in a double-blind procedure. During the SPST, subjective ratings on the Visual Analogue Mood Scale (VAMS) and physiological measures (systolic and diastolic blood pressure, heart rate) were obtained at six different time points.

RESULTS

Compared to placebo, pretreatment with 300 mg of CBD significantly reduced anxiety during the speech. No significant differences in VAMS scores were observed between groups receiving CBD 150 mg, 600 mg and placebo.

CONCLUSION

Our findings confirm the anxiolytic-like properties of CBD and are consonant with results of animal studies describing bell-shaped dose-response curves. Optimal therapeutic doses of CBD should be rigorously determined so that research findings can be adequately translated into clinical practice.

Authors+Show Affiliations

Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Instituto Nacional de Ciência e Tecnologia (INCT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.Instituto Nacional de Ciência e Tecnologia (INCT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.Institute for Drug Research, Faculty of Medicine, Hebrew University, Jerusalem, Israel.Instituto Nacional de Ciência e Tecnologia (INCT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil.Departamento de Neurociências e Ciências do Comportamento, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Instituto Nacional de Ciência e Tecnologia (INCT), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

30328956

Citation

Linares, Ila M., et al. "Cannabidiol Presents an Inverted U-shaped Dose-response Curve in a Simulated Public Speaking Test." Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999), vol. 41, no. 1, 2019, pp. 9-14.
Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Braz J Psychiatry. 2019;41(1):9-14.
Linares, I. M., Zuardi, A. W., Pereira, L. C., Queiroz, R. H., Mechoulam, R., Guimarães, F. S., & Crippa, J. A. (2019). Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999), 41(1), 9-14. https://doi.org/10.1590/1516-4446-2017-0015
Linares IM, et al. Cannabidiol Presents an Inverted U-shaped Dose-response Curve in a Simulated Public Speaking Test. Braz J Psychiatry. 2019 Jan-Feb;41(1):9-14. PubMed PMID: 30328956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test. AU - Linares,Ila M, AU - Zuardi,Antonio W, AU - Pereira,Luis C, AU - Queiroz,Regina H, AU - Mechoulam,Raphael, AU - Guimarães,Francisco S, AU - Crippa,José A, Y1 - 2018/10/11/ PY - 2017/02/12/received PY - 2018/01/10/accepted PY - 2018/10/18/pubmed PY - 2019/2/23/medline PY - 2018/10/18/entrez SP - 9 EP - 14 JF - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) JO - Braz J Psychiatry VL - 41 IS - 1 N2 - OBJECTIVE: Cannabidiol (CBD), one of the non-psychotomimetic compounds of Cannabis sativa, causes anxiolytic-like effects in animals, with typical bell-shaped dose-response curves. No study, however, has investigated whether increasing doses of this drug would also cause similar curves in humans. The objective of this study was to compare the acute effects of different doses of CBD and placebo in healthy volunteers performing a simulated public speaking test (SPST), a well-tested anxiety-inducing method. METHOD: A total of 57 healthy male subjects were allocated to receive oral CBD at doses of 150 mg (n=15), 300 mg (n=15), 600 mg (n=12) or placebo (n=15) in a double-blind procedure. During the SPST, subjective ratings on the Visual Analogue Mood Scale (VAMS) and physiological measures (systolic and diastolic blood pressure, heart rate) were obtained at six different time points. RESULTS: Compared to placebo, pretreatment with 300 mg of CBD significantly reduced anxiety during the speech. No significant differences in VAMS scores were observed between groups receiving CBD 150 mg, 600 mg and placebo. CONCLUSION: Our findings confirm the anxiolytic-like properties of CBD and are consonant with results of animal studies describing bell-shaped dose-response curves. Optimal therapeutic doses of CBD should be rigorously determined so that research findings can be adequately translated into clinical practice. SN - 1809-452X UR - https://www.unboundmedicine.com/medline/citation/30328956/Cannabidiol_presents_an_inverted_U_shaped_dose_response_curve_in_a_simulated_public_speaking_test_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462018005007102&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -